Antidepressants are among the most used medications in the US, with significant deleterious effects on people’s well-being. At any given time, depression impacts approximately 1 in 10 Americans, causing wide and broad societal costs. Interest is developing for non-pharmacological treatments and preventative measures. We summarize the literature on non-invasive dietary and lifestyle approaches for treating depression. This review aims to inform future research and treatment programs for depression by providing an evidentiary summary of integrative therapeutic approaches for depression. Full article

Binary Code Similarity Detection is a method that involves comparing two or more binary code segments to identify their similarities and differences. This technique plays a crucial role in areas such as software security, vulnerability detection, and software composition analysis. With the extensive use of binary code in software development and system optimization, binary code similarity detection has become an important area of research. Traditional methods of source code similarity detection face challenges when dealing with the unreadable and complex nature of binary code, necessitating specialized techniques and algorithms. This review compares and summarizes various techniques and methods of binary code similarity detection, highlighting their strengths and limitations in handling different characteristics of binary code. Additionally, the article suggests potential future research directions. As research and innovation in this technology continue to advance, binary code similarity detection is expected to play an increasingly significant role in fields like software security. Full article

Genetic studies preceded by the observation of an unknown mosquito species in Mikołów (Poland) confirmed that it belongs to a new invasive species in Polish fauna, Aedes japonicus (Theobald, 1901), a known vector for numerous infectious diseases. Ae. japonicus is expanding its geographical presence, raising concerns about potential disease transmission given its vector competence for chikungunya virus, dengue virus, West Nile virus, and Zika virus. This first genetically confirmed identification of Ae. japonicus in Poland initiates a comprehensive review of the literature on Ae. japonicus, its biology and ecology, and the viral infections transmitted by this species. This paper also presents the circumstances of the observation of Ae. japonicus in Poland and a methodology for identifying this species. Full article

The available evidence on vitamin K status in cystic fibrosis (CF) is scarce, lacking data on vitamin K2 (menaquinones—MK). Therefore, we assessed vitamin K1, MK-4 and MK-7 concentrations (LC-MS/MS) in 63 pancreatic insufficient and modulator naïve CF patients, and compared to 61 healthy subjects (HS). Vitamin K1 levels did not differ between studied groups. MK-4 concentrations were higher (median <1st–3rd quartile>: 0.778 <0.589–1.086> vs. 0.349 <0.256–0.469>, p < 0.0001) and MK-7 levels lower (0.150 <0.094–0.259> vs. 0.231 <0.191–0.315>, p = 0.0007) in CF patients than in HS. MK-7 concentrations were higher in CF patients receiving K1 and MK-7 supplementation than in those receiving vitamin K1 alone or no supplementation. Moreover, vitamin K1 concentrations depended on the supplementation regime. Based on multivariate logistic regression analysis, we have found that MK-7 supplementation dose has been the only predictive factor for MK-7 levels. In conclusion, vitamin K1 levels in CF are low if not currently supplemented. MK-4 concentrations in CF patients supplemented with large doses of vitamin K1 are higher than in HS. MK-7 levels in CF subjects not receiving MK-7 supplementation, with no regard to vitamin K1 supplementation, are low. There do not seem to be any good clinical predictive factors for vitamin K status. Full article

Convoys composed of autonomous vehicles could improve the transportation and freight industries in several ways. One of the avenues of improvement is in fuel efficiency, where the vehicles maintain a close following distance to each other in order to reduce air resistance by way of the draft effect. While close following distances improve fuel efficiency, they also reduce both the margin of safety and the system’s tolerance to disturbances in relative position. The system’s tolerance to disturbances is known as string stability, where the error magnitude either grows or decays as it propagates rearward through the convoy. One of the major factors in a system’s string stability is its delay in sending state updates to other vehicles, the most pertinent being a hard braking maneuver. Both external sensors and vehicle-to-vehicle communication standards have relatively long delays between peer vehicle state changes and the information being actionable by the ego vehicle. The system presented here, called the Convoy Vehicular Ad Hoc Network (Convoy VANET), was designed to reliably propagate emergency event messages with low delay while maintaining reasonable channel efficiency. It accomplishes this using a combination of several techniques, notably relative position-based retransmission delays. Our results using Network Simulator 3 (ns3) show the system propagating messages down a 20-vehicle convoy in less than 100 ms even with more than a 35% message loss between vehicles that are not immediately adjacent. These simulation results show the potential for this kind of system in situations where emergency information must be disseminated quickly in low-reliability wireless environments. Full article

Titanium continues to be the gold standard in the field of osteosynthesis materials. This also applies to pediatric craniofacial surgery. Various resorbable materials have already been developed in order to avoid costly and risky second operations to remove metal in children. However, none of these resorbable materials have been able to completely replace the previous gold standard, titanium, in a satisfactory manner. This has led to the need for a new resorbable osteosynthesis material that fulfills the requirements for biocompatibility, stability, and uniform resorption. In our previous in vitro and in vivo work, we were able to show that molybdenum fulfills these requirements. To further confirm these results, we conducted a proof of concept in four domestic pigs, each of which was implanted with a resorbable molybdenum implant. The animals were then examined daily for local inflammatory parameters. After 54 days, the animals were euthanized with subsequent computer tomography imaging. We also removed the implants together with the surrounding tissue and parts of the spleen, liver, and kidney for histopathological evaluation. The molybdenum implants were also analyzed metallographically and using scanning electron microscopy. A blood sample was taken pre- and post-operatively. None of the animals showed clinical signs of inflammation over the entire test period. Histopathologically, good tissue compatibility was found. Early signs of degradation were observed after 54 days, which were not sufficient for major resorption. Resorption is expected with longer in situ residence times based on results of similar earlier investigations. Full article

Computational simulations of three-dimensional flow around a NACA 0018 wing with an aspect ratio of $AR=5$ were carried out by using the Unsteady Reynolds-Averaged Navier–Stokes (URANS) equations with the Shear-Stress Transport turbulence model closure. Simulations were performed to capture aerodynamic stall hysteresis by using the developed pseudo-transient continuation (PTC) method based on a dual-time step approach in CFD OpenFOAM code. The flow was characterized by incompressible Mach number $M=0.12$ and moderate Reynolds number $Re=0.67\times {10}^6$. The results obtained indicate the presence of noticeable aerodynamic hysteresis in the static dependencies of the force and moment coefficients, as well as the manifestation of bi-stable flow separation patterns, accompanied by the development of asymmetry in the stall zone. The URANS simulation results are in good agreement with the experimental data obtained for the NACA 0018 finite-aspect-ratio wing in the low-speed wind tunnel under the same test conditions. A new phenomenological bifurcation model of aerodynamic stall hysteresis under static and dynamic conditions is formulated and is proven to be able to closely match the experimental data. Full article

The human gut microbiota, an intricate ecosystem within the gastrointestinal tract, plays a pivotal role in health and disease. Prebiotics, non-digestible food ingredients that beneficially affect the host by selectively stimulating the growth and/or activity of beneficial microorganisms, have emerged as a key modulator of this complex microbial community. This review article explores the evolution of the prebiotic concept, delineates various types of prebiotics, including fructans, galactooligosaccharides, xylooligosaccharides, chitooligosaccharides, lactulose, resistant starch, and polyphenols, and elucidates their impact on the gut microbiota composition. We delve into the mechanisms through which prebiotics exert their effects, particularly focusing on producing short-chain fatty acids and modulating the gut microbiota towards a health-promoting composition. The implications of prebiotics on human health are extensively reviewed, focusing on conditions such as obesity, inflammatory bowel disease, immune function, and mental health. The review further discusses the emerging concept of synbiotics—combinations of prebiotics and probiotics that synergistically enhance gut health—and highlights the market potential of prebiotics in response to a growing demand for functional foods. By consolidating current knowledge and identifying areas for future research, this review aims to enhance understanding of prebiotics’ role in health and disease, underscoring their importance in maintaining a healthy gut microbiome and overall well-being. Full article

A sensorless vector active disturbance rejection control (ADRC) method for permanent magnet synchronous motors (PMSM) utilizing a Luenberger observer is presented. This method aims to address the challenges associated with weak active disturbances, substantial steady-state speed amplitude fluctuations, and difficulty in achieving a balance between overshoot and speed control in the sensorless PMSM control system. Mathematical models of the Luenberger observer and the ADRC were analyzed, leading to the proposal of a second-order ADRC control method based on the Luenberger observer. A mathematical model of the permanent PMSM has been introduced. Additionally, the necessary conditions for the convergence of the Luenberger observer were derived and examined. The allowable range of error feedback gain values was determined, and rotor position data were acquired using a phase-locked loop. The principle of the ADRC was analyzed, and the ADRC simulation results, along with the PI simulation results, were detailed. When the target speed is 1000 r/min, the steady-state error and load disturbance resistance of the ADRC control method outperform those of the PI control method. Finally, the control method was experimentally tested on an STM32F4 chip, demonstrating the advantages of small steady-state error and strong active disturbance ability. Full article

Anthocyanin accumulation is regulated by specific genes during fruit ripening. Currently, peel coloration of mango fruit in response to exogenous ethylene and the underlying molecular mechanism remain largely unknown. The role of MiMYB8 on suppressing peel coloration in postharvest ‘Guifei’ mango was investigated by physiology detection, RNA-seq, qRT-PCR, bioinformatics analysis, yeast one-hybrid, dual-luciferase reporter assay, and transient overexpression. Results showed that compared with the control, low concentration of exogenous ethylene (ETH, 500 mg·L⁻¹) significantly promoted peel coloration of mango fruit (cv. Guifei). However, a higher concentration of ETH (1000 mg·L⁻¹) suppressed color transformation, which is associated with higher chlorophyll content, lower a* value, anthocyanin content, and phenylalanine ammonia-lyase (PAL) activity of mango fruit. M. indica myeloblastosis8 MiMYB8 and MiPAL1 were differentially expressed during storage. MiMYB8 was highly similar to those found in other plant species related to anthocyanin biosynthesis and was located in the nucleus. MiMYB8 suppressed the transcription of MiPAL1 by binding directly to its promoter. Transient overexpression of MiMYB8 in tobacco leaves and mango fruit inhibited anthocyanin accumulation by decreasing PAL activity and down-regulating the gene expression. Our observations suggest that MiMYB8 may act as repressor of anthocyanin synthesis by negatively modulating the MiPAL gene during ripening of mango fruit, which provides us with a theoretical basis for the scientific use of exogenous ethylene in practice. Full article

The seafood processing industry generates significant waste, including mackerel heads (MH), constituting 20–32% of total waste. This study explored the potential of utilizing MH as a feed source for black soldier fly larvae (BSF larvae). BSF larvae are known for their ability to efficiently convert organic materials into nutrient-rich biomass. Five concentrations of MH (0, 10, 20, 30, 40, and 50% in chicken feed) were fed to BSF larvae for eight days. After harvesting, their growth, MH conversion efficiency, nutritional content, and heavy metals reduction potential were measured. BSF larvae showed optimal growth when fed with a feed containing 20% MH, resulting in a 14.36-fold increase in weight compared to the control group, as determined by the Fisher’s Least Significant Difference Test. BSF larvae maintained a survival rate of 99.33%. With the lowest feed conversion ratio (FCR) of 2.09 at 20% MH, feed efficiency was improved by up to 65.15%, and feed reduction up to 73.53%. MH enhanced lipid and protein content in BSF larvae. Furthermore, BSF larvae in this study showed higher polyunsaturated fatty acids (PUFA), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), as well as other amino acids which are required for breeding animals. The current study highlights the potential of MH as a feed source for BSF larvae, improving nutritional biomass. It also suggests BSF larvae as an eco-friendly option for handling seafood processing waste and as an alternative feed source for animals. Full article

Research on endophytic fungi in desert plants, particularly the epiphytic or endophytic fungi of leaves, remains limited. In the extremely arid regions of northwest China, the ultra-xerophytic desert plant Haloxylon ammodendron harbors white fungi on its assimilating branches during autumn. The hyphae of these fungi intertwine, both internally and externally, comprising superficial, bridging, and endophytic types. The superficial hyphae attach to the surface of the assimilating branches and continuously grow and intersect, forming a thick layer of felt-like hyphae. This thick, felt-like layer of hyphae facilitates the adsorption of atmospheric water vapor on the surface of the hyphae or the assimilating branches, allowing H. ammodendron to capture atmospheric moisture, even under low humidity. Some superficial hyphae penetrate the cuticle into the epidermis, becoming bridging hyphae, which can rapidly transport water from the outside of the epidermis to the inside. The endophytic hyphae shuttle within the epidermis, achieving rapid water transfer within the epidermis of the assimilating branches. The presence of these three types of hyphae not only enables the assimilating branches of H. ammodendron to achieve rapid water absorption and transmission, but also facilitates the uptake of atmospheric water vapor under low humidity conditions. We discuss the mechanism by which the hyphae promote water absorption from the perspectives of hyphal composition, the formation of felt-like structures, and environmental conditions. We consider the presence of fungal hyphae on the surface of the H. ammodendron assimilating branches as an inevitable ecological process in arid environments. This study provides important theoretical insights into the mechanisms underlying the strong drought resistance of desert plants in extremely arid regions and offers strategies for desertification control. Full article

Obtaining accurate and real-time spatial distribution information regarding crops is critical for enabling effective smart agricultural management. In this study, innovative decision fusion strategies, including Enhanced Overall Accuracy Index (E-OAI) voting and the Overall Accuracy Index-based Majority Voting (OAI-MV), were introduced to optimize the use of diverse remote sensing data and various classifiers, thereby improving the accuracy of crop/vegetation identification. These strategies were utilized to integrate crop/vegetation classification outcomes from distinct feature sets (including Gaofen-6 reflectance, Sentinel-2 time series of vegetation indices, Sentinel-2 time series of biophysical variables, Sentinel-1 time series of backscatter coefficients, and their combinations) using distinct classifiers (Random Forests (RFs), Support Vector Machines (SVMs), Maximum Likelihood (ML), and U-Net), taking two grain-producing areas (Site #1 and Site #2) in Haixi Prefecture, Qinghai Province, China, as the research area. The results indicate that employing U-Net on feature-combined sets yielded the highest overall accuracy (OA) of 81.23% and 91.49% for Site #1 and Site #2, respectively, in the single classifier experiments. The E-OAI strategy, compared to the original OAI strategy, boosted the OA by 0.17% to 6.28%. Furthermore, the OAI-MV strategy achieved the highest OA of 86.02% and 95.67% for the respective study sites. This study highlights the distinct strengths of various remote sensing features and classifiers in discerning different crop and vegetation types. Additionally, the proposed OAI-MV and E-OAI strategies effectively harness the benefits of diverse classifiers and multisource remote sensing features, significantly enhancing the accuracy of crop/vegetation classification. Full article

In this study, the response surface method is used to develop a model for analyzing and optimizing zinc leaching experiments. An investigation into the leaching kinetics of smithsonite in ammonium citrate solution is also conducted. A model of kinetics is studied in order to represent these effects. The experimental data show that an increase in the solution temperature, concentration, and stirring speed has a positive impact on the leaching rate, while an increase in the particle size has a negative impact on it. The optimal experimental conditions consist of a leaching temperature of 70 °C, ammonium citrate concentration of 5 mol/L, particle size of 38 µm, and rotational speed of 1000 rpm. Under these optimal conditions, the leaching rate of zinc from smithsonite is 83.51%. It is speculated that the kinetic model will change when the temperature is higher than 60 °C. When the temperature is lower than 60 °C, the leaching process is under the control of the shrinking core model of the surface chemical reactions. The calculated activation energy of the leaching reaction is equal to 42 kJ/mol. The model of the leaching process can be described by the following equation: $1-{\left(1-\left.x\right)\right.}^{1/3}=\left[k_0\right.\cdot {\left(C\right)}^{0.6181}\cdot {\left(r_0\right)}^{-0.5868}\cdot {\left(SS\right)}^{0.6901}\mathit{exp}\left(-42/RT\right)]t$. This demonstrates that an ammonium citrate solution can be used in the leaching process of zinc in smithsonite as an effective and clean leaching agent. Full article

The fruit of Phyllanthus emblica L. (FEPE) has a long history of use in Asian folk medicine. The main bioactive compounds in FEPE are polyphenols, known for their potent antioxidant, anti-inflammatory, and hypolipidemic activities. The present study aimed to investigate the intervention effect of FEPE (100 and 200 mg/kg) on hyperlipidemia for 8 weeks and preliminarily explored the potential mechanism by microbiome-metabolome analysis. The results showed that a high-dose FEPE (200 mg/kg) effectively alleviated dyslipidaemic symptoms and body weight gain in hyperlipidemic mice induced by a high-fat diet (HFD). Microbiome analysis showed that FEPE altered the structure of the intestinal microbiota, which included an increase in specific probiotics (such as Akkermansia, Anaerovorax, and Bacteroides) and a decrease in harmful bacteria (including A2, Acetitomaculum, Candidatus_Arthromitus, Lachnospiraceae_NK4A136_group, Lachnospiraceae_NK4B4_group, Rikenella, and Streptococcus), as well as a reduction in the level of short-chain fatty acids (SCFAs). In addition, significant changes in the hepatic metabolome were observed, and eight key metabolites associated with betaine metabolism, lysine degradation, methionine metabolism, and fatty acid metabolism pathways were primarily filtered. The correlated analysis identified several key “microbiota-metabolite” axes in the treatment of hyperlipidemia by FEPE extract. In conclusion, the present study is expected to provide a basis for treating hyperlipidemia with FEPE from the perspective of the microbiome-liver metabolome axis. Full article

A position identification system for wandering elderly people uses BLE to transmit ID information. The objective of this study is to make the BLE module batteryless using a piezoelectric element. The piezoelectric element is mounted on the sole of a shoe, and when pressure is applied to the piezoelectric element by walking, a voltage is generated between both electrodes of the piezoelectric element. This voltage is used to store the necessary power as a battery to operate the BLE module. In this paper, we provide a step-by-step design approach using piezoelectric elements attached to a shoe to power an actual BLE module. We derive an equivalent circuit for the piezoelectric element under walking conditions and, through circuit simulation and actual measurements, clarify the amount of time required to charge the voltage to drive the BLE, demonstrating the possibility of a batteryless BLE module for use in locating a wanderer while they are walking. Full article

In order to foster a more sustainable and eco-friendly trajectory for the construction industry, while concurrently mitigating environmental pollution and energy inefficiency, it is imperative to cultivate an environmentally conscious building and urban environment. Under the background of Carbon Peak and Carbon Neutrality, the green building rating system has become a research hotspot in the field of green building. This paper systematically summarizes the research progress of the GBRS in weight setting, indicator setting, and the evaluation process, and creatively proposes the following three directions for future research: (1) Weight determination methods based on machine learning or deep learning models, and reasonable weight allocation by mixing multiple evaluation methods. (2) Setting dynamic evaluation indicators, strengthening interdisciplinary research and regional consideration, and introducing a life cycle assessment to solve the problem of setting indicators in the existing evaluation system. (3) Combine building information modeling with GBRS to realize the automation and intelligence of evaluation and improve the comprehensiveness and accuracy of evaluation. Full article

Non-small cell lung cancer (NSCLC) patients are often complicated by other respiratory diseases, including interstitial pneumonia (IP), chronic obstructive pulmonary disease (COPD), and pulmonary tuberculosis (TB), and the management of which can be problematic. NSCLC patients with IP sometimes develop fatal acute exacerbation induced by pharmacotherapy, and the establishment of a safe treatment strategy is desirable. For advanced NSCLC with IP, carboplatin plus nanoparticle albumin-bound paclitaxel is a relatively safe and effective first-line treatment option. Although the safety of immune checkpoint inhibitors (ICIs) for these populations remains controversial, ICIs have the potential to provide long-term survival. The severity of COPD is an important prognostic factor in NSCLC patients. Although COPD complications do not necessarily limit treatment options, it is important to select drugs with fewer side effects on the heart and blood vessels as well as the lungs. Active TB is complicated by 2–5% of NSCLC cases during their disease course. Since pharmacotherapy, especially ICIs, reportedly induces the development of TB, the possibility of developing TB should always be kept in mind during NSCLC treatment. To date, there is no coherent review article on NSCLC with these pulmonary complications. This review article summarizes the current evidence and discusses future prospects for treatment strategies for NSCLC patients complicated with IP, severe COPD, and TB. Full article

Microelectromechanical systems (MEMS) ohmic contact switches are considered to be a promising candidate for wireless communication applications. The longevity of MEMS switches is directly related to the reliability and performance of microcontacts. In this work, an improved microcontact test fixture with high actuation rates (KHz) and highly precise position control (nm) and force (nN) control was developed. Here, we collected microcontact performance data from initial contact tests (ICT) and microcontact reliability data from cold switched tests (CST). To perform these tests with our test fixture, we fabricated MEMS microcontact test structures with relatively high Young’s modulus electroplated Nickel (Ni)-based, fixed–fixed beam structure with Au/RuO₂ bimetallic microcontacts. These structures were characterized for forces ranging from 200–1000 µN in ICT tests. In a CST test, the tested microcontact survived more than 200 million cycles at a 1 KHz cycle rate, with a stable contact resistance value ranging between 3.8–5.2 Ω. These experiments validate the potentiality of our microcontact test fixture, and will facilitate further investigation on advanced microcontacts to enhance the MEMS switch’s reliability. Full article

Information theory explains how systems encode and transmit information. This article examines the neuronal system, which processes information via neurons that react to stimuli and transmit electrical signals. Specifically, we focus on transfer entropy to measure the flow of information between sequences and explore its use in determining effective neuronal connectivity. We analyze the causal relationships between two discrete time series, $\mathit{X}:=\left\{X_t:t\in \mathbb{Z}\right\}$ and $\mathit{Y}:=\left\{Y_t:t\in \mathbb{Z}\right\}$, which take values in binary alphabets. When the bivariate process $(\mathit{X},\mathit{Y})$ is a jointly stationary ergodic variable-length Markov chain with memory no larger than k, we demonstrate that the null hypothesis of the test—no causal influence—requires a zero transfer entropy rate. The plug-in estimator for this function is identified with the test statistic of the log-likelihood ratios. Since under the null hypothesis, this estimator follows an asymptotic chi-squared distribution, it facilitates the calculation of p-values when applied to empirical data. The efficacy of the hypothesis test is illustrated with data simulated from a neuronal network model, characterized by stochastic neurons with variable-length memory. The test results identify biologically relevant information, validating the underlying theory and highlighting the applicability of the method in understanding effective connectivity between neurons. Full article

There is a growing interest in exploring new natural sources of colorants. This study aimed to extract anthocyanins from broken black bean hulls (Phaseolus vulgaris L.) by modifying water with a eutectic mixture (choline chloride:citric acid (ChCl:Ca)). Ultrasound-assisted extraction (UAE) was employed and optimized in terms of temperature (30–70 °C), ultrasound power (150–450 W), and eutectic mixture concentration in water (1–9% (w/v)), resulting in an optimal condition of 66 °C, 420 W, and 8.2% (w/v), respectively. The main quantified anthocyanins were delphinidin-3-O-glycoside, petunidin-3-O-glycoside, and malvidin-3-O-glycoside. The half-life of the anthocyanins at 60 °C increased twelvefold in the eutectic mixture extract compared to the control, and when exposed to light, the half-life was 10 times longer, indicating greater resistance of anthocyanins in the extracted eutectic mixture. Additionally, the extracts were concentrated through centrifuge-assisted cryoconcentration, with the initial cycle almost double the extract value, making this result more favorable regarding green metrics. The first concentration cycle, which showed vibrant colors of anthocyanins, was selected to analyze the color change at different pH levels. In general, the technology that uses eutectic mixtures as water modifiers followed by cryoconcentration proved to be efficient for use as indicators in packaging, both in quantity and quality of anthocyanins. Full article

High-performance Cu catalysts were developed for the selective hydrogenation of γ-butyrolactone (GBL) to 1,4-butanediol (BDO). Among the various catalysts prepared by ammonia evaporation (AE) and impregnation (IM) methods with silica or MFI zeolite supports, the 5% Cu-SiO₂-AE catalyst was the best one. It exhibited 95% selectivity for BDO and 71% conversion of GBL after 2–8 h reaction at 200 °C and 4 MPa H_2, with high stability in five-cycle runs. Comprehensive characterizations showed that the AE method favored generating nano Cu particles with an average size of 2.9 nm on the 5% Cu-SiO₂-AE catalyst. The silica support derived from a sol demonstrated an advantage over the MFI zeolite in the preparation of a highly dispersed and stable Cu catalyst, in view of its anti-sintering and robust composition of Cu⁰, Cu⁺, and Cu²⁺ in the cycling operation. The reaction pathways for GBL to BDO over the Cu catalysts were found to commonly involve reversible reactions of hydrogenation and dehydrogenation, along with subsequent dehydration to form THF. The high performance of the Cu catalysts in the conversion of GBL to BDO was attributed to the high dispersion of Cu, the presence of stable active sites, and fewer strong acid sites in the catalyst. Full article