The 2023 MDPI Annual Report has
been released!
 
22 pages, 14306 KiB  
Article
Daily Streamflow Forecasting Using Networks of Real-Time Monitoring Stations and Hybrid Machine Learning Methods
by Yue Zhang, Zimo Zhou, Ying Deng, Daiwei Pan, Jesse Van Griensven Thé, Simon X. Yang and Bahram Gharabaghi
Water 2024, 16(9), 1284; https://doi.org/10.3390/w16091284 (registering DOI) - 30 Apr 2024
Abstract
Considering the increased risk of urban flooding and drought due to global climate change and rapid urbanization, the imperative for more accurate methods for streamflow forecasting has intensified. This study introduces a pioneering approach leveraging the available network of real-time monitoring stations and [...] Read more.
Considering the increased risk of urban flooding and drought due to global climate change and rapid urbanization, the imperative for more accurate methods for streamflow forecasting has intensified. This study introduces a pioneering approach leveraging the available network of real-time monitoring stations and advanced machine learning algorithms that can accurately simulate spatial–temporal problems. The Spatio-Temporal Attention Gated Recurrent Unit (STA-GRU) model is renowned for its computational efficacy in forecasting streamflow events with a forecast horizon of 7 days. The novel integration of the groundwater level, precipitation, and river discharge as predictive variables offers a holistic view of the hydrological cycle, enhancing the model’s accuracy. Our findings reveal that for a 7-day forecasting period, the STA-GRU model demonstrates superior performance, with a notable improvement in mean absolute percentage error (MAPE) values and R-square (R2) alongside reductions in the root mean squared error (RMSE) and mean absolute error (MAE) metrics, underscoring the model’s generalizability and reliability. Comparative analysis with seven conventional deep learning models, including the Long Short-Term Memory (LSTM), the Convolutional Neural Network LSTM (CNNLSTM), the Convolutional LSTM (ConvLSTM), the Spatio-Temporal Attention LSTM (STA-LSTM), the Gated Recurrent Unit (GRU), the Convolutional Neural Network GRU (CNNGRU), and the STA-GRU, confirms the superior predictive power of the STA-LSTM and STA-GRU models when faced with long-term prediction. This research marks a significant shift towards an integrated network of real-time monitoring stations with advanced deep-learning algorithms for streamflow forecasting, emphasizing the importance of spatially and temporally encompassing streamflow variability within an urban watershed’s stream network. Full article
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17 pages, 3871 KiB  
Article
Requirement on the Capacity of Energy Storage to Meet the 2 °C Goal
by Yifei Deng, Yijing Wang, Xiaofan Xing, Yuankang Xiong, Siqing Xu and Rong Wang
Sustainability 2024, 16(9), 3753; https://doi.org/10.3390/su16093753 (registering DOI) - 30 Apr 2024
Abstract
The inherent power fluctuations of wind, photovoltaic (PV) and bioenergy with carbon capture and storage (BECCS) create a temporal mismatch between energy supply and demand. This mismatch could lead to a potential resurgence of fossil fuels, offsetting the effects of decarbonization and affecting [...] Read more.
The inherent power fluctuations of wind, photovoltaic (PV) and bioenergy with carbon capture and storage (BECCS) create a temporal mismatch between energy supply and demand. This mismatch could lead to a potential resurgence of fossil fuels, offsetting the effects of decarbonization and affecting the realization of the Paris target by limiting global warming to below 2 °C in the 21st century. While application of energy storage is widely recommended to address this limitation, there is a research gap to quantify the impacts of energy storage limitation on global warming. Here, we analyzed the hourly variation of global wind and PV power during the period 1981–2020 and the monthly capacity of biomass production in 2019, and thus quantified the impact of decreasing the capacity of energy storage on global warming using a state-of-the-art Earth system model. We found that global warming by 2100 in the SSP1-2.6 scenario would increase by about 20% and exceed 2 °C without deploying energy storage facilities. Achieving the 2 °C target requires reducing power losses of wind and PV by at least 30% through energy storage. This requirement delivers to a cumulative storage capacity of 16.46 TWh using batteries during the period 2021–2100, leading to the international trade of cobalt and manganese across countries due to deficits of minerals at a country level. In the context of energy security, we highlight the importance of considering the limitations of energy storage and mineral shortage in the forthcoming policies of decarbonization. Full article
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19 pages, 2826 KiB  
Article
Synbiotic Bacillus megaterium DSM 32963 and n-3 PUFA Salt Composition Elevates Pro-Resolving Lipid Mediator Levels in Healthy Subjects: A Randomized Controlled Study
by Bodo Speckmann, Tanja Wagner, Paul M. Jordan, Oliver Werz, Manfred Wilhelm, Heike tom Dieck and Christiane Schön
Nutrients 2024, 16(9), 1354; https://doi.org/10.3390/nu16091354 (registering DOI) - 30 Apr 2024
Abstract
Beneficial health effects of omega-3 polyunsaturated fatty acids (n-3 PUFA) are partly attributed to specialized pro-resolving mediators (SPMs), which promote inflammation resolution. Strategies to improve n-3 PUFA conversion to SPMs may, therefore, be useful to treat or prevent chronic inflammatory [...] Read more.
Beneficial health effects of omega-3 polyunsaturated fatty acids (n-3 PUFA) are partly attributed to specialized pro-resolving mediators (SPMs), which promote inflammation resolution. Strategies to improve n-3 PUFA conversion to SPMs may, therefore, be useful to treat or prevent chronic inflammatory disorders. Here, we explored a synbiotic strategy to increase circulating SPM precursor levels. Healthy participants (n = 72) received either SynΩ3 (250 mg eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA) lysine salts; two billion CFU Bacillus megaterium; n = 23), placebo (n = 24), or fish oil (300 mg EPA plus DHA; N = 25) capsules daily for 28 days in a randomized, double-blind placebo-controlled parallel 3-group design. Biomarkers were assessed at baseline and after 2 and 28 days of intervention. The primary analysis involved the comparison between SynΩ3 and placebo. In addition, SynΩ3 was compared to fish oil. The synbiotic SynΩ3 comprising Bacillus megaterium DSM 32963 and n-3 PUFA salts significantly increased circulating SPM precursor levels, including 18-hydroxy-eicosapentaenoic acid (18-HEPE) plus 5-HEPE, which was not achieved to this extent by fish oil with a similar n-3 PUFA content. Omega-3 indices were increased slightly by both SynΩ3 and fish oil. These findings suggest reconsidering conventional n-3 PUFA supplementation and testing the effectiveness of SynΩ3 particularly in conditions related to inflammation. Full article
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16 pages, 3430 KiB  
Article
Peptide Toxins from Antarctica: The Nemertean Predator and Scavenger Parborlasia corrugatus (McIntosh, 1876)
by Erik Jacobsson, Adam A. Strömstedt, Håkan S. Andersson, Conxita Avila and Ulf Göransson
Toxins 2024, 16(5), 209; https://doi.org/10.3390/toxins16050209 (registering DOI) - 30 Apr 2024
Abstract
Peptide toxins from marine invertebrates have found use as drugs and in biotechnological applications. Many marine habitats, however, remain underexplored for natural products, and the Southern Ocean is among them. Here, we report toxins from one of the top predators in Antarctic waters: [...] Read more.
Peptide toxins from marine invertebrates have found use as drugs and in biotechnological applications. Many marine habitats, however, remain underexplored for natural products, and the Southern Ocean is among them. Here, we report toxins from one of the top predators in Antarctic waters: the nemertean worm Parborlasia corrugatus (McIntosh, 1876). Transcriptome mining revealed a total of ten putative toxins with a cysteine pattern similar to that of alpha nemertides, four nemertide-beta-type sequences, and two novel full-length parborlysins. Nemertean worms express toxins in the epidermal mucus. Here, the expression was determined by liquid chromatography combined with mass spectrometry. The findings include a new type of nemertide, 8750 Da, containing eight cysteines. In addition, we report the presence of six cysteine-containing peptides. The toxicity of tissue extracts and mucus fractions was tested in an Artemia assay. Notably, significant activity was observed both in tissue and the high-molecular-weight mucus fraction, as well as in a parborlysin fraction. Membrane permeabilization experiments display the membranolytic activity of some peptides, most prominently the parborlysin fraction, with an estimated EC50 of 70 nM. Full article
(This article belongs to the Topic Marine Biotoxins and Bioactive Marine Natural Products)
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12 pages, 2421 KiB  
Article
Phylogenomic Characterization of Ranavirus Isolated from Wild Smallmouth Bass (Micropterus dolomieu)
by Hannah Quail, Pedro H. O. Viadanna, Jordan A. Vann, Hui-Min Hsu, Andrea Pohly, Willow Smith, Scott Hansen, Nicole Nietlisbach, Danielle Godard, Thomas B. Waltzek and Kuttichantran Subramaniam
Viruses 2024, 16(5), 715; https://doi.org/10.3390/v16050715 (registering DOI) - 30 Apr 2024
Abstract
In September 2021, 14 smallmouth bass (SMB; Micropterus dolomieu) with skin lesions were collected from Green Bay waters of Lake Michigan and submitted for diagnostic evaluation. All the skin samples tested positive for largemouth bass virus (LMBV) by conventional PCR. The complete genome [...] Read more.
In September 2021, 14 smallmouth bass (SMB; Micropterus dolomieu) with skin lesions were collected from Green Bay waters of Lake Michigan and submitted for diagnostic evaluation. All the skin samples tested positive for largemouth bass virus (LMBV) by conventional PCR. The complete genome of the LMBV (99,328 bp) isolated from a homogenized skin sample was determined using an Illumina MiSeq sequencer. A maximum likelihood (ML) phylogenetic analysis based on the 21 core iridovirus genes supported the LMBV isolated from SMB (LMBV-WVL21117) as a member of the species Santee-Cooper ranavirus. Pairwise nucleotide comparison of the major capsid protein (MCP) gene showed that LMBV-WVL21117 is identical to other LMBV reported from the United States and nearly identical to doctor fish virus and guppy virus 6 (99.2%) from Southeast Asia, as well as LMBV isolates from China and Thailand (99.1%). In addition, ML phylogenetic analysis based on the MCP gene suggests three genotypes of LMBV separated by region: genotype one from the United States, genotype two from Southeast Asia, and genotype three from China and Thailand. Additional research is needed to understand the prevalence and genetic diversity of LMBV strains circulating in wild and managed fish populations from different regions. Full article
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18 pages, 4894 KiB  
Article
A Novel Spatiotemporal Periodic Polynomial Model for Predicting Road Traffic Speed
by Shan Jiang, Yuming Feng, Xiaofeng Liao, Hongjuan Wu, Jinkui Liu and Babatunde Oluwaseun Onasanya
Symmetry 2024, 16(5), 537; https://doi.org/10.3390/sym16050537 (registering DOI) - 30 Apr 2024
Abstract
Accurate and fast traffic prediction is the data-based foundation for achieving traffic control and management, and the accuracy of prediction results will directly affect the effectiveness of traffic control and management. This paper proposes a new spatiotemporal periodic polynomial model for road traffic, [...] Read more.
Accurate and fast traffic prediction is the data-based foundation for achieving traffic control and management, and the accuracy of prediction results will directly affect the effectiveness of traffic control and management. This paper proposes a new spatiotemporal periodic polynomial model for road traffic, which integrates the temporal, spatial, and periodic features of speed time series and can effectively handle the nonlinear mapping relationship from input to output. In terms of the model, we establish a road traffic speed prediction model based on polynomial regression. In terms of spatial feature extraction methods, we introduce a maximum mutual information coefficient spatial feature extraction method. In terms of periodic feature extraction methods, we introduce a periodic trend modeling method into the prediction of speed time series, and effective fusion is carried out. Four strategies are evaluated based on the Guangzhou road speed dataset: a univariate polynomial model, a spatiotemporal polynomial model, a periodic polynomial model, and a spatiotemporal periodic polynomial model. The test results show that the three methods proposed in this article can effectively improve prediction accuracy. Comparing the spatiotemporal periodic polynomial model with multiple machine learning models and deep learning models, the prediction accuracy is improved by 5.94% compared to the best feedforward neural network. The research in this article can effectively deal with the temporal, spatial, periodic, and nonlinear characteristics of speed prediction, and to a certain extent, improve the accuracy of speed prediction. Full article
(This article belongs to the Section Engineering and Materials)
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11 pages, 974 KiB  
Article
Effect of Annoying Sounds on Postural Control
by Michalina Błażkiewicz, Michalina Gulatowska, Anna Hadamus, Justyna Kędziorek and Grażyna Brzuszkiewicz-Kuźmicka
J. Clin. Med. 2024, 13(9), 2638; https://doi.org/10.3390/jcm13092638 (registering DOI) - 30 Apr 2024
Abstract
Objectives: This study aimed to explore the impact of irritating sounds on the postural control of healthy adults, considering both linear and nonlinear parameters, subjective assessments, and gender differences. Methods: Thirty-four young participants (17 females, 17 males) completed three 30 s bipedal [...] Read more.
Objectives: This study aimed to explore the impact of irritating sounds on the postural control of healthy adults, considering both linear and nonlinear parameters, subjective assessments, and gender differences. Methods: Thirty-four young participants (17 females, 17 males) completed three 30 s bipedal standing stability tests on a balance platform: one with visual control (EO), another without visual control (EC), and a third without visual control but accompanied by irritating sounds (ECS). Additionally, participants filled out a questionnaire evaluating their sound sensitivity. Linear and nonlinear parameters from each balance test were considered for statistical analysis. Results: The findings reveal significant gender-based variations in sensitivity to sound, with women exhibiting higher sensitivity. No statistically significant differences in postural control were observed between males and females, except for a notable increase in irregularity (SampEn values) in the anterior–posterior direction for females in the ECS trial. Correlation analyses revealed a moderate and statistically significant correlation between SampEn values in the AP direction and SE scores. Conclusions: This study highlights the intricate relationship between sensory stimuli, attention, and the body’s ability to maintain balance. The presence of irritating sounds led to increased irregularity in postural control, particularly in the absence of visual control. Full article
(This article belongs to the Special Issue Recent Developments in Hearing and Balance Disorders)
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18 pages, 834 KiB  
Article
A Multi-Agent Reinforcement Learning-Based Grant-Free Random Access Protocol for mMTC Massive MIMO Networks
by Felipe Augusto Dutra Bueno, Alessandro Goedtel, Taufik Abrão and José Carlos Marinello
J. Sens. Actuator Netw. 2024, 13(3), 30; https://doi.org/10.3390/jsan13030030 (registering DOI) - 30 Apr 2024
Abstract
The expected huge number of connected devices in Internet of Things (IoT) applications characterizes the massive machine-type communication (mMTC) scenario, one prominent use case of beyond fifth-generation (B5G) systems. To meet mMTC connectivity requirements, grant-free (GF) random access (RA) protocols are seen as [...] Read more.
The expected huge number of connected devices in Internet of Things (IoT) applications characterizes the massive machine-type communication (mMTC) scenario, one prominent use case of beyond fifth-generation (B5G) systems. To meet mMTC connectivity requirements, grant-free (GF) random access (RA) protocols are seen as a promising solution due to the small amount of data that MTC devices usually transmit. In this paper, we propose a GF RA protocol based on a multi-agent reinforcement learning approach, applied to aid IoT devices in selecting the least congested RA pilots. The rewards obtained by the devices in collision cases resemble the congestion level of the chosen pilot. To enable the operation of the proposed method in a realistic B5G network scenario and aiming to reduce signaling overheads and centralized processing, the rewards in our proposed method are computed by the devices taking advantage of a large number of base station antennas. Numerical results demonstrate the superior performance of the proposed method in terms of latency, network throughput, and per-device throughput compared with other protocols. Full article
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8 pages, 619 KiB  
Article
Variation in Follow-Up after Radical Cystectomy for Bladder Cancer—An Inventory Roundtable and Literature Review
by Roberto Contieri, Renate Pichler, Francesco del Giudice, Gautier Marcq, Andrea Gallioli, Simone Albisinni, Francesco Soria, David d’Andrea, Wojciech Krajewski, Diego M. Carrion, Andrea Mari, Bas W. G. van Rhijn, Marco Moschini, Benjamin Pradere and Laura S. Mertens
J. Clin. Med. 2024, 13(9), 2637; https://doi.org/10.3390/jcm13092637 (registering DOI) - 30 Apr 2024
Abstract
Background: Follow-up after radical cystectomy (RC) for bladder cancer can be divided into oncological and functional surveillance. It remains unclear how follow-up after RC should ideally be scheduled. The aim of this report was to gain insight into the organization of follow-up after [...] Read more.
Background: Follow-up after radical cystectomy (RC) for bladder cancer can be divided into oncological and functional surveillance. It remains unclear how follow-up after RC should ideally be scheduled. The aim of this report was to gain insight into the organization of follow-up after RC in Europe, for which we conducted a roundtable inventory within the EAU Young Academic Urologists Urothelial Cancer working group. Methods: An inventory semi-structured survey was performed among urologists of the EAU Young Academic Urologists Urothelial Cancer working group to describe the organization of follow-up. The surveys were analyzed using a deductive approach. Similarities and differences in follow-up after RC for bladder cancer were described. Results: The survey included 11 urologists from six different European countries. An institutional follow-up scheme was used by six (55%); three (27%) used a national or international guideline, and two (18%) indicated that there was no defined follow-up scheme. Major divergent aspects included the time points of follow-up, the frequency, and the end of follow-up. Six centers (55%) adopted a risk-adapted follow-up approach tailored to (varying) patient and tumor characteristics. Laboratory tests and CT scans were used in all cases; however, the intensity and frequency varied. Functional follow-up overlapped with oncological follow-up in terms of frequency and duration. Patient-reported outcome measures were only used by two (18%) urologists. Conclusions: Substantial variability exists across European centers regarding the follow-up after RC for bladder cancer. This highlights the need for an international analysis focusing on its organization and content as well as on opportunities to improve patients’ needs during follow-up after RC. Full article
(This article belongs to the Special Issue Clinical Therapeutic Advances in Urological Cancer)
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19 pages, 9377 KiB  
Article
Analysis of Tool Load Concerning the Cross-Sectional Size of Removed Material
by Peter Kozový, Miroslav Matuš, Vladimír Bechný, Jozef Holubják, Richard Joch and Michal Šajgalík
J. Manuf. Mater. Process. 2024, 8(3), 92; https://doi.org/10.3390/jmmp8030092 (registering DOI) - 30 Apr 2024
Abstract
High-feed milling (HFM) represents a progressive manufacturing technology that has recently found widespread application across various industries. HFM is characterized by high machining speed, reduced cycle times, increased overall productivity, and increased tool life. Due to its versatility, HFM is a suitable technology [...] Read more.
High-feed milling (HFM) represents a progressive manufacturing technology that has recently found widespread application across various industries. HFM is characterized by high machining speed, reduced cycle times, increased overall productivity, and increased tool life. Due to its versatility, HFM is a suitable technology for the application of various materials. The study deals with experimental analysis of cutting forces, machined surface integrity, and statistical evaluation in high-feed machining. In the present study, nickel-copper-based alloy (Monel) was chosen as the machined material, employing HFM with a monolithic ceramic milling cutter. The Monel material is characterized by its excellent mechanical properties and chemical resistance in harsh environments. During machining, cutting forces were recorded in three mutually perpendicular directions. This paper delves into the analysis of the impact of the depth of cut (ap), width of cut (ae), and lead-in angle (ε). The chosen evaluation characteristics encompass the tool load, primary profile, and the attained roughness of the machined surface. It is noteworthy that the technology under consideration predominantly aligns with the roughing phase of the manufacturing process. Additionally, the investigation incorporates a statistical analysis of the response surface pertaining to the cutting force components, namely Fx, Fy, Fz, and the resultant cutting force F. Full article
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14 pages, 298 KiB  
Article
There’s a Basilisk in the Bathwater: AI and the Apocalyptic Imagination
by Avery Isbrücker
Religions 2024, 15(5), 560; https://doi.org/10.3390/rel15050560 (registering DOI) - 30 Apr 2024
Abstract
Deciding what to make of secular, religious, and spiritual speculations about AI and digital technologies can be overwhelming, and focusing on the extreme utopic or dystopic outcomes may be obscuring the larger facts. Is this technology a beautiful blessing or a damning curse? [...] Read more.
Deciding what to make of secular, religious, and spiritual speculations about AI and digital technologies can be overwhelming, and focusing on the extreme utopic or dystopic outcomes may be obscuring the larger facts. Is this technology a beautiful blessing or a damning curse? What can paying close attention to these technologies and the discourse surrounding them show? How founded are our anxieties? By following the apocalyptic throughline in this rhetoric across fields in recent years, this essay seeks to consider the effect of apocalyptic thought on recent developments in tech, and consider how this worldview orients our future. The deterministically utopic, dystopic, and apocalyptic rhetoric surrounding these technologies obscures their function and efficacy, giving agency to what is functionally still just a tool, the use for which depends on its designers and users. Full article
(This article belongs to the Special Issue Theology and Science: Loving Science, Discovering the Divine)
16 pages, 7262 KiB  
Article
Phosphorus Distribution within Aggregates in Long-Term Fertilized Black Soil: Regulatory Mechanisms of Soil Organic Matter and pH as Key Impact Factors
by Naiyu Zhang, Qiong Wang, Yanhua Chen, Shuxiang Zhang, Xianmei Zhang, Gu Feng, Hongjun Gao, Chang Peng and Ping Zhu
Agronomy 2024, 14(5), 936; https://doi.org/10.3390/agronomy14050936 (registering DOI) - 30 Apr 2024
Abstract
Understanding soil phosphorus (P) distribution and its key drivers is fundamental for sustainable P management. In this study, a 21-year fertilization experiment on black soil was carried out, setting up five fertilization treatments: unfertilized control (CK), nitrogen and potassium (NK), nitrogen, P and [...] Read more.
Understanding soil phosphorus (P) distribution and its key drivers is fundamental for sustainable P management. In this study, a 21-year fertilization experiment on black soil was carried out, setting up five fertilization treatments: unfertilized control (CK), nitrogen and potassium (NK), nitrogen, P and potassium (NPK), NPK plus straw (NPKS), and NPK plus manure (NPKM). The distribution and effecting factors of P pools within soil aggregates were investigated. Compared to CK, the NK and NPK treatments decreased calcium-associated P concentration in all aggregate fractions. Meanwhile, the NPK treatment significantly increased the organic P extracted from NaOH in unaggregated particles (<0.053 mm). This was mainly due to the reduction in soil pH. The NPKS and NPKM treatments increased almost all P forms in aggregates, especially Ca-P. For the NPKM treatment, inorganic P extracted from resin, NaHCO3, and NaOH increased as aggregate size increased. This was mainly because straw or manure addition promoted soil organic carbon (SOC) storage in aggregates, creating more sorption sites via association with amorphous metallic minerals, and, thus, facilitating P accumulation. In conclusion, decreasing soil pH by chemical fertilizers is an effective strategy for mobilizing soil P, whereas increasing SOC by straw or manure facilitates P accumulation. Full article
(This article belongs to the Section Soil and Plant Nutrition)
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31 pages, 7679 KiB  
Review
Unlocking the Potential of Gold as Nanomedicine in Cancer Immunotherapy
by Panangattukara Prabhakaran Praveen Kumar, Maggie Lee and Taeho Kim
J. Nanotheranostics 2024, 5(2), 29-59; https://doi.org/10.3390/jnt5020003 (registering DOI) - 30 Apr 2024
Abstract
Nanotechnology advancements have resulted in many sensors and devices for biomedical applications. Among the various nanomaterials, gold nanoparticles (AuNPs), due to their size, shape, biocompatibility, and unique plasmonic property, are an excellent candidate for many biomedical applications. AuNPs, known for their easy surface [...] Read more.
Nanotechnology advancements have resulted in many sensors and devices for biomedical applications. Among the various nanomaterials, gold nanoparticles (AuNPs), due to their size, shape, biocompatibility, and unique plasmonic property, are an excellent candidate for many biomedical applications. AuNPs, known for their easy surface modifications, robust nature, and photothermal activities, find application in drug delivery and cancer treatment studies. In this review, we are highlighting the recent trends in using AuNPs as nanomedicine for cancer immunotherapy. Cancer immunotherapy not only eliminates the primary tumors but also allows for the treatment of metastasis along with the recurrence of the tumor. AuNPs possess tissue-specific delivery functions that depend on the tunability in size and surface functionalization of AuNPs. AuNPs can be used to activate the tumor’s immune defense ability, or they can be used to enhance the anti-tumor immune response. Understanding the interaction of the tumor environment and nanobiomedicine is very important. In the present review, we give an idea of the mode of action of AuNPs and various combinations of therapies for cancer immunotherapy. Full article
(This article belongs to the Special Issue Interventional Nanotheranostics for Translational Nano-Immunotherapy)
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17 pages, 1120 KiB  
Article
Modeling the Impact of Misinformation on the Transmission Dynamics of COVID-19
by Ziyi Su and Ephraim Agyingi
AppliedMath 2024, 4(2), 544-560; https://doi.org/10.3390/appliedmath4020029 (registering DOI) - 30 Apr 2024
Abstract
The threat posed by the COVID-19 pandemic has been accompanied by an epidemic of misinformation, causing confusion and mistrust among the public. Misinformation about COVID-19 whether intentional or unintentional takes many forms, including conspiracy theories, false treatments, and inaccurate information about the origins [...] Read more.
The threat posed by the COVID-19 pandemic has been accompanied by an epidemic of misinformation, causing confusion and mistrust among the public. Misinformation about COVID-19 whether intentional or unintentional takes many forms, including conspiracy theories, false treatments, and inaccurate information about the origins and spread of the virus. Though the pandemic has brought to light the significant impact of misinformation on public health, mathematical modeling emerged as a valuable tool for understanding the spread of COVID-19 and the impact of public health interventions. However, there has been limited research on the mathematical modeling of the spread of misinformation related to COVID-19. In this paper, we present a mathematical model of the spread of misinformation related to COVID-19. The model highlights the challenges posed by misinformation, in that rather than focusing only on the reproduction number that drives new infections, there is an additional threshold parameter that drives the spread of misinformation. The equilibria of the model are analyzed for both local and global stability, and numerical simulations are presented. We also discuss the model’s potential to develop effective strategies for combating misinformation related to COVID-19. Full article
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11 pages, 3764 KiB  
Article
Enhancing the Uniformity of a Memristor Using a Bilayer Dielectric Structure
by Yulin Liu, Qilai Chen, Yanbo Guo, Bingjie Guo, Gang Liu, Yanchao Liu, Lei He, Yutong Li, Jingyan He and Minghua Tang
Micromachines 2024, 15(5), 605; https://doi.org/10.3390/mi15050605 (registering DOI) - 30 Apr 2024
Abstract
Resistive random access memory (RRAM) holds great promise for in-memory computing, which is considered the most promising strategy for solving the von Neumann bottleneck. However, there are still significant problems in its application due to the non-uniform performance of RRAM devices. In this [...] Read more.
Resistive random access memory (RRAM) holds great promise for in-memory computing, which is considered the most promising strategy for solving the von Neumann bottleneck. However, there are still significant problems in its application due to the non-uniform performance of RRAM devices. In this work, a bilayer dielectric layer memristor was designed based on the difference in the Gibbs free energy of the oxide. We fabricated Au/Ta2O5/HfO2/Ta/Pt (S3) devices with excellent uniformity. Compared with Au/HfO2/Pt (S1) and Au/Ta2O5/Pt (S2) devices, the S3 device has a low reset voltage fluctuation of 2.44%, and the resistive coefficients of variation are 13.12% and 3.84% in HRS and LRS, respectively, over 200 cycles. Otherwise, the bilayer device has better linearity and more conductance states in multi-state regulation. At the same time, we analyze the physical mechanism of the bilayer device and provide a physical model of ion migration. This work provides a new idea for designing and fabricating resistive devices with stable performance. Full article
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20 pages, 4458 KiB  
Article
Beyond the Beach: Multi-Parameter Interpretation of Shore Deterioration in a Caribbean Reef System
by Laura R. de Almeida, S. Valery Ávila-Mosqueda, Edgar Mendoza, Brigitta I. van Tussenbroek and Rodolfo Silva
Diversity 2024, 16(5), 266; https://doi.org/10.3390/d16050266 (registering DOI) - 30 Apr 2024
Abstract
Throughout the Caribbean region, coastal areas are of vital importance for national incomes from the tourism industry. However, accelerated coastal development has impacted the coastal ecosystems, including the beaches, and deterioration of the shore results from cumulative impacts on both marine and coastal [...] Read more.
Throughout the Caribbean region, coastal areas are of vital importance for national incomes from the tourism industry. However, accelerated coastal development has impacted the coastal ecosystems, including the beaches, and deterioration of the shore results from cumulative impacts on both marine and coastal ecosystems. It is essential to identify the areas that need special attention for targeted management plans and actions, especially in areas with high anthropogenic pressure. This research proposes an integrated assessment of the conservation state of shore and coastal ecosystems in the Puerto Morelos National Reef Park (PNAPM) in the Mexican Caribbean, through the spatial monitoring of key parameters. A Geographic Information System (GIS) was employed to analyze the land use on the shore, foredune condition, morphological characteristics of the beaches, shoreline evolution, and the condition of coral reefs and seagrass meadows. The analysis identified the most critical areas in relation to shore deterioration and priority areas for the preservation of ecosystems. The spatial data obtained for the PNAPM can serve as a basis for ongoing shore monitoring, and targeted management actions through the designation of areas that require either preservation or ecosystem restoration practices. This methodology can be applied to other reef systems in the Caribbean. Full article
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17 pages, 1260 KiB  
Article
Characterization of Phenolic Compounds in Extra Virgin Olive Oil from Granada (Spain) and Evaluation of Its Neuroprotective Action
by María Asunción López-Bascón, Inmaculada Moscoso-Ruiz, Rosa Quirantes-Piné, Raquel del Pino-García, Gloria López-Gámez, Andrea Justicia-Rueda, Vito Verardo and José L. Quiles
Int. J. Mol. Sci. 2024, 25(9), 4878; https://doi.org/10.3390/ijms25094878 (registering DOI) - 30 Apr 2024
Abstract
The olive oil sector is a fundamental food in the Mediterranean diet. It has been demonstrated that the consumption of extra virgin olive oil (EVOO) with a high content of phenolic compounds is beneficial in the prevention and/or treatment of many diseases. The [...] Read more.
The olive oil sector is a fundamental food in the Mediterranean diet. It has been demonstrated that the consumption of extra virgin olive oil (EVOO) with a high content of phenolic compounds is beneficial in the prevention and/or treatment of many diseases. The main objective of this work was to study the relationship between the content of phenolic compounds and the in vitro neuroprotective and anti-inflammatory activity of EVOOs from two PDOs in the province of Granada. To this purpose, the amounts of phenolic compounds were determined by liquid chromatography coupled to mass spectrometry (HPLC–MS) and the inhibitory activity of acetylcholinesterase (AChE) and cyclooxygenase-2 (COX-2) enzymes by spectrophotometric and fluorimetric assays. The main families identified were phenolic alcohols, secoiridoids, lignans, flavonoids, and phenolic acids. The EVOO samples with the highest total concentration of compounds and the highest inhibitory activity belonged to the Picual and Manzanillo varieties. Statistical analysis showed a positive correlation between identified compounds and AChE and COX-2 inhibitory activity, except for lignans. These results confirm EVOO’s compounds possess neuroprotective potential. Full article
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19 pages, 2086 KiB  
Article
Sexual Orientation, Health, and Well-Being in Spanish People
by Roberto Matías and M. Pilar Matud
Healthcare 2024, 12(9), 924; https://doi.org/10.3390/healthcare12090924 (registering DOI) - 30 Apr 2024
Abstract
Although several studies have found disparities in health outcomes between heterosexual and lesbian, gay, and bisexual (LGB)-identifying individuals, few studies have focused on subjective well-being and protective factors for health and well-being. The purpose of this work is twofold: (1) to examine the [...] Read more.
Although several studies have found disparities in health outcomes between heterosexual and lesbian, gay, and bisexual (LGB)-identifying individuals, few studies have focused on subjective well-being and protective factors for health and well-being. The purpose of this work is twofold: (1) to examine the relevance of sexual orientation to health and well-being in women and men; (2) to identify protective and risk factors for psychological distress, self-rated health, and well-being for gay men, lesbian women, bisexual women and men, and heterosexual women and men. The sample consisted of 908 women and 586 men from the general Spanish population aged 16–64, half of whom identified themselves as LGB and half as heterosexual. All were assessed using eight questionnaires and inventories. The results showed that differences varied depending on the health indicator considered. In general, bisexuals had the poorest health, with lower self-rated health and lower self-esteem. In all groups, self-esteem was a protective factor against psychological distress and was associated with better health and well-being. To a lesser extent, social support served as a protective factor against psychological distress and was associated with greater well-being in all groups. It is concluded that although sexual orientation is relevant to the health and well-being of individuals, there are differences among sexual minorities, with bisexuals having lower self-esteem than homosexuals. Full article
(This article belongs to the Special Issue Psychology in Sex and Gender)
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26 pages, 4941 KiB  
Article
Constructing the Buddha’s Life in Early Buddhist Monastic Arrangements at Nagarjunakonda
by Young-Jae Kim
Religions 2024, 15(5), 559; https://doi.org/10.3390/rel15050559 (registering DOI) - 30 Apr 2024
Abstract
This study investigates the rationale behind the combination of Buddha mahāstūpas (mahācetiyas) and cetiyas (caityas) within a Buddhist monastery. In integrating a broader intellectual program, the universality of the concept is exemplified, wherein “mahācetiya and cetiya” are combined to symbolize the life of [...] Read more.
This study investigates the rationale behind the combination of Buddha mahāstūpas (mahācetiyas) and cetiyas (caityas) within a Buddhist monastery. In integrating a broader intellectual program, the universality of the concept is exemplified, wherein “mahācetiya and cetiya” are combined to symbolize the life of Buddha through architectural arrangements. Adopting a broader intellectual program grounded in the causality principle signifies an inclination toward universality. These combinations represent sacred places and events in Buddha’s life, from birth to Mahaparinirvana. They encompass significant moments, such as great departures, meditation, enlightenment, and preaching. The synthesis of mahācetiyas and apsidal shrines was a pivotal moment at the site, guided by the Mahāsaṅghika School, representing an innovative invention in the pursuit of narrative framing of Buddha’s biography. Full article
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15 pages, 5025 KiB  
Article
High-Throughput Phenotyping for the Evaluation of Agronomic Potential and Root Quality in Tropical Carrot Using RGB Sensors
by Fernanda Gabriela Teixeira Coelho, Gabriel Mascarenhas Maciel, Ana Carolina Silva Siquieroli, Rodrigo Bezerra de Araújo Gallis, Camila Soares de Oliveira, Ana Luisa Alves Ribeiro and Lucas Medeiros Pereira
Agriculture 2024, 14(5), 710; https://doi.org/10.3390/agriculture14050710 (registering DOI) - 30 Apr 2024
Abstract
The objective of this study was to verify the genetic dissimilarity and validate image phenotyping using RGB (red, green, and blue) sensors in tropical carrot germplasms. The experiment was conducted in the city of Carandaí-MG, Brazil, using 57 tropical carrot entries from Seminis [...] Read more.
The objective of this study was to verify the genetic dissimilarity and validate image phenotyping using RGB (red, green, and blue) sensors in tropical carrot germplasms. The experiment was conducted in the city of Carandaí-MG, Brazil, using 57 tropical carrot entries from Seminis and three commercial entries. The entries were evaluated agronomically and two flights with Remotely Piloted Aircraft (RPA) were conducted. Clustering was performed to validate the existence of genetic variability among the entries using an artificial neural network to produce a Kohonen’s self-organizing map. The genotype–ideotype distance index was used to verify the best entries. Genetic variability among the tropical carrot entries was evidenced by the formation of six groups. The Brightness Index (BI), Primary Colors Hue Index (HI), Overall Hue Index (HUE), Normalized Green Red Difference Index (NGRDI), Soil Color Index (SCI), and Visible Atmospherically Resistant Index (VARI), as well as the calculated areas of marketable, unmarketable, and total roots, were correlated with agronomic characters, including leaf blight severity and root yield. This indicates that tropical carrot materials can be indirectly evaluated via remote sensing. Ten entries were selected using the genotype–ideotype distance (2, 15, 16, 22, 34, 37, 39, 51, 52, and 53), confirming the superiority of the entries. Full article
(This article belongs to the Section Genotype Evaluation and Breeding)
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18 pages, 620 KiB  
Article
The Influence Mechanism of Online Social Network Relationships on Sustainable Entrepreneurial Success
by Xianhuan Chen, Yiming Ma and Yuguang Xie
Sustainability 2024, 16(9), 3755; https://doi.org/10.3390/su16093755 (registering DOI) - 30 Apr 2024
Abstract
Affected by economic uncertainty, the success rate of sustainable entrepreneurship is not optimistic at present. Effectively improving the success rate of sustainable entrepreneurship is of great significance for ensuring and maintaining sustainable development for long-term socioeconomic and environmental sustainability. Based on social network [...] Read more.
Affected by economic uncertainty, the success rate of sustainable entrepreneurship is not optimistic at present. Effectively improving the success rate of sustainable entrepreneurship is of great significance for ensuring and maintaining sustainable development for long-term socioeconomic and environmental sustainability. Based on social network theory, entrepreneurial capital theory, psychological capital theory, and the literature on sustainable entrepreneurship, this study explores the influence mechanism of online social network relationships on sustainable entrepreneurial success from the perspective of those relationships, dividing entrepreneurs’ abilities into an online relationship-building ability and online relationship coordination ability. We used an empirical study with 346 valid questionnaires. The results of a PLS-SEM analysis show that online social network relationships have a significant impact on sustainable entrepreneurial capital, in which online relationship-building capacity has a similar impact on both sustainable entrepreneurial resource integration and acquisition; online relationship-building capacity can positively affect both transactional and interpersonal psychological capital; sustainable entrepreneurial resource integration can be more effective than resource acquisition in promoting sustainable entrepreneurial success through the use of social media; and transactional psychological capital has a more significant impact on sustainable entrepreneurial success than does interpersonal psychological capital. This study provides new insights into how entrepreneurs can fully utilize their online social network relationships to achieve entrepreneurial success. Full article
(This article belongs to the Special Issue Sustainable Entrepreneurship during Economic Uncertainty)
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17 pages, 7237 KiB  
Data Descriptor
A Comprehensive Dataset of the Aerodynamic and Geometric Coefficients of Airfoils in the Public Domain
by Kanak Agarwal, Vedant Vijaykrishnan, Dyutit Mohanty and Manikandan Murugaiah
Data 2024, 9(5), 64; https://doi.org/10.3390/data9050064 (registering DOI) - 30 Apr 2024
Abstract
This study presents an extensive collection of data on the aerodynamic behavior at a low Reynolds number and geometric coefficients for 2900 airfoils obtained through the class shape transformation (CST) method. By employing a verified OpenFOAM-based CFD simulation framework, lift and drag coefficients [...] Read more.
This study presents an extensive collection of data on the aerodynamic behavior at a low Reynolds number and geometric coefficients for 2900 airfoils obtained through the class shape transformation (CST) method. By employing a verified OpenFOAM-based CFD simulation framework, lift and drag coefficients were determined at a Reynolds number of 105. Considering the limited availability of data on low Reynolds number airfoils, this dataset is invaluable for a wide range of applications, including unmanned aerial vehicles (UAVs) and wind turbines. Additionally, the study offers a method for automating CFD simulations that could be applied to obtain aerodynamic coefficients at higher Reynolds numbers. The breadth of this dataset also supports the enhancement and creation of machine learning (ML) models, further advancing research into the aerodynamics of airfoils and lifting surfaces. Full article
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18 pages, 796 KiB  
Review
The Variety of Mechanosensitive Ion Channels in Retinal Neurons
by Ji-Jie Pang
Int. J. Mol. Sci. 2024, 25(9), 4877; https://doi.org/10.3390/ijms25094877 (registering DOI) - 30 Apr 2024
Abstract
Alterations in intraocular and external pressure critically involve the pathogenesis of glaucoma, traumatic retinal injury (TRI), and other retinal disorders, and retinal neurons have been reported to express multiple mechanical-sensitive channels (MSCs) in recent decades. However, the role of MSCs in visual functions [...] Read more.
Alterations in intraocular and external pressure critically involve the pathogenesis of glaucoma, traumatic retinal injury (TRI), and other retinal disorders, and retinal neurons have been reported to express multiple mechanical-sensitive channels (MSCs) in recent decades. However, the role of MSCs in visual functions and pressure-related retinal conditions has been unclear. This review will focus on the variety and functional significance of the MSCs permeable to K+, Na+, and Ca2+, primarily including the big potassium channel (BK); the two-pore domain potassium channels TRAAK and TREK; Piezo; the epithelial sodium channel (ENaC); and the transient receptor potential channels vanilloid TRPV1, TRPV2, and TRPV4 in retinal photoreceptors, bipolar cells, horizontal cells, amacrine cells, and ganglion cells. Most MSCs do not directly mediate visual signals in vertebrate retinas. On the other hand, some studies have shown that MSCs can open in physiological conditions and regulate the activities of retinal neurons. While these data reasonably predict the crossing of visual and mechanical signals, how retinal light pathways deal with endogenous and exogenous mechanical stimulation is uncertain. Full article
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