The 2023 MDPI Annual Report has
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15 pages, 1261 KiB  
Review
Runx2 and Polycystins in Bone Mechanotransduction: Challenges for Therapeutic Opportunities
by Antonios N. Gargalionis, Christos Adamopoulos, Christos T. Vottis, Athanasios G. Papavassiliou and Efthimia K. Basdra
Int. J. Mol. Sci. 2024, 25(10), 5291; https://doi.org/10.3390/ijms25105291 (registering DOI) - 13 May 2024
Abstract
Bone mechanotransduction is a critical process during skeletal development in embryogenesis and organogenesis. At the same time, the type and level of mechanical loading regulates bone remodeling throughout the adult life. The aberrant mechanosensing of bone cells has been implicated in the development [...] Read more.
Bone mechanotransduction is a critical process during skeletal development in embryogenesis and organogenesis. At the same time, the type and level of mechanical loading regulates bone remodeling throughout the adult life. The aberrant mechanosensing of bone cells has been implicated in the development and progression of bone loss disorders, but also in the bone-specific aspect of other clinical entities, such as the tumorigenesis of solid organs. Novel treatment options have come into sight that exploit the mechanosensitivity of osteoblasts, osteocytes, and chondrocytes to achieve efficient bone regeneration. In this regard, runt-related transcription factor 2 (Runx2) has emerged as a chief skeletal-specific molecule of differentiation, which is prominent to induction by mechanical stimuli. Polycystins represent a family of mechanosensitive proteins that interact with Runx2 in mechano-induced signaling cascades and foster the regulation of alternative effectors of mechanotransuction. In the present narrative review, we employed a PubMed search to extract the literature concerning Runx2, polycystins, and their association from 2000 to March 2024. The keywords stated below were used for the article search. We discuss recent advances regarding the implication of Runx2 and polycystins in bone remodeling and regeneration and elaborate on the targeting strategies that may potentially be applied for the treatment of patients with bone loss diseases. Full article
(This article belongs to the Special Issue Cells and Molecules in Bone Remodeling and Repair)
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18 pages, 2740 KiB  
Entry
Displacement Micropump with Check Valves for Diabetes Care—The Challenge of Pumping Insulin at Negative Pressure
by Eric Chappel
Encyclopedia 2024, 4(2), 818-835; https://doi.org/10.3390/encyclopedia4020052 (registering DOI) - 13 May 2024
Definition
The displacement micropump with passive check valves is an attractive solution for precise insulin infusion in patients with type I diabetes. Unlike most insulin pumps that push insulin from a cartridge using a piston, a displacement micropump will first pull insulin from the [...] Read more.
The displacement micropump with passive check valves is an attractive solution for precise insulin infusion in patients with type I diabetes. Unlike most insulin pumps that push insulin from a cartridge using a piston, a displacement micropump will first pull insulin from the reservoir before infusing it into the patient. This dual sequence introduces new challenges in terms of insulin stability, notably if the reservoir is not pressurized. After an introduction to displacement micropumps and a brief review of the insulin degradation mechanism, micropump design rules are discussed in light of microfluidic theory. Full article
(This article belongs to the Section Medicine & Pharmacology)
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9 pages, 646 KiB  
Communication
Sleep Quality and Interoception Are Associated with Generalized Anxiety in Baccalaureate Nursing Students: A Cross-Sectional Study
by Laura A. Robinson, Pamela R. Short and Andrew D. Frugé
Nurs. Rep. 2024, 14(2), 1184-1192; https://doi.org/10.3390/nursrep14020090 (registering DOI) - 13 May 2024
Abstract
Baccalaureate nursing students are at increased risk for anxiety and related mood disorders. We conducted a cross-sectional study to explore the relationships among anxiety symptoms measured by the Generalized Anxiety Disorder (GAD-7) questionnaire and lifestyle behaviors including habitual diet, sleep quality (Pittsburg Sleep [...] Read more.
Baccalaureate nursing students are at increased risk for anxiety and related mood disorders. We conducted a cross-sectional study to explore the relationships among anxiety symptoms measured by the Generalized Anxiety Disorder (GAD-7) questionnaire and lifestyle behaviors including habitual diet, sleep quality (Pittsburg Sleep Quality Index [PSQI]), and physical activity. Descriptive statistics were obtained for sample characteristics, and Pearson correlations and backward stepwise linear regression explored relationships between the GAD-7 scores, the Multidimensional Assessment of Interoceptive Awareness, version 2 (MAIA-2) subscales, and other variables. Sixty-eight students completed the survey, with 38% having moderate-to-severe anxiety. On average, respondents had moderate diet quality (Healthy Eating Index median 60/100 [range 51–75]), had high sleep quality (PSQI median 7/21 [range 4–10]), and were highly active, with a median of 43 (range 24–78) weekly metabolic equivalent (MET) hours. Sixty-seven out of 68 respondents indicated a willingness to change lifestyle behaviors; the most prevalent time-related factors were school and social commitments, with stress and financial constraints being reported among half or more of respondents. Regression analysis determined that PSQI (β = 0.446) and the MAIA-2 Not-Worrying subscale (β = −0.366) were significant (p < 0.001 for both) predictors of anxiety severity. These results indicate that mindfulness and sleep hygiene may be the most actionable foci for interventions to reduce anxiety in baccalaureate nursing students. This study was not registered as a clinical trial. Full article
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14 pages, 1161 KiB  
Article
Variation in Root Biomass and Distribution Based on the Topography, Soil Properties, and Tree Influence Index: The Case of Mt. Duryun in Republic of Korea
by Julia Inacio Carvalho, Mark Bryan Carayugan, Lan Thi Ngoc Tran, Jonathan O. Hernandez, Woo Bin Youn, Ji Young An and Byung Bae Park
Plants 2024, 13(10), 1340; https://doi.org/10.3390/plants13101340 (registering DOI) - 13 May 2024
Abstract
Root biomass and distribution are influenced by abiotic factors, such as topography and soil physicochemical properties, determining belowground productivity. Hence, we investigated the variation in root biomass and vertical root distribution based on the topography, soil physicochemical properties, and tree influence index, and [...] Read more.
Root biomass and distribution are influenced by abiotic factors, such as topography and soil physicochemical properties, determining belowground productivity. Hence, we investigated the variation in root biomass and vertical root distribution based on the topography, soil physicochemical properties, and tree influence index, and their relationships, across soil depths (0–10 cm, 10–20 cm, and 20–30 cm) and topographical gradients in a warm-temperate forest in Mt. Duryun, Republic of Korea. Two contrasting research sites were established: a lower slope oriented at ≤3° and an upper slope with a slope of 30°. Each site comprised eleven 400 m2 sampling plots from which root samples from various diameter classes (<2 mm, 2–5 mm, 5–10 mm, and >10 mm) were collected. While the bulk density increased with soil depth in the lower slope, the organic matter, available phosphorus, Ca2+, and Mg2+ showed a reversed pattern. Linear mixed-effects models generally revealed significant negative correlations between root biomass and soil pH, total nitrogen, and cation exchange capacity, particularly in small roots (βstd = −1.03 to −1.51) and coarse roots (βstd = −6.30). Root biomass exhibited a 10–15% increase in the upper slope compared to the lower slope, particularly in fine (median = 52.0 g m2–65.64 g m2) and medium roots (median = 56.04 g m2–69.52 g m2) at a 0–20 cm soil depth. While no significant correlation between root biomass and the tree influence index was found on the lower slope, a different pattern was found on the upper slope. Our results indicate that the variation in root biomass and distribution can also be explained by the differences in the soil environment and topographical positions. Full article
(This article belongs to the Section Plant Ecology)
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10 pages, 3703 KiB  
Article
Boil-Off Gas Generation in Vacuum-Jacketed Valve Used in Liquid Hydrogen Storage Tank
by Hae-Seong Hwang, Seong-Un Woo and Seung-Ho Han
Energies 2024, 17(10), 2341; https://doi.org/10.3390/en17102341 (registering DOI) - 13 May 2024
Abstract
The boiling point of liquid hydrogen is very low, at −253 °C under atmospheric pressure, which causes boil-off gas (BOG) to occur during storage and transport due to heat penetration. Because the BOG must be removed through processes such as re-liquefaction, venting to [...] Read more.
The boiling point of liquid hydrogen is very low, at −253 °C under atmospheric pressure, which causes boil-off gas (BOG) to occur during storage and transport due to heat penetration. Because the BOG must be removed through processes such as re-liquefaction, venting to the atmosphere, or incineration, related studies are required to estimate the heat transfer of storage and transport devices and to improve insulation to reduce BOG generation. In this study, a vaporization analysis was performed on a vacuum-jacketed valve used in liquid hydrogen storage and transport devices to calculate the amount of BOG generation considering the flow characteristics at the vena contracta and the saturation temperature. At a pressure of 1 bar in the liquid hydrogen storage tank, the maximum fluid flow velocity and minimum static pressure occurred at the vena contracta, with values of 62.9 m/s and −0.4 bar, respectively, and the BOG generation rate was estimated as 0.132 m3/h, where the saturation temperature was minimized at 19.3 K. Furthermore, through case studies, when the pressure in the liquid hydrogen storage tank increased to 1.5 and 2 bar, the static pressure and saturation temperature decreased, and the BOG generation rate increased to 0.221 and 0.283 m3/h, respectively. Full article
(This article belongs to the Topic Advanced Heat and Mass Transfer Technologies)
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15 pages, 2552 KiB  
Article
Evaluation of PD-L1 Expression in Colorectal Carcinomas by Comparing Scoring Methods and Their Significance in Relation to Clinicopathologic Parameters
by Mirela Frančina, Mislav Mikuš, Marin Mamić, Tihomir Jovanović, Mario Ćorić, Božica Lovrić, Ivan Vukoja, Goran Zukanović, Kristijan Matković, Jasmina Rajc, Ferdinand Slišurić, Mateja Jurić-Marelja, Goran Augustin and Ilijan Tomaš
Diagnostics 2024, 14(10), 1007; https://doi.org/10.3390/diagnostics14101007 (registering DOI) - 13 May 2024
Abstract
Background: This study aims to evaluate PD-L1 expression in colorectal carcinomas (CRCs) by using the tumor proportion score (TPS) and the combined positive score (CPS), and to investigate whether there is a correlation with clinicopathologic features. Methods: A cross-sectional study was conducted that [...] Read more.
Background: This study aims to evaluate PD-L1 expression in colorectal carcinomas (CRCs) by using the tumor proportion score (TPS) and the combined positive score (CPS), and to investigate whether there is a correlation with clinicopathologic features. Methods: A cross-sectional study was conducted that included samples from patients with colorectal adenocarcinoma treated with colon resection and rectal resection after neoadjuvant radio- and chemotherapy at the Department of Abdominal Surgery at Požega Hospital in the period from 2017 to 2022. The study included 102 tumor tissue samples from patients after resection and the pathohistological diagnosis of adenocarcinoma. Results: In our study, the PD-L1 positivity rate after the TPS was 42 (41%) samples, and after the CPS, 97 (95%) of them (p < 0.001). The positive expression of PD-L1 in tumor cells using the TPS method showed a statistically significant association with adenocarcinoma (TPS ≥ 10–50% and ≥50%). There were significantly more that were moderately differentiated, with TPS ≥ 50%, and those poorly differentiated had values ≥ 10–50%. There were significantly more patients with a status of more than one positive lymph node with TPS values ≥ 10–50%. Patients without metastases in the lymph nodes are significantly more likely to have CPS values > 50%, compared with other lymph node statuses. Conclusions: These results suggest that the total number of PD-L1-expressing cells, including tumor and immune cells, is a more sensitive biomarker than the number of PD-L1-expressing tumor cells alone in CRC. Full article
(This article belongs to the Section Pathology and Molecular Diagnostics)
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20 pages, 16723 KiB  
Article
The Antioxidant Dendrobium officinale Polysaccharide Modulates Host Metabolism and Gut Microbiota to Alleviate High-Fat Diet-Induced Atherosclerosis in ApoE−/− Mice
by Jingyi Qi, Shuaishuai Zhou, Guisheng Wang, Rongrong Hua, Xiaoping Wang, Jian He, Zi Wang, Yinhua Zhu, Junjie Luo, Wenbiao Shi, Yongting Luo and Xiaoxia Chen
Antioxidants 2024, 13(5), 599; https://doi.org/10.3390/antiox13050599 (registering DOI) - 13 May 2024
Abstract
Background: The discovery of traditional plants’ medicinal and nutritional properties has opened up new avenues for developing pharmaceutical and dietary strategies to prevent atherosclerosis. However, the effect of the antioxidant Dendrobium officinale polysaccharide (DOP) on atherosclerosis is still not elucidated. Purpose: This study [...] Read more.
Background: The discovery of traditional plants’ medicinal and nutritional properties has opened up new avenues for developing pharmaceutical and dietary strategies to prevent atherosclerosis. However, the effect of the antioxidant Dendrobium officinale polysaccharide (DOP) on atherosclerosis is still not elucidated. Purpose: This study aims to investigate the inhibitory effect and the potential mechanism of DOP on high-fat diet-induced atherosclerosis in Apolipoprotein E knockout (ApoE−/−) mice. Study design and methods: The identification of DOP was measured by high-performance gel permeation chromatography (HPLC) and Fourier transform infrared spectroscopy (FTIR). We used high-fat diet (HFD)-induced atherosclerosis in ApoE−/− mice as an animal model. In the DOP intervention stage, the DOP group was treated by gavage with 200 μL of 200 mg/kg DOP at regular times each day and continued for eight weeks. We detected changes in serum lipid profiles, inflammatory factors, anti-inflammatory factors, and antioxidant capacity to investigate the effect of the DOP on host metabolism. We also determined microbial composition using 16S rRNA gene sequencing to investigate whether the DOP could improve the structure of the gut microbiota in atherosclerotic mice. Results: DOP effectively inhibited histopathological deterioration in atherosclerotic mice and significantly reduced serum lipid levels, inflammatory factors, and malondialdehyde (F/B) production. Additionally, the levels of anti-inflammatory factors and the activity of antioxidant enzymes, including superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX), were significantly increased after DOP intervention. Furthermore, we found that DOP restructures the gut microbiota composition by decreasing the Firmicutes/Bacteroidota (F/B) ratio. The Spearman’s correlation analysis indicated that serum lipid profiles, antioxidant activity, and pro-/anti-inflammatory factors were associated with Firmicutes, Bacteroidota, Allobaculum, and Coriobacteriaceae_UCG-002. Conclusions: This study suggests that DOP has the potential to be developed as a food prebiotic for the treatment of atherosclerosis in the future. Full article
(This article belongs to the Special Issue Antioxidants in Cardiovascular Diseases)
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24 pages, 7433 KiB  
Article
Improved YOLOv8 and SAHI Model for the Collaborative Detection of Small Targets at the Micro Scale: A Case Study of Pest Detection in Tea
by Rong Ye, Quan Gao, Ye Qian, Jihong Sun and Tong Li
Agronomy 2024, 14(5), 1034; https://doi.org/10.3390/agronomy14051034 (registering DOI) - 13 May 2024
Abstract
Pest target identification in agricultural production environments is challenging due to the dense distribution, small size, and high density of pests. Additionally, changeable environmental lighting and complex backgrounds further complicate the detection process. This study focuses on enhancing the recognition performance of tea [...] Read more.
Pest target identification in agricultural production environments is challenging due to the dense distribution, small size, and high density of pests. Additionally, changeable environmental lighting and complex backgrounds further complicate the detection process. This study focuses on enhancing the recognition performance of tea pests by introducing a lightweight pest image recognition model based on the improved YOLOv8 architecture. First, slicing-aided fine-tuning and slicing-aided hyper inference (SAHI) are proposed to partition input images for enhanced model performance on low-resolution images and small-target detection. Then, based on an ELAN, a generalized efficient layer aggregation network (GELAN) is designed to replace the C2f module in the backbone network, enhance its feature extraction ability, and construct a lightweight model. Additionally, the MS structure is integrated into the neck network of YOLOv8 for feature fusion, enhancing the extraction of fine-grained and coarse-grained semantic information. Furthermore, the BiFormer attention mechanism, based on the Transformer architecture, is introduced to amplify target characteristics of tea pests. Finally, the inner-MPDIoU, based on auxiliary borders, is utilized as a replacement for the original loss function to enhance its learning capacity for complex pest samples. Our experimental results demonstrate that the enhanced YOLOv8 model achieves a precision of 96.32% and a recall of 97.95%, surpassing those of the original YOLOv8 model. Moreover, it attains an mAP@50 score of 98.17%. Compared to Faster R-CNN, SSD, YOLOv5, YOLOv7, and YOLOv8, its average accuracy is 17.04, 11.23, 5.78, 3.75, and 2.71 percentage points higher, respectively. The overall performance of YOLOv8 outperforms that of current mainstream detection models, with a detection speed of 95 FPS. This model effectively balances lightweight design with high accuracy and speed in detecting small targets such as tea pests. It can serve as a valuable reference for the identification and classification of various insect pests in tea gardens within complex production environments, effectively addressing practical application needs and offering guidance for the future monitoring and scientific control of tea insect pests. Full article
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15 pages, 1052 KiB  
Article
Can Environmental Information Disclosure Improve Energy Efficiency in Manufacturing? Evidence from Chinese Enterprises
by Linfang Tan, Da Gao and Xiaowei Liu
Energies 2024, 17(10), 2342; https://doi.org/10.3390/en17102342 (registering DOI) - 13 May 2024
Abstract
Improving the energy efficiency of enterprises is one of the key means to solve the problem of energy shortage. It is of great significance to investigate how environmental information disclosure (EDI) promotes the green total factor energy efficiency (GTFEE) of enterprises. Based on [...] Read more.
Improving the energy efficiency of enterprises is one of the key means to solve the problem of energy shortage. It is of great significance to investigate how environmental information disclosure (EDI) promotes the green total factor energy efficiency (GTFEE) of enterprises. Based on this, this study calculates the GTFEE of enterprises by combining the database of Chinese manufacturing and the pollutant emission of industrial enterprises and investigates the impact of EDI on the GTFEE of manufacturing industries by using a difference-in-difference model. The following is found: (1) EDI can significantly promote the manufacturing enterprises’ GTFEE, and the results are still valid after a series of robustness tests; (2) Mechanism analysis shows that EDI can improve the GTFEE of manufacturing enterprises by promoting technological innovation and optimizing energy structure; (3) The heterogeneity analysis shows that EID is more positive on firms’ GTFEE in the eastern than western regions. The positive impact is greater for non-state-owned, low-energy consumption, export, and polluting enterprises. The findings of this paper provide a theoretical basis and practical enlightenment for the government to promote the green development transformation of enterprises. Full article
(This article belongs to the Collection Energy Transition towards Carbon Neutrality)
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10 pages, 3219 KiB  
Article
Evaluation of Phototoxicity of Short-Wavelength Laser Light Utilizing PCNA Accumulation
by Tetsuya Matsuyama, Noboru Osaka, Mikiya Yamaguchi, Naohiro Kanamaru, Kenji Wada, Ai Kawakita, Kaori Murata, Kenji Sugimoto and Koichi Okamoto
Micromachines 2024, 15(5), 646; https://doi.org/10.3390/mi15050646 (registering DOI) - 13 May 2024
Abstract
In recent years, diseases such as age-related macular degeneration and retinal pigment degeneration caused by excessive exposure to short-wavelength visible light have become significant concerns. With the aim of quantitatively evaluating the toxicity of short-wavelength light, proliferating cell nuclear antigen (PCNA) accumulation at [...] Read more.
In recent years, diseases such as age-related macular degeneration and retinal pigment degeneration caused by excessive exposure to short-wavelength visible light have become significant concerns. With the aim of quantitatively evaluating the toxicity of short-wavelength light, proliferating cell nuclear antigen (PCNA) accumulation at the irradiation site was investigated using live cell imaging techniques to irradiate individual living cells with short-wavelength laser light. By examining the dependency of PCNA accumulation on the irradiation site within the cells and their cell cycle, it was observed that PCNA accumulation occurred only when the cell nucleus of cells in the S phase of the cell cycle was irradiated. We investigated the accumulation of PCNA at the laser irradiation site using laser light at wavelengths of 405 nm and 375 nm, with intensities ranging from 0.5 μW to 9.0 μW. The results confirmed an increase in PCNA accumulation with increasing intensity, and a higher accumulation was observed with laser light irradiation at a wavelength of 375 nm compared to 405 nm. By comparing the PCNA accumulation and 24 h cell viability, we demonstrated the feasibility of quantitatively assessing laser light toxicity through the measurement of PCNA accumulation. Full article
(This article belongs to the Special Issue Ultraviolet Devices and Ultraviolet Germicidal Irradiation)
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14 pages, 3423 KiB  
Article
Plant Density and Health Evaluation in Green Stormwater Infrastructure Using Unmanned-Aerial-Vehicle-Based Imagery
by Jingwen Xue, Xuejun Qian, Dong Hee Kang and James G. Hunter
Appl. Sci. 2024, 14(10), 4118; https://doi.org/10.3390/app14104118 (registering DOI) - 13 May 2024
Abstract
Over the past few decades, there has been a notable surge in interest in green stormwater infrastructure (GSI). This trend is a result of the need to effectively address issues related to runoff, pollution, and the adverse effects of urbanization and impervious surfaces [...] Read more.
Over the past few decades, there has been a notable surge in interest in green stormwater infrastructure (GSI). This trend is a result of the need to effectively address issues related to runoff, pollution, and the adverse effects of urbanization and impervious surfaces on waterways. Concurrently, umanned aerial vehicles (UAVs) have gained prominence across applications, including photogrammetry, military applications, precision farming, agricultural land, forestry, environmental surveillance, remote-sensing, and infrastructure maintenance. Despite the widespread use of GSI and UAV technologies, there remains a glaring gap in research focused on the evaluation and maintenance of the GSIs using UAV-based imagery. This study aimed to develop an integrated framework to evaluate plant density and health within GSIs using UAV-based imagery. This integrated framework incorporated the UAV (commonly known as a drone), WebOpenDroneMap (WebDOM), ArcMap, PyCharm, and the Canopeo application. The UAV-based images of GSI components, encompassing trees, grass, soil, and unhealthy trees, as well as entire GSIs (e.g., bioretention and green roofs) within the Morgan State University (MSU) campus were collected, processed, and analyzed using this integrated framework. Results indicated that the framework yielded highly accurate predictions of plant density with a high R2 value of 95.8% and lower estimation errors of between 3.9% and 9.7%. Plant density was observed to vary between 63.63% and 75.30% in the GSIs at the MSU campus, potentially attributable to the different types of GSI, varying facility ages, and inadequate maintenance. Normalized difference vegetation index (NDVI) maps and scales of two GSIs were also generated to evaluate plant health. The NDVI and plant density results can be used to suggest where new plants can be added and to provide proper maintenance to achieve proper functions within the GSIs. This study provides a framework for evaluating plant performance within the GSIs using the collected UAV-based imagery. Full article
(This article belongs to the Section Environmental Sciences)
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29 pages, 2322 KiB  
Review
A Consolidated Understanding of the Contribution of Redox Dysregulation in the Development of Hearing Impairment
by Xin Yi Yeo, Soohyun Kwon, Kimberley R. Rinai, Sungsu Lee, Sangyong Jung and Raekil Park
Antioxidants 2024, 13(5), 598; https://doi.org/10.3390/antiox13050598 (registering DOI) - 13 May 2024
Abstract
The etiology of hearing impairment is multifactorial, with contributions from both genetic and environmental factors. Although genetic studies have yielded valuable insights into the development and function of the auditory system, the contribution of gene products and their interaction with alternate environmental factors [...] Read more.
The etiology of hearing impairment is multifactorial, with contributions from both genetic and environmental factors. Although genetic studies have yielded valuable insights into the development and function of the auditory system, the contribution of gene products and their interaction with alternate environmental factors for the maintenance and development of auditory function requires further elaboration. In this review, we provide an overview of the current knowledge on the role of redox dysregulation as the converging factor between genetic and environmental factor-dependent development of hearing loss, with a focus on understanding the interaction of oxidative stress with the physical components of the peripheral auditory system in auditory disfunction. The potential involvement of molecular factors linked to auditory function in driving redox imbalance is an important promoter of the development of hearing loss over time. Full article
(This article belongs to the Special Issue Oxidative Stress in Ear Damage)
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8 pages, 528 KiB  
Article
Surgical Outcomes of da Vinci Xi™ and da Vinci SP™ for Early-Stage Endometrial Cancer in Patients Undergoing Hysterectomy
by Motoki Matsuura, Sachiko Nagao, Shoko Kurokawa, Masato Tamate, Taishi Akimoto and Tsuyoshi Saito
J. Clin. Med. 2024, 13(10), 2864; https://doi.org/10.3390/jcm13102864 (registering DOI) - 13 May 2024
Abstract
Objectives: This study aimed to evaluate and compare the feasibility and outcomes of two robotic hysterectomy (da Vinci Xi™ vs. da Vinci SP™) systems without lymph node dissection in patients with early-stage endometrial cancer, and assess the postoperative recurrence rate and overall [...] Read more.
Objectives: This study aimed to evaluate and compare the feasibility and outcomes of two robotic hysterectomy (da Vinci Xi™ vs. da Vinci SP™) systems without lymph node dissection in patients with early-stage endometrial cancer, and assess the postoperative recurrence rate and overall survival of patients. Methods: A retrospective review of 84 patients who underwent robotic hysterectomy for endometrial cancer (stage 1A) was conducted. Surgical procedures, patient characteristics, intraoperative measures, and postoperative outcomes were statistically analyzed. A single gynecologist performed all surgeries. Results: Patient characteristics, average age, and body mass index showed no significant differences between the two models. The total operative time was significantly shorter with da Vinci SP™. Recurrence was identified in only one patient operated on with da Vinci Xi™. All patients were alive during analysis, with a median overall survival of 38 and 9 months for da Vinci Xi™ and da Vinci SP™, respectively. Conclusions: Robotic hysterectomy without lymph node dissection appears to be a safe and effective approach for patients with early-stage endometrial cancer. The da Vinci SP offers the advantage of shorter operative times than the da Vinci Xi™. These findings support the consideration of robotic surgery as a viable option for selected patients. Full article
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26 pages, 1218 KiB  
Article
Impact of the Local Dynamics on Exit Choice Behaviour in Evacuation Model
by Sensen Xing, Cheng Wang, Dongli Gao, Wei Wang, Anthony Chun Yin Yuen, Eric Wai Ming Lee, Guan Heng Yeoh and Qing Nian Chan
Fire 2024, 7(5), 167; https://doi.org/10.3390/fire7050167 (registering DOI) - 13 May 2024
Abstract
This study investigated the interplay between exit selection models and local pedestrian movement patterns within floor field frameworks. Specifically, this investigation analysed the performance of a multinomial logit exit choice model, incorporating both expected utility theory and cumulative prospect theory frameworks when coupled [...] Read more.
This study investigated the interplay between exit selection models and local pedestrian movement patterns within floor field frameworks. Specifically, this investigation analysed the performance of a multinomial logit exit choice model, incorporating both expected utility theory and cumulative prospect theory frameworks when coupled with three distinct local-level pedestrian movement models (FF-Von Neumann, FF-Moore, and NSFF). The expected utility theory framework considers the deterministic component as a linear relationship, while the cumulative prospect theory framework further considers the decision-maker’s risky attitudes by transforming objective terms into subjective terms using a power value function. The core objective was to comprehend how local movement dynamics, as represented by the floor field models, influence decision-making during exit selection. Comparative analyses revealed intriguing variations between the three local models, despite their shared expected utility theory-based exit choice framework. These discrepancies stemmed from the diverse pedestrian trajectory behaviours generated by each model. Consequently, these local dynamics impacted the decision-maker’s assessment of critical factors, such as the number of evacuees close to the decision-maker (NCDM) and the number of evacuees close to an exit (NCE), which the exit choice model incorporates. These assessments, in turn, significantly affected higher-level decision-making. The integration of the three models with the multinomial logit exit choice model, using either cumulative prospect theory and expected utility theory frameworks, further strengthened the observed bilateral relationship. While the specific nature of this relationship varied depending on the chosen framework and its implementation details, these consistent findings demonstrate the robustness of the results. This reinforced the influence of local-level pedestrian dynamics on higher-level exit selection, highlighting the importance of accurate crowd dynamics modelling, especially when advanced exit choice models consider local movement factors. Full article
(This article belongs to the Special Issue Ensuring Safety against Fires in Overcrowded Urban Areas)
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14 pages, 1763 KiB  
Article
Characterisation of Low Molecular Weight Compounds of Strawberry Tree (Arbutus unedo L.) Fruit Spirit Aged with Oak Wood
by Ofélia Anjos, Carlos A. L. Antunes, Sheila Oliveira-Alves, Sara Canas and Ilda Caldeira
Fermentation 2024, 10(5), 253; https://doi.org/10.3390/fermentation10050253 (registering DOI) - 13 May 2024
Abstract
There is a trend towards the commercialisation of strawberry tree fruit spirit (AUS) with wood ageing, motivated by its favourable sensory characteristics. Additionally, further studies are necessary to elucidate the optimal conditions regarding ageing time and toasting level. This study evaluated the changes [...] Read more.
There is a trend towards the commercialisation of strawberry tree fruit spirit (AUS) with wood ageing, motivated by its favourable sensory characteristics. Additionally, further studies are necessary to elucidate the optimal conditions regarding ageing time and toasting level. This study evaluated the changes in colour and low molecular weight compounds (LMWC) of AUS aged for three and six months using oak wood (Quercus robur L.) with light, medium and medium plus toasting levels. For this purpose, phenolic acids (gallic, ellagic, ferulic and syringic acids), phenolic aldehydes (vanillin, syringaldehyde, coniferaldehyde and sinapaldehyde) and furanic aldehydes (furfural, 5-hydroxymethylfurfural and 5-methylfurfural) were quantified using the HPLC method. Chromatic characteristics, colour sensory analysis and total polyphenol index were also analysed. Fourier transform near-infrared spectroscopy (FT-NIR) was used to discriminate between samples. The results emphasized the favourable effect of oak wood contact on enhancing the colour and enriching AUS with low molecular weight compounds (LMWC). AUS aged in medium toasted wood exhibits high levels of total phenolic index, 5-hydroxymethylfurfural, furfural, coniferaldehyde, sinapaldehyde, sum LMWC and chromatic characteristics b* and C. Concentrations of syringaldehyde, ellagic acid, vanillin and syringic acid and a lighter colour (a* chromaticity coordinates) are higher in AUS aged with slightly more toasted wood. Nearly all analysed parameters showed an increase with ageing time. The FT-NIR technique allowed for the differentiation of aged AUS, focusing more on ageing time than on toasting level. Full article
(This article belongs to the Special Issue Fermentation: 10th Anniversary)
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11 pages, 2484 KiB  
Article
In Vivo Classification and Characterization of Carotid Atherosclerotic Lesions with Integrated 18F-FDG PET/MRI
by Fan Yu, Yue Zhang, Heyu Sun, Xiaoran Li, Yi Shan, Chong Zheng, Bixiao Cui, Jing Li, Yang Yang, Bin Yang, Yan Ma, Yabing Wang, Liqun Jiao, Xiang Li and Jie Lu
Diagnostics 2024, 14(10), 1006; https://doi.org/10.3390/diagnostics14101006 (registering DOI) - 13 May 2024
Abstract
Background: The aim of this study was to exploit integrated PET/MRI to simultaneously evaluate the morphological, component, and metabolic features of advanced atherosclerotic plaques and explore their incremental value. Methods: In this observational prospective cohort study, patients with advanced plaque in the carotid [...] Read more.
Background: The aim of this study was to exploit integrated PET/MRI to simultaneously evaluate the morphological, component, and metabolic features of advanced atherosclerotic plaques and explore their incremental value. Methods: In this observational prospective cohort study, patients with advanced plaque in the carotid artery underwent 18F-FDG PET/MRI. Plaque morphological features were measured, and plaque component features were determined via MRI according to AHA lesion-types. Maximum standardized uptake values (SUVmax) and tissue to background ratio (TBR) on PET were calculated. Area under the receiver-operating characteristic curve (AUC) and net reclassification improvement (NRI) were used to compare the incremental contribution of FDG uptake when added to AHA lesion-types for symptomatic plaque classification. Results: A total of 280 patients with advanced plaque in the carotid artery were recruited. A total of 402 plaques were confirmed, and 87 of 402 (21.6%) were symptomatic plaques. 18F-FDG PET/MRI was performed a mean of 38 days (range 1–90) after the symptom. Increased stenosis degree (61.5% vs. 50.0%, p < 0.001) and TBR (2.96 vs. 2.32, p < 0.001) were observed in symptomatic plaques compared with asymptomatic plaques. The performance of the combined model (AHA lesion type VI + stenosis degree + TBR) for predicting symptomatic plaques was the best among all models (AUC = 0.789). The improvement of the combined model (AHA lesion type VII + stenosis degree + TBR) over AHA lesion type VII model for predicting symptomatic plaques was the highest (AUC = 0.757/0.454, combined model/AHA lesion type VII model), and the NRI was 50.7%. Conclusions: Integrated PET/MRI could simultaneously evaluate the morphological component and inflammation features of advanced atherosclerotic plaques and provide supplementary optimization information over AHA lesion-types for identifying vulnerable plaques in atherosclerosis subjects to achieve further stratification of stroke risk. Full article
(This article belongs to the Special Issue Recent Advances in Radiomics in Medical Imaging)
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23 pages, 411 KiB  
Review
Advancements in the Management of Postoperative Air Leak following Thoracic Surgery: From Traditional Practices to Innovative Therapies
by Vasileios Leivaditis, Konstantinos Skevis, Francesk Mulita, Christos Tsalikidis, Athanasia Mitsala, Manfred Dahm, Konstantinos Grapatsas, Athanasios Papatriantafyllou, Konstantinos Markakis, Emmanuel Kefaloyannis, Glykeria Christou, Michail Pitiakoudis and Efstratios Koletsis
Medicina 2024, 60(5), 802; https://doi.org/10.3390/medicina60050802 (registering DOI) - 13 May 2024
Abstract
Background: Postoperative air leak (PAL) is a frequent and potentially serious complication following thoracic surgery, characterized by the persistent escape of air from the lung into the pleural space. It is associated with extended hospitalizations, increased morbidity, and elevated healthcare costs. Understanding the [...] Read more.
Background: Postoperative air leak (PAL) is a frequent and potentially serious complication following thoracic surgery, characterized by the persistent escape of air from the lung into the pleural space. It is associated with extended hospitalizations, increased morbidity, and elevated healthcare costs. Understanding the mechanisms, risk factors, and effective management strategies for PAL is crucial in improving surgical outcomes. Aim: This review seeks to synthesize all known data concerning PAL, including its etiology, risk factors, diagnostic approaches, and the range of available treatments from conservative measures to surgical interventions, with a special focus on the use of autologous plasma. Materials and Methods: A comprehensive literature search of databases such as PubMed, Cochrane Library, and Google Scholar was conducted for studies and reviews published on PAL following thoracic surgery. The selection criteria aimed to include articles that provided insights into the incidence, mechanisms, risk assessment, diagnostic methods, and treatment options for PAL. Special attention was given to studies detailing the use of autologous plasma in managing this complication. Results: PAL is influenced by a variety of patient-related, surgical, and perioperative factors. Diagnosis primarily relies on clinical observation and imaging, with severity assessments guiding management decisions. Conservative treatments, including chest tube management and physiotherapy, serve as the initial approach, while persistent leaks may necessitate surgical intervention. Autologous plasma has emerged as a promising treatment, offering a novel mechanism for enhancing pleural healing and reducing air leak duration, although evidence is still evolving. Conclusions: Effective management of PAL requires a multifaceted approach tailored to the individual patient’s needs and the specifics of their condition. Beyond the traditional treatment approaches, innovative treatment modalities offer the potential to improve outcomes for patients experiencing PAL after thoracic surgery. Further research is needed to optimize treatment protocols and integrate new therapies into clinical practice. Full article
(This article belongs to the Section Surgery)
28 pages, 1782 KiB  
Article
Searching for a Cheap Robust Steering Controller
by Trevor Vidano and Francis Assadian
Electronics 2024, 13(10), 1908; https://doi.org/10.3390/electronics13101908 (registering DOI) - 13 May 2024
Abstract
The study of lateral steering control for Automated Driving Systems identifies new control solutions more often than new control problems. This is likely due to the maturity of the field. To prevent repeating efforts toward solving already-solved problems, what is needed is a [...] Read more.
The study of lateral steering control for Automated Driving Systems identifies new control solutions more often than new control problems. This is likely due to the maturity of the field. To prevent repeating efforts toward solving already-solved problems, what is needed is a cohesive way of evaluating all developed controllers under a wide variety of environmental conditions. This work serves as a step in this direction. Four controllers are tested on five maneuvers representing highways and collision avoidance trajectories. Each controller and maneuver combination is repeated on five sets of environmental conditions or Operational Design Domains (ODDs). The design of these ODDs ensures the translation of these experimental results to real-world applications. The commercial software, CarSim 2020, is extended with Simulink models of the environment, sensor dynamics, and state estimation performances to perform highly repeatable and realistic evaluations of each controller. The results of this work demonstrate that most of the combinations of maneuvers and ODDs have existing cheap controllers that achieve satisfactorily safe performance. Therefore, this field’s research efforts should be directed toward finding new control problems in lateral path tracking rather than proposing new controllers for ODDs that are already solved. Full article
(This article belongs to the Special Issue Autonomous and Connected Vehicles)
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20 pages, 21398 KiB  
Article
Leveraging Transfer Learning and U-Nets Method for Improved Gap Filling in Himawari Sea Surface Temperature Data Adjacent to Taiwan
by Dimas Pradana Putra and Po-Chun Hsu
ISPRS Int. J. Geo-Inf. 2024, 13(5), 162; https://doi.org/10.3390/ijgi13050162 (registering DOI) - 13 May 2024
Abstract
Satellite sea surface temperature (SST) images are valuable for various oceanic applications, including climate monitoring, ocean modeling, and marine ecology. However, cloud cover often obscures SST signals, creating gaps in the data that reduce resolution and hinder spatiotemporal analysis, particularly in the waters [...] Read more.
Satellite sea surface temperature (SST) images are valuable for various oceanic applications, including climate monitoring, ocean modeling, and marine ecology. However, cloud cover often obscures SST signals, creating gaps in the data that reduce resolution and hinder spatiotemporal analysis, particularly in the waters near Taiwan. Thus, gap-filling methods are crucial for reconstructing missing SST values to provide continuous and consistent data. This study introduces a gap-filling approach using the Double U-Net, a deep neural network model, pretrained on a diverse dataset of Level-4 SST images. These gap-free products are generated by blending satellite observations with numerical models and in situ measurements. The Double U-Net model excels in capturing SST dynamics and detailed spatial patterns, offering sharper representations of ocean current-induced SST patterns than the interpolated outputs of Data Interpolating Empirical Orthogonal Functions (DINEOFs). Comparative analysis with buoy observations shows the Double U-Net model’s enhanced accuracy, with better correlation results and lower error values across most study areas. By analyzing SST at five key locations near Taiwan, the research highlights the Double U-Net’s potential for high-resolution SST reconstruction, thus enhancing our understanding of ocean temperature dynamics. Based on this method, we can combine more high-resolution satellite data in the future to improve the data-filling model and apply it to marine geographic information science. Full article
(This article belongs to the Topic Advances in Earth Observation and Geosciences)
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11 pages, 364 KiB  
Article
Differential Scanning Calorimetry of Proteins and the Two-State Model: Comparison of Two Formulas
by Knarik Yeritsyan and Artem Badasyan
Biophysica 2024, 4(2), 227-237; https://doi.org/10.3390/biophysica4020016 (registering DOI) - 13 May 2024
Abstract
Differential Scanning Calorimetry (DSC) is a regular and powerful tool to measure the specific heat profile of various materials. In order to connect the measured profile to the properties of a particular protein, a model is required to fit. We discuss here the [...] Read more.
Differential Scanning Calorimetry (DSC) is a regular and powerful tool to measure the specific heat profile of various materials. In order to connect the measured profile to the properties of a particular protein, a model is required to fit. We discuss here the application of an exact two-state formula with its approximation and process the DSC experimental data on protein folding in water. The approximate formula relies on the smallness of the transition interval, which is different for each protein. With an example of the set of 33 different proteins, we show the practical validity of the approximation and the equivalence of exact and approximate two-state formulas for processing DSC data. Full article
(This article belongs to the Collection Feature Papers in Biophysics)
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18 pages, 11155 KiB  
Article
Experimental and Numerical Study of Membrane Residual Stress in Q690 High-Strength Steel Welded Box Section Compressed Member
by Jie Wang, Aimin Xu, Jin Di, Fengjiang Qin and Pengfei Men
Materials 2024, 17(10), 2296; https://doi.org/10.3390/ma17102296 (registering DOI) - 13 May 2024
Abstract
High-strength steel (HSS) members with welded sections exhibit a notably lower residual compressive stress ratio compared with common mild steel (CMS) members. Despite this difference, current codes often generalize the findings from CMS members to HSS members, and the previous unified residual stress [...] Read more.
High-strength steel (HSS) members with welded sections exhibit a notably lower residual compressive stress ratio compared with common mild steel (CMS) members. Despite this difference, current codes often generalize the findings from CMS members to HSS members, and the previous unified residual stress models are generally conservative. This study focuses on the membrane residual stress distribution in Q690 steel welded box sections. By leveraging experimental results, the influence of section sizes and welding parameters on membrane residual stress was delved into. A larger plate size correlates with a decrease in the residual compressive stress across the section, with a more pronounced reduction observed in adjacent plates. Additionally, augmenting the number of welding passes tends to diminish residual stresses across the section. Results showed that membrane residual stress adhered to the section’s self-equilibrium, while the self-equilibrium in the plates was not a uniform pattern. A reliable residual stress simulation method for Q690 steel welded box sections was established using a three-dimensional thermal–elastic–plastic finite element model (3DTEFEM) grounded in experimental data. This method served as the cornerstone for parameter analysis in this study and set the stage for subsequent research. As a result, an accurate unified residual stress model for Q690 steel welded box sections was derived. Full article
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16 pages, 2258 KiB  
Article
Consumers’ Perceptions for an Outdoor Ornamental Plant: Exploring the Influence of Novel Plant Diseases Diagnostics and Sustainable Nurseries Cultivation Management
by Michel Frem, Alessandro Petrontino, Vincenzo Fucilli, Barbara De Lucia, Emanuela Tria, Adele Annarita Campobasso, Federica Calderoni and Francesco Bozzo
Horticulturae 2024, 10(5), 501; https://doi.org/10.3390/horticulturae10050501 (registering DOI) - 13 May 2024
Abstract
A discrete choice experiment was conducted to assess the perceptions and willingness-to-pay of Italian consumers regarding plant diagnosis and sustainable cultivation attributes in outdoor ornamental plants, specifically Abelia × grandiflora. The results revealed that most Italian consumers place great importance on the [...] Read more.
A discrete choice experiment was conducted to assess the perceptions and willingness-to-pay of Italian consumers regarding plant diagnosis and sustainable cultivation attributes in outdoor ornamental plants, specifically Abelia × grandiflora. The results revealed that most Italian consumers place great importance on the health of ornamental plants during the purchasing process, with a preference for obtaining them from nursery facilities. Additionally, they demonstrated a willingness to pay a price premium for innovative plant diagnosis and sustainable cultivation in the production of A. × grandiflora, amounting to EUR 1.10 and EUR 0.90, respectively. These findings have significant implications for (i) nursery growers, enabling them to shape their sustainable nursery management and marketing strategies, and (ii) policymakers, facilitating the enhancement of communication strategies and the implementation of awareness campaigns aimed at promoting the sale of healthy Italian ornamental species, following the current EU regulation 2020/1201. Full article
13 pages, 1337 KiB  
Review
A Neoteric Approach toward Social Media in Public Health Informatics: A Narrative Review of Current Trends and Future Directions
by Asma Tahir Awan, Ana Daniela Gonzalez and Manoj Sharma
Information 2024, 15(5), 276; https://doi.org/10.3390/info15050276 (registering DOI) - 13 May 2024
Abstract
Social media has become more popular in the last few years. It has been used in public health development and healthcare settings to promote healthier lifestyles. Given its important role in today’s culture, it is necessary to understand its current trends and future [...] Read more.
Social media has become more popular in the last few years. It has been used in public health development and healthcare settings to promote healthier lifestyles. Given its important role in today’s culture, it is necessary to understand its current trends and future directions in public health. This review aims to describe and summarize how public health professionals have been using social media to improve population outcomes. This review highlights the substantial influence of social media in advancing public health objectives. The key themes explored encompass the utilization of social media to advance health initiatives, monitor diseases, track behaviors, and interact with communities. Additionally, it discusses potential future directions on how social media can be used to improve population health. The findings show how social media has been used as a tool for research, implementing health campaigns, and health promotion. Social media integration with artificial intelligence (AI) and Generative Pre-Trained Transformers (GPTs) can impact and offer an innovative approach to tackle the problems and difficulties in health informatics. The research shows how social media will keep growing and evolving and, if used effectively, has the potential to help close public health gaps across different cultures and improve population health. Full article
(This article belongs to the Special Issue Recent Advances in Social Media Mining and Analysis)
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