The scientific claim that psychedelic drugs like psilocybin reliably occasion mystical experiences was justified using the Mystical Experiences Questionnaire (the MEQ), a survey first developed in the 1960s by Walter Pahnke using W.T. Stace’s Mysticism and Philosophy. Scholars in Christian mysticism reject the adequacy of Stace’s work for Western theistic mysticism, especially Christianity. One objection is that Stace follows William James in focusing on intense and unusual moments of mystical experience rather than the somewhat more ordinary mystical life. A greater concern is that Stace more adequately reflects non-Western traditions than Western theistic traditions like Christianity. For Stace, mysticism centers on the concept of union with external reality or with the absolute, a union in which the human creature is absorbed or fused. Christian mysticism, by contrast, involves a sense of presence rather than union, experienced in a most intimate relationship as a felt loving closeness with the divine, but not as fusion or absorption into the divine. While love of God is central to the Christian view, it is ignored in Stace and the MEQ30. Finally for Christianity, mysticism is not found in the momentary experience, but in the lifelong interpretation that leads to transformation. Full article

The rice–crayfish co-culture system, a representative of Agri-aqua food systems, has emerged worldwide as an effective strategy for enhancing agricultural land use efficiency and boosting sustainability, particularly in China and Southeast Asia. Despite its widespread adoption in China’s Jianghan Plain, the exact spatiotemporal dynamics and factors influencing this practice in this region are yet to be clarified. Therefore, understanding the spatiotemporal dynamics and influencing factors of the rice–crayfish fields (RCFs) is crucial for promoting the rice–crayfish co-culture system, and optimizing land use policies. In this study, we identified the spatial distribution of RCF using Sentinel-2 images and land use spatiotemporal data to analyze its spatiotemporal dynamics during the period of 2016–2020. Additionally, we used the Multiscale Geographically Weighted Regression model to explore the key factors influencing RCF’s spatiotemporal changes. Our findings reveal that (1). the RCF area in Jianghan Plain expanded from 1216.04 km² to 2429.76 km² between 2016 and 2020, marking a 99.81% increase. (2). RCF in Jianghan Plain evolved toward a more contiguous and clustered spatial pattern, suggesting a clear industrial agglomeration in this area. (3). The expansion of the RCFs was majorly influenced by its landscape and local agricultural conditions. Significantly, the Aggregation and Landscape Shape Indexes positively impacted this expansion, whereas proximity to rural areas and towns had a negative impact. This study provides a solid foundation for promoting the rice–crayfish co-culture system and sustainably developing related industries. To ensure the sustainable development of rice–crayfish co-culture industries in Jianghan Plain, we recommend that local governments optimize the spatial layout of rural settlements, improve transportation infrastructure, and enhance regional agricultural water sources and irrigation system construction, all in line with the national strategy of rural revitalization and village planning. Additionally, promoting the concentration and contiguity of RCF through land consolidation can achieve efficient development of these industries. Full article

Background: WCFA19 (Weissella confusa WIKIM51), found during the fermentation of kimchi, is known for its inhibitory effects on body weight and body fat. This study looked at the impact of WCFA19 isolated from dandelion kimchi on weight loss in overweight and obese adults that are otherwise healthy. Methods: This study was conducted as a multicenter, double-blind, randomized, placebo-controlled study with 104 overweight and obese subjects. Subjects were randomized evenly into the test group (WCFA19, 500 mg, n = 40) or control group (n = 34) for 12 weeks from 14 June 2021 to 24 December 2021. Effects were based on DEXA to measure changes in body fat mass and percentage. Results: Among the 74 subjects analyzed, WCFA19 oral supplementation for 12 weeks resulted in a significant decrease in body fat mass of 633.38 ± 1396.17 g (p = 0.0066) in overweight and obese individuals in the experimental group. The control group showed an increase of 59.10 ± 1120.57 g (p = 0.7604), indicating a statistically significant difference between the two groups. There was also a statistically significant difference (p = 0.0448) in the change in body fat percentage, with a decrease of 0.41 ± 1.22% (p = 0.0424) in the experimental group and an increase of 0.17 ± 1.21% (p = 0.4078) in the control group. No significant adverse events were reported. Conclusions: Oral supplementation of 500 mg of WCFA19 for 12 weeks is associated with a decrease in body weight, particularly in body fat mass and percentage. Full article

The effect of sand and dust pollution on the sensitive structures of flow sensors in microelectromechanical systems (MEMS) is a hot issue in current MEMS reliability research. However, previous studies on sand and dust contamination have only searched for sensor accuracy degradation due to heat conduction in sand and dust cover and have yet to search for other failure-inducing factors. This paper aims to discover the other inducing factors for the accuracy failure of MEMS flow sensors under sand and dust pollution by using a combined model simulation and sample test method. The accuracy of a flow sensor is mainly reflected by the size of its thermistor, so in this study, the output value of the thermistor value was chosen as an electrical characterization parameter to verify the change in the sensor’s accuracy side by side. The results show that after excluding the influence of heat conduction, when sand particles fall on the device, the mutual friction between the sand particles will produce an electrostatic current; through the principle of electrostatic dissipation into the thermistor, the principle of measurement leads to the resistance value becoming smaller, and when the sand dust is stationary for some time, the resistance value returns to the expected level. This finding provides theoretical guidance for finding failure-inducing factors in MEMS failure modes. Full article

Transcranial magnetic stimulation coupled with electroencephalography (TMS-EEG) is a novel technique to investigate cortical physiology in health and disease. The cerebellum has recently gained attention as a possible new hotspot in the field of TMS-EEG, with several reports published recently. However, EEG responses obtained by cerebellar stimulation vary considerably across the literature, possibly due to different experimental methods. Compared to conventional TMS-EEG, which involves stimulation of the cortex, cerebellar TMS-EEG presents some technical difficulties, including strong muscle twitches in the neck area and a loud TMS click when double-cone coils are used, resulting in contamination of responses by electromyographic activity and sensory potentials. Understanding technical difficulties and limitations is essential for the development of cerebellar TMS-EEG research. In this review, we summarize findings of cerebellar TMS-EEG studies, highlighting limitations in experimental design and potential issues that can result in discrepancies between experimental outcomes. Lastly, we propose a possible direction for academic and clinical research with cerebellar TMS-EEG. Full article

To weaken or avoid the impact of dynamic threats such as wind and extreme weather on the real-time path of a UAV swarm, a path-planning method based on improved long short-term memory (LSTM) network prediction parameters was constructed. First, models were constructed for wind, static threats, and dynamic threats during the flight of the drone. Then, it was found that atmospheric parameters are typical time series data with spatial correlation. The LSTM network was optimized and used to process time series parameters to construct a network for predicting atmospheric parameters. The state of the drone was adjusted in real time based on the prediction results to mitigate the impact of wind or avoid the threat of extreme weather. Finally, a path optimization method based on an improved LSTM network was constructed. Through simulation, it can be seen that compared to the path that does not consider atmospheric effects, the optimized path has significantly improved flightability and safety. Full article

The control of the asymmetric shape of strips has always been an important and difficult part of the production of cold rolling strips. In this paper, the S6-High cold rolling mill is taken as the research object. A finite element model of this mill is constructed using ABAQUS 2022 software, and a multistage working condition simulation analysis is carried out. The independent effects of asymmetric Intermediate Roll Bending (IRB) and asymmetric Intermediate Roll Shifting (IRS) on the strip shape are investigated by constructing an asymmetric convexity evaluation index. The equivalent relationship between the asymmetric roll bending and the asymmetric roll shifting was determined by analysing the coupling effect of the benchmark bending and shifting rollers on their asymmetric shape control characteristics. The on-site application shows that optimizing the amount of preset asymmetric shape control can significantly improve the asymmetric situation of the shape, providing theoretical guidance for the asymmetric shape control of the S6-High cold rolling mill. Full article

Chickens are a major source of meat and eggs in human food and have significant economic value. Cadmium (Cd) is a common environmental pollutant that can contaminate feed and drinking water, leading to kidney injury in livestock and poultry, primarily by inducing the generation of free radicals. It is necessary to develop potential medicines to prevent and treat Cd-induced nephrotoxicity in poultry. Luteolin (Lut) is a natural flavonoid compound mainly extracted from peanut shells and has a variety of biological functions to defend against oxidative damage. In this study, we aimed to demonstrate whether Lut can alleviate kidney injury under Cd exposure and elucidate the underlying molecular mechanisms. Renal histopathology and cell morphology were observed. The indicators of renal function, oxidative stress, DNA damage and repair, NAD⁺ content, SIRT1 activity, and autophagy were analyzed. In vitro data showed that Cd exposure increased ROS levels and induced oxidative DNA damage and repair, as indicated by increased 8-OHdG content, increased $\mathsf{\gamma }$-H2AX protein expression, and the over-activation of the DNA repair enzyme PARP-1. Cd exposure decreased NAD⁺ content and SIRT1 activity and increased LC3 II, ATG5, and particularly p62 protein expression. In addition, Cd-induced oxidative DNA damage resulted in PARP-1 over-activation, reduced SIRT1 activity, and autophagic flux blockade, as evidenced by reactive oxygen species scavenger NAC application. The inhibition of PARP-1 activation with the pharmacological inhibitor PJ34 restored NAD⁺ content and SIRT1 activity. The activation of SIRT1 with the pharmacological activator RSV reversed Cd-induced autophagic flux blockade and cell injury. In vivo data demonstrated that Cd treatment caused the microstructural disruption of renal tissues, reduced creatinine, and urea nitrogen clearance, raised MDA content, and decreased the activities or contents of antioxidants (GSH, T-SOD, CAT, and T-AOC). Cd treatment caused oxidative DNA damage and PARP-1 activation, decreased NAD⁺ content, decreased SIRT1 activity, and impaired autophagic flux. Notably, the dietary Lut supplement observably alleviated these alterations in chicken kidney tissues induced by Cd. In conclusion, the dietary Lut supplement alleviated Cd-induced chicken kidney injury through its potent antioxidant properties by relieving the oxidative DNA damage-activated PARP-1-mediated reduction in SIRT1 activity and repairing autophagic flux blockade. Full article

Seventeen adamantane derivatives were synthesized according to facile condensation reaction protocols. Spectral analysis (¹H NMR and ¹³C NMR) was applied to confirm the chemical structure of the obtained substances. The synthesized compounds were tested for in vitro antimicrobial activity against a panel of Gram-positive and Gram-negative bacterial strains and towards fungi from Candida spp. Among them, four derivatives numbered 9, 14, 15 and 19 showed the highest antibacterial potential with MIC = 62.5–1000 µg/mL with respect to all Gram-positive bacteria. S. epidermidis ATCC 12228 was the most susceptible among the tested bacterial strains and C. albicans ATCC 10231 among fungi. Additionally, the cytotoxicity for three derivatives was measured with the use of the MTT test on A549, T47D, L929 and HeLa cell lines. Our cytotoxicity studies confirmed that the tested substances did not cause statistically significant changes in cell proliferation within the range of the tested doses. Full article

Studies have demonstrated the potential of satellite thermal infrared observations to detect anomalous signals preceding large earthquakes. However, the lack of well-defined precursory characteristics and inherent complexity and stochasticity of the seismicity continue to impede robust earthquake forecasts. This study investigates the potential of pre-seismic thermal anomalies, derived from five satellite-based geophysical parameters, i.e., skin temperature, air temperature, total integrated column water vapor burden, outgoing longwave radiation (OLR), and clear-sky OLR, as valuable indicators for global earthquake forecasts. We employed a spatially self-adaptive multiparametric anomaly identification scheme to refine these anomalies, and then estimated the posterior probability of an earthquake occurrence given observed anomalies within a Bayesian framework. Our findings reveal a promising link between thermal signatures and global seismicity, with elevated forecast probabilities exceeding 0.1 and significant probability gains in some strong earthquake-prone regions. A time series analysis indicates probability stabilization after approximately six years. While no single parameter consistently dominates, each contributes precursory information, suggesting a promising avenue for a multi-parametric approach. Furthermore, novel anomaly indices incorporating probabilistic information significantly reduce false alarms and improve anomaly recognition. Despite remaining challenges in developing dynamic short-term probabilities, rigorously testing detection algorithms, and improving ensemble forecast strategies, this study provides compelling evidence for the potential of thermal anomalies to play a key role in global earthquake forecasts. The ability to reliably estimate earthquake forecast probabilities, given the ever-present threat of destructive earthquakes, holds considerable societal and ecological importance for mitigating earthquake risk and improving preparedness strategies. Full article

Aim and background: Periapical lesions, which occur due to the infection and necrosis of dental pulp, are a significant dental pathology that poses risks to oral and systemic health. These lesions often require interventions such as root canal treatment or periapical surgery. Recent research has focused on the effectiveness of biocompatible materials, including mineral trioxide aggregate, bioceramics, and leukocyte-platelet-rich fibrin (L’PRF), in improving healing outcomes. This report presents the application of leukocyte-platelet-rich fibrin (L’PRF) derived from the patient’s autologous blood to enhance bone healing. Case description: A 61-year-old woman with well-controlled hypertension and good oral hygiene visited the dental clinic due to a painless swelling near her upper left central incisor. After examination, it was determined that she had a periapical granuloma. The patient underwent successful root canal retreatment and apical surgery, during which leukocyte-platelet-rich fibrin was applied. After 30 months, she experienced significant improvement with no symptoms and substantial bone regeneration. Conclusion: Clinical evidence and this case study indicate that leukocyte-platelet-rich fibrin (L’PRF) may enhance healing post periapical surgery. Further research, including more extensive and longer-term randomized trials, must confirm L’PRF’s effectiveness and refine treatment protocols. Clinical significance: L’PRF enhances bone healing post periapical surgery. Clinicians should consider integrating L’PRF in periapical surgeries, ensure diligent follow-up, and inform patients of its long-term advantages. Further randomized trials are needed to refine L’PRF clinical guidelines. Full article

Many Saudi students lack the motivation to pursue STEM careers due to their teachers’ limited experience and low efficacy in teaching science, technology, engineering, and mathematics (STEM). Teachers’ perceptions are central to efficient STEM education; however, little is known about the perceptions of teachers toward STEM education in Saudi Arabia. Therefore, this study attempted to identify the perceptions of secondary stage science teachers toward STEM education and their knowledge about the requirements for its implementation. The study also investigated whether there were statistically significant differences that could be attributed to teachers’ qualifications, years of experience, and specialization variables. A questionnaire was applied to 175 in-service science teachers. The results showed that the secondary stage science teachers had a medium level of positive perceptions toward STEM education and a high level of knowledge about the requirements for its implementation. It was also revealed that there were statistically significant differences in teachers’ perceptions due to their qualifications and years of experience, in favor of teachers with graduate degrees and with more years of experience, while there were no statistically significant differences due to teachers’ specialization. Based on the findings of this study, a number of recommendations on improving science teachers’ knowledge of STEM education and the requirements for its implementation are provided. Full article

Sustainable and balanced territory development involves management and planning based on the cultural and natural values that characterise it. In contrast to solutions based exclusively on quantitative growth, today, we defend qualitative territorial planning based on specific characteristics and identity what, ultimately, is the heritage content and significance of the territory. In line with these arguments, this article reflects on the need to design territorial planning strategies to activate territories with low demographic density through their heritage and landscape values, specifically referring to rural areas made up of small, scattered population centres. The wide territorial dispersion of these settlements, which represent a large proportion of Latin American and European territory, calls for specific planning and management models and criteria. This article proposes a territorial strategy for these sites aimed at sustainable tourism activation through itineraries and potential identity facilities. The application of the strategy is shown in a pilot case study of the island of Fuerteventura (Canary Islands, Spain). Full article

This work employs the Birnbaum–Saunders distribution to model the fatigue-life of metallic materials under cyclic loading and compares it with the normal distribution. Fatigue-limit models are fitted to three datasets of unnotched specimens of 75S-T6 aluminum alloys and carbon laminate with different loading types. A new equivalent stress definition that accounts for the effect of the experiment type is proposed. The results show that the Birnbaum–Saunders distribution consistently outperforms the normal distribution in fitting the fatigue data and provides more accurate predictions of fatigue-life and survival probability. Full article

To date, there have been no review articles specifically relating to the general efficacy and safety of coenzyme Q10 (CoQ10) supplementation in younger subjects. In this article, we therefore reviewed the efficacy and safety of CoQ10 supplementation in neonates (less than 1 month of age), infants (up to 1 year of age) and children (up to 12 years of age). As there is no rationale for the supplementation of CoQ10 in normal younger subjects (as there is in otherwise healthy older subjects), all of the articles in the medical literature reviewed in the present article therefore refer to the supplementation of CoQ10 in younger subjects with a variety of clinical disorders; these include primary CoQ10 deficiency, acyl CoA dehydrogenase deficiency, Duchenne muscular dystrophy, migraine, Down syndrome, ADHD, idiopathic cardiomyopathy and Friedreich’s ataxia. Full article

Systemic AL amyloidosis is a challenging disease for which many patients are considered frail in daily clinical practice. However, no study has so far addressed frailty and its impact on the outcome of these patients. We built a simple score to predict mortality based on three frailty-associated variables: age, ECOG performance status (<2 vs. ≥2) and NT-proBNP (<8500 vs. ≥8500 ng/L). Four-hundred and sixteen consecutive newly diagnosed patients diagnosed at ten sites from the Spanish Myeloma Group were eligible for the study. The score was developed in a derivation cohort from a referral center, and it was externally validated in a multicenter cohort. Multivariate analysis showed that the three variables were independent predictors of survival. The score was able to discriminate four groups of patients in terms of overall survival and early mortality in both cohorts. Comorbidity was also analyzed with the Charlson comorbidity index, but it did not reach statistical significance in the model. A nomogram was created to easily estimate the mortality risk of each patient at each time point. This score is a simple, robust, and efficient approach to dynamically assess frailty-dependent mortality both at diagnosis and throughout follow-up. The optimal treatment for frail AL amyloidosis patients remains to be determined but we suggest that the estimation of frailty-associated risk could complement current staging systems, adding value in clinical decision-making in this complex scenario. Full article

VE is a powerful technique for analyzing a design with a focus on functionality, reducing costs, and increasing value. However, in order to proceed with the design of VE, the theoretical basis for the VE target selection process, which must be preceded in the preparation stage, is lacking, and as a result, it is difficult to verify the most effective target selection. Thus, a theoretical basis is needed. In this study, we intend to quantify the “Worth” value of the “Cost to Worth” technique and present an objective model of the target selection method using the derived value index (VI). For this purpose, cost worth (Worth C) was calculated based on the performance data of 1008 cases for 15 building types provided by the Domestic Public Procurement Service and the share of 83 detailed processes in seven fields. Then, a survey was conducted targeting the ordering companies, and the final worth (Worth F) was calculated by multiplying the derived customer value (Worth V) weight for each detailed work type. We calculated the value index (VI) by comparing “Cost” and “Worth F” for each detailed construction type of the VE project and developed a model to select construction types that exceed the VI standard value derived using the standard error of the population. Both cost experts and non-cost experts can use the developed model to specify the VE target selection criteria in order to easily select the key target, objectively sort the values that serve as the basis for calculating the value index, and make it possible to more easily select the VE target selection criteria based on theoretical evidence. Also, the model can be used to obtain effective detailed design VE results. Full article

Intelligent compaction (IC) has emerged as a breakthrough technology that utilizes advanced sensing, data transmission, and control systems to optimize asphalt pavement compaction quality and efficiency. However, accurate assessment of compaction status remains challenging under real construction conditions. This paper reviewed recent progress and applications of smart sensors and machine learning (ML) to address existing limitations in IC. The principles and components of various advanced sensors deployed in IC systems were introduced, including SmartRock, fiber Bragg grating, and integrated circuit piezoelectric acceleration sensors. Case studies on utilizing these sensors for particle behavior monitoring, strain measurement, and impact data collection were reviewed. Meanwhile, common ML algorithms including regression, classification, clustering, and artificial neural networks were discussed. Practical examples of applying ML to estimate mechanical properties, evaluate overall compaction quality, and predict soil firmness through supervised and unsupervised models were examined. Results indicated smart sensors have enhanced compaction monitoring capabilities but require robustness improvements. ML provides a data-driven approach to complement traditional empirical methods but necessitates extensive field validation. Potential integration with digital construction technologies such as building information modeling and augmented reality was also explored. In conclusion, leveraging emerging sensing and artificial intelligence presents opportunities to optimize the IC process and address key challenges. However, cooperation across disciplines will be vital to test and refine technologies under real-world conditions. This study serves to advance understanding and highlight priority areas for future research toward the realization of IC’s full potential. Full article

Bamboo is a naturally occurring composite material, which exhibits a decomposable structure with varying composition. The distinct structural features of bamboo contribute to its exceptional strength and flexibility, making it an excellent choice for construction purposes. However, only a limited portion of bamboo species has been studied for its mechanical properties, and research on Bambusa arundinaceae has primarily focused on its pharmaceutical values. Therefore, we investigated the relationship between the structural characteristics of B. arundinaceae and its mechanical properties using axial compression experiments and tangential bending experiments. The results showed that the distribution density of vascular bundles (VBs) of B. arundinaceae ranged from 1.98 to 4.34 pcs/mm²,while the volume fraction of fiber sheaths (FSs) ranged from 35.82 to 42.58%. The average compressive strength, flexural strength, and flexural elasticity modulus were 113.99 MPa, 239.07 MPa, and 17.39 GPa, which were 97.56%, 64.07%, and 66.09% higher than those of moso bamboo (Phyllostachys edulis), respectively. The compressive strength, flexural strengths, and elasticity modulus of B. arundinaceae were positively correlated with both the distribution density of VBs and the volume fraction of FSs. These insights are crucial for the advancement of durable and efficient materials in diverse sectors including construction and manufacturing. Full article

In recent years, with advancements in nanotechnology and materials science, new enzyme immobilization strategies based on nanomaterials have continuously emerged. These strategies have shown significant effects on enhancing enzyme catalytic performance and stability due to their high surface area, good chemical stability, and ease of enzyme binding, demonstrating tremendous potential for industrial applications. Those methods that can rapidly synthesize nanocarriers under mild conditions allow for the one-step synthesis of nanocarriers and enzyme complexes, thereby exhibiting advantages such as simplicity of process, minimal enzyme damage, short processing times, and environmental friendliness. This paper provides an overview of simultaneous enzyme immobilization strategies accompanied by nanocarrier synthesis, including organic–inorganic hybrid nano-flowers (HNFs), metal–organic frameworks (MOFs), and conductive polymers (CPs). It covers their preparation principles, post-immobilization performance, applications, and existing challenges. Full article

In this paper, a thorough investigation is presented on the static and dynamic behaviors of a short-span cable-stayed bridge (CSB) incorporating steel and carbon fiber reinforced polymer (CFRP) hybrid cables. The study focuses on the world’s largest span and China’s first highway, CFRP CSB. The performance of the CSB was compared using numerical simulations under four different cable patterns: steel cables, CFRP cables, and steel, and two types of hybrid cables with different structural arrangements. The results indicate that the use of the use of CFRP cables in the long cable region in the short-span CSB project investigated in this study offers improved performance in terms of stability, seismic response, and reduced displacements. In comparison to CFRP cables, hybrid cables have demonstrated a reduction of 12% in the maximum vertical displacement of the main girder. On the other hand, the hybrid cables result in reduced maximum internal forces and longitudinal and lateral displacements of the main girders and towers compared to steel cables. The difference in the arrangement of CFRP cables in the long cable region or short cable region is not obvious under dead loads, but significant differences still exist between the CFRP cable bridges in the short cable region and the long cable region in terms of live load effects, temperature effects, and dynamic characteristics. Full article

 Background and Objectives: This retrospective cohort study analyzes mechanical complications in hip fracture surgery using the Trochanteric Fixation Nail-Advanced (TFNA) implant. It investigates the correlation of these complications with demographic, intraoperative, and radiological factors, aiming to identify associated risk factors and suggest improvements in clinical surveillance and treatment strategies. Materials and Methods: We enrolled 253 patients diagnosed with pertrochanteric hip fractures treated between 2017 and 2021, with 126 meeting the criteria for a minimum 6-month follow-up. Data on demographics, American Anesthesia Association Classification (ASA), comorbidities, AO/OTA [AO (Arbeitsgemeinschaft für Osteosynthesefragen)/OTA (Orthopedic Trauma Association)] fracture classification, procedural details, and time to failure were collected. Radiographs were evaluated for reduction quality, the tip–apex distance (TAD), progressive varus deviation, and identification of mechanical complications. Statistical analysis was performed using SPSS software. Results: The predominant AO/OTA fracture classification was 31A2 in 67 cases (52.7%). Reduction quality was deemed good or acceptable in 123 cases (97.6%). The mean time to failure was 4.5 months (range: 2.2–6). The average TAD was 18 mm (range: 1.2–36), with a mean progressive varus deviation of 2.44° (range: 1.30–4.14). A good or acceptable reduction quality was observed in 97.6% of cases. Mechanical complications occurred in 21.4% of patients, with significant associations found with the lateral cortex fracture, use of a TFNA implant with a 130° angle, open reduction, and absence of prior osteoporosis treatment. Conclusions: The study provides insights into mechanical complications in proximal femur fractures treated with the TFNA nail, emphasizing the need for enhanced clinical and radiographic surveillance, especially in patients without osteoporosis treatment. Our findings support the necessity for further clinical studies comparing these outcomes with other implant designs and underscore the importance of personalized treatment strategies to reduce complication rates.  Full article