The 2023 MDPI Annual Report has
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13 pages, 256 KiB  
Article
Informed Ignorance as a Form of Epistemic Injustice
by Noa Cohen and Mirko Daniel Garasic
Philosophies 2024, 9(3), 59; https://doi.org/10.3390/philosophies9030059 (registering DOI) - 29 Apr 2024
Abstract
Ignorance, or the lack of knowledge, appears to be steadily spreading, despite the increasing availability of information. The notion of informed ignorance herein proposed to describe the widespread position of being exposed to an abundance of information yet lacking relevant knowledge, which is [...] Read more.
Ignorance, or the lack of knowledge, appears to be steadily spreading, despite the increasing availability of information. The notion of informed ignorance herein proposed to describe the widespread position of being exposed to an abundance of information yet lacking relevant knowledge, which is tied to the exponential growth in misinformation driven by technological developments and social media. Linked to many of societies’ most looming catastrophes, from political polarization to the climate crisis, practices related to knowledge and information are deemed some of the most imminent and daunting modern threats, evidenced by the latest report of the World Economic Forum, which has named misinformation the most severe short-term global risk. This paper’s epistemic perspective links the properties of today’s information culture and the ways in which it interacts with individual capacities and limitations in current technological and socio-political contexts. Such a position is analyzed through the lens of epistemic principles as a contemporary epistemic phenotype that emerges from an environment of ill-adapted and excessive information inputs and leads to a distinctive type of social injustice that is primarily epistemic in nature. While equity and accessibility are widely discussed as important contributing factors to epistemic discrepancies, other overlooked but fundamental issues underlying epistemic injustices are considered, such as information manipulation, cognitive limitations, and epistemic degradation. To effectively face this elusive threat, we propose an inclusive viewpoint that harnesses knowledge from cognitive science, science and technology studies, and social epistemology to inform a unifying theory of its main impacts and driving forces. By adjusting a modern epistemic framework to the described phenomena, we intend to contextually outline its trajectory and possible means of containment based on a shared responsibility to maintain ethical epistemic standards. In a time of international unrest and mounting civil acts of violence, it is pertinent to emphasize the ethical principles of knowledge systems and authorities and suggest policy adaptations to maintain a social contract based on the shared values of truth and freedom. Full article
11 pages, 4484 KiB  
Article
Extended Interportal Capsulotomy for Hip Arthroscopy, a Single-Center Clinical Experience
by Ahmet Fırat, Enejd Veizi, Christos Koutserimpas, Hilmi Alkan, Ali Şahin, Şahan Güven and Yasin Erdoğan
Medicina 2024, 60(5), 738; https://doi.org/10.3390/medicina60050738 (registering DOI) - 29 Apr 2024
Abstract
Background and Objectives: The number of hip arthroscopy procedures is on the rise worldwide, and awareness regarding proper management of the hip capsule has increased. No capsulotomy shape is agreed upon as a standard approach, with literature supporting both isolated interportal and [...] Read more.
Background and Objectives: The number of hip arthroscopy procedures is on the rise worldwide, and awareness regarding proper management of the hip capsule has increased. No capsulotomy shape is agreed upon as a standard approach, with literature supporting both isolated interportal and T-shaped capsulotomies. The aim of this retrospective cohort study is to report the clinical results of a standardized extended interportal capsulotomy (EIPC) during hip arthroscopy. Materials and Methods: Patients operated on between 2017 and 2020 with a hip arthroscopy were eligible. The inclusion criteria were ages 18–60 years, failed non-operative treatment, and at least a 2-year follow-up. Exclusion criteria were bilateral femoroacetabular impingement syndrome (FAS) cases or labral lesions, ipsilateral knee injury, history of ipsilateral hip surgery, and significant spine lesions. Data regarding demographic characteristics such as age, gender, operation date, BMI, but also Beighton score, presence of postoperative pudendal nerve damage, and revision for any reason were gathered from patients’ records. All patients were evaluated preoperatively with a visual analog scale (VAS), the Hip Disability and Osteoarthritis Outcome Score (HOOS), and the modified Harris Hip Score (mHHS). Results: Of the 97 patients operated on with a hip arthroscopy between the defined dates, only 90 patients were included. The mean age was 37.9 ± 9.8, and 58.9% of patients were male. The most frequent surgical indication was an isolated FAS lesion (73.3%), followed by FAS associated with a labral tear (12.2%), an isolated labrum tear (10.0%), synovitis (3.3%), and a loose body (1.1%). The mean follow-up for the study cohort was 39.3 months. The majority of the patients had uneventful surgeries (76.7%), while there were three cases of sciatic nerve neuropraxia and 12 cases of pudendal nerve neuropraxia. Two patients underwent revision surgery during the study period. Comparison between preoperative and postoperative clinical scores showed a significant improvement with a final mHHS mean value of 67.7 ± 18.2, an HOOS value of 74.1 ± 13.2, and a low VAS score of 1.3 ± 1.2. Conclusions: A hip arthroscopy procedure with a standardized and unrepaired, extended interportal capsulotomy is a safe procedure with satisfactory mid-term results and high overall patient satisfaction. At a minimum of 2 years and a mean of 39.2 months, patients showed improved clinical scores and a low revision rate. Full article
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17 pages, 1166 KiB  
Article
Resource Allocation and Pricing in Energy Harvesting Serverless Computing Internet of Things Networks
by Yunqi Li and Changlin Yang
Information 2024, 15(5), 250; https://doi.org/10.3390/info15050250 (registering DOI) - 29 Apr 2024
Abstract
This paper considers a resource allocation problem involving servers and mobile users (MUs) operating in a serverless edge computing (SEC)-enabled Internet of Things (IoT) network. Each MU has a fixed budget, and each server is powered by the grid and has energy harvesting [...] Read more.
This paper considers a resource allocation problem involving servers and mobile users (MUs) operating in a serverless edge computing (SEC)-enabled Internet of Things (IoT) network. Each MU has a fixed budget, and each server is powered by the grid and has energy harvesting (EH) capability. Our objective is to maximize the revenue of the operator that operates the said servers and the number of resources purchased by the MUs. We propose a Stackelberg game approach, where servers and MUs act as leaders and followers, respectively. We prove the existence of a Stackelberg game equilibrium and develop an iterative algorithm to determine the final game equilibrium price. Simulation results show that the proposed scheme is efficient in terms of the SEC’s profit and MU’s demand. Moreover, both MUs and SECs gain benefits from renewable energy. Full article
(This article belongs to the Special Issue Internet of Things and Cloud-Fog-Edge Computing)
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18 pages, 1992 KiB  
Article
Resilience of Terraced Landscapes to Human and Natural Impacts: A GIS-Based Reconstruction of Land Use Evolution in a Mediterranean Mountain Valley
by Titouan Le Vot, Marianne Cohen, Maciej Nowak, Paul Passy and Franck Sumera
Land 2024, 13(5), 592; https://doi.org/10.3390/land13050592 (registering DOI) - 29 Apr 2024
Abstract
Terraced historical landscapes have multiple functions in mountain land, limiting erosion, enabling agricultural production and constituting cultural heritage. Currently, they are largely abandoned in Mediterranean regions and facing the ongoing impacts of climate change. Our aim is to reconstruct the evolution of land [...] Read more.
Terraced historical landscapes have multiple functions in mountain land, limiting erosion, enabling agricultural production and constituting cultural heritage. Currently, they are largely abandoned in Mediterranean regions and facing the ongoing impacts of climate change. Our aim is to reconstruct the evolution of land use on the terraces in order to test the hypothesis of the resilience of these landscapes and their age in recent history (17th–21st century). To achieve this, we used various current and archive spatial datasets and GIS knowledge to detect and map terraces and the changes in land use. We tested this hypothesis in a territory impacted by a recent extreme event, facing the challenge of its reconstruction. Our main outcome showed that the optimal use of the terraces corresponded to the demographic optimum of the mid-19th century, and they were gradually abandoned after the Second World War, with significant differences between Mediterranean and mountain lands. Despite this evolution, the terraces persisted and withstood an extreme event, validating our resilience hypothesis and opening avenues for the revitalization of this territory based on this heritage. These findings are drawing perspectives for the future of terraced landscapes in Mediterranean mountains in the context of climate change. Full article
(This article belongs to the Special Issue Resilience in Historical Landscapes)
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18 pages, 6800 KiB  
Article
Sensitivity of Runoff to Climatic Factors and the Attribution of Runoff Variation in the Upper Shule River, North-West China
by Ling Jia, Zuirong Niu, Rui Zhang and Yali Ma
Water 2024, 16(9), 1272; https://doi.org/10.3390/w16091272 (registering DOI) - 29 Apr 2024
Abstract
Climate change and human activities exert significant impact on the mechanism of runoff generation and confluence. Comprehending the reasons of runoff change is crucial for the sustainable development of water resources. Taking the Upper Shule River as the research area, the M-K test [...] Read more.
Climate change and human activities exert significant impact on the mechanism of runoff generation and confluence. Comprehending the reasons of runoff change is crucial for the sustainable development of water resources. Taking the Upper Shule River as the research area, the M-K test and the moving t test were used to diagnose the runoff mutation time. Furthermore, the slope changing ratio of cumulative quantity method (SCRCQ), climate elasticity method, and Budyko equation were utilized to quantitatively evaluate the impacts and contribution rates of climate change and human activities. The following results were obtained: (1) The Upper Shule River experienced a significant increase in runoff from 1972 to 2021, with 1998 marking the year of abrupt change. (2) The runoff sensitivity showed a downward trend from 1972 to 2021. The main factor affecting the decrease in runoff sensitivity was the characteristic parameters of underlying surface (n), followed by precipitation (P), while the influence of potential evapotranspiration (ET0) was the weakest. (3) The response of runoff changes to runoff sensitivity and influencing factors were 90.32% and 9.68%, respectively. (4) The results of three attribution methods indicated that climate change was the primary factor causing the alteration of runoff in the Upper Shule River. The research results supplement the hydrological change mechanisms of the Upper Shule River and provide a scientific basis for future water resources management and flood control measures. Full article
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27 pages, 1173 KiB  
Review
Exploring the Immunological Profile in Breast Cancer: Recent Advances in Diagnosis and Prognosis through Circulating Tumor Cells
by Amalia Kotsifaki, Sousanna Maroulaki and Athanasios Armakolas
Int. J. Mol. Sci. 2024, 25(9), 4832; https://doi.org/10.3390/ijms25094832 (registering DOI) - 29 Apr 2024
Abstract
This review offers a comprehensive exploration of the intricate immunological landscape of breast cancer (BC), focusing on recent advances in diagnosis and prognosis through the analysis of circulating tumor cells (CTCs). Positioned within the broader context of BC research, it underscores the pivotal [...] Read more.
This review offers a comprehensive exploration of the intricate immunological landscape of breast cancer (BC), focusing on recent advances in diagnosis and prognosis through the analysis of circulating tumor cells (CTCs). Positioned within the broader context of BC research, it underscores the pivotal role of the immune system in shaping the disease’s progression. The primary objective of this investigation is to synthesize current knowledge on the immunological aspects of BC, with a particular emphasis on the diagnostic and prognostic potential offered by CTCs. This review adopts a thorough examination of the relevant literature, incorporating recent breakthroughs in the field. The methodology section succinctly outlines the approach, with a specific focus on CTC analysis and its implications for BC diagnosis and prognosis. Through this review, insights into the dynamic interplay between the immune system and BC are highlighted, with a specific emphasis on the role of CTCs in advancing diagnostic methodologies and refining prognostic assessments. Furthermore, this review presents objective and substantiated results, contributing to a deeper understanding of the immunological complexity in BC. In conclusion, this investigation underscores the significance of exploring the immunological profile of BC patients, providing valuable insights into novel advances in diagnosis and prognosis through the utilization of CTCs. The objective presentation of findings emphasizes the crucial role of the immune system in BC dynamics, thereby opening avenues for enhanced clinical management strategies. Full article
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17 pages, 4066 KiB  
Article
Quantitative 3D Analysis of Levator Ani Muscle Subdivisions in Nulliparous Women: MRI Feasibility Study
by Nathalie Moser, Stephan Skawran, Klaus Steigmiller, Barbara Röhrnbauer, Thomas Winklehner, Cäcilia S. Reiner and Cornelia Betschart
Diagnostics 2024, 14(9), 923; https://doi.org/10.3390/diagnostics14090923 (registering DOI) - 29 Apr 2024
Abstract
Background: The levator ani muscle (LAM) is crucial for pelvic floor stability, yet its quantitative MRI assessment is only a recent focus. Our study aims to standardize the quantitative analysis of the LAM morphology within the 3D Pelvic Inclination Correction System (3D-PICS). Methods: [...] Read more.
Background: The levator ani muscle (LAM) is crucial for pelvic floor stability, yet its quantitative MRI assessment is only a recent focus. Our study aims to standardize the quantitative analysis of the LAM morphology within the 3D Pelvic Inclination Correction System (3D-PICS). Methods: We analyzed 35 static MR datasets from nulliparous women examining the pubovisceral (PVM), iliococcygeal (ICM), coccygeal (COC), and puborectal muscle (PRM). The PVM consists of three origin-insertion pairs, namely the puboanal (PAM), puboperineal (PPM) and pubovaginal muscle (PVaM). The analysis included a quantitative examination of the morphology of LAM, focusing on the median location (x/y/z) (x: anterior–posterior, y: superior–inferior, z: left–right) of the origin and insertion points (a), angles (b) and lengths (c) of LAM. Inter-rater reliability was calculated. Results: Interindividual variations in 3D coordinates among muscle subdivisions were shown. In all, 93% of all origin and insertion points were found within an SD of <8 mm. Angles to the xz-plane range between −15.4° (right PRM) and 40.7° (left PAM). The PRM is the largest pelvic muscle in static MRI. The ICC indicated moderate-to-good agreement between raters. Conclusions: The accurate morphometry of the LAM and its subdivisions, along with reliable inter-rater agreement, was demonstrated, enhancing the understanding of normal pelvic anatomy in young nulliparous women. Full article
(This article belongs to the Special Issue Diagnostic Imaging of the Female Pelvis)
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17 pages, 1282 KiB  
Article
Considering Grouped or Individual Non-Methane Volatile Organic Compound Emissions in Life Cycle Assessment of Composting Using Three Life Cycle Impact Assessment Methods
by Ben Joseph and Heinz Stichnothe
Recycling 2024, 9(3), 35; https://doi.org/10.3390/recycling9030035 (registering DOI) - 29 Apr 2024
Abstract
Composting is a waste management practice that converts organic waste into a product that can be used safely and beneficially as a bio-fertiliser and soil amendment. Non-methane volatile organic compounds (NMVOCs) from composting are known to cause damage to human health and the [...] Read more.
Composting is a waste management practice that converts organic waste into a product that can be used safely and beneficially as a bio-fertiliser and soil amendment. Non-methane volatile organic compounds (NMVOCs) from composting are known to cause damage to human health and the environment. The impact of waste management on the environment and workers is recognised as a growing environmental and public health concern. Measurements of NMVOCs emitted during composting have been carried out only in a few studies. NMVOC emissions are typically reported as a group rather than as species or speciation profiles. Recognising the need to investigate the issues associated with NMVOCs, the objective of this study is to estimate variation in life cycle assessment (LCA) results when NMVOCs are considered individual emissions compared to grouped emissions and to compare midpoint and endpoint life cycle impact assessment (LCIA) methods. In general, the ReCiPe 2016 LCIA method estimated the highest impact from the composting process in comparison to IMPACT World+ and EF 3.0 for the impact categories of ozone formation, stratospheric ozone depletion, and particulate matter formation. For ReCiPe 2016 and IMPACT World+, the NMVOC emissions were not linked to human toxicity characterisation factors, meaning that the contribution from NMVOC towards human health risks in and around composting facilities could be underestimated. Using individual NMVOCs helps to additionally estimate the impacts of composting on freshwater ecotoxicity and human carcinogenic and non-carcinogenic toxicity potential. If ecotoxicity or toxicity issues are indicated, then LCA should be accompanied by suitable risk assessment measures for the respective life cycle stage. Full article
(This article belongs to the Special Issue Feature Papers in Recycling 2023)
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14 pages, 1737 KiB  
Article
A Thermodynamic Model for Cryogenic Liquid Hydrogen Fuel Tanks
by Dongkuk Choi, Sooyong Lee and Sangwoo Kim
Appl. Sci. 2024, 14(9), 3786; https://doi.org/10.3390/app14093786 (registering DOI) - 29 Apr 2024
Abstract
Hydrogen is used as a fuel in various fields, such as aviation, space, and automobiles, due to its high specific energy. Hydrogen can be stored as a compressed gas at high pressure and as a liquid at cryogenic temperatures. In order to keep [...] Read more.
Hydrogen is used as a fuel in various fields, such as aviation, space, and automobiles, due to its high specific energy. Hydrogen can be stored as a compressed gas at high pressure and as a liquid at cryogenic temperatures. In order to keep liquid hydrogen at a cryogenic temperature, the tanks for storing liquid hydrogen are required to have insulation to prevent heat leakage. When liquid hydrogen is vaporized by heat inflow, a large pressure is generated inside the tank. Therefore, a technology capable of predicting the tank pressure is required for cryogenic liquid hydrogen tanks. In this study, a thermodynamic model was developed to predict the maximum internal pressure and pressure behavior of cryogenic liquid hydrogen fuel tanks. The developed model considers the heat inflow of the tank due to heat transfer, the phase change from liquid to gas hydrogen, and the fuel consumption rate. To verify the accuracy of the proposed model, it was compared with the analyses and experimental results in the referenced literature, and the model presented good results. A cryogenic liquid hydrogen fuel tank was simulated using the proposed model, and it was confirmed that the storage time, along with conditions such as the fuel filling ratio of liquid hydrogen and the fuel consumption rate, should be considered when designing the fuel tanks. Finally, it was confirmed that the proposed thermodynamic model can be used to sufficiently predict the internal pressure and the pressure behavior of cryogenic liquid hydrogen fuel tanks. Full article
(This article belongs to the Section Mechanical Engineering)
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26 pages, 1704 KiB  
Review
Hypoxia-Inducible Factor-Dependent and Independent Mechanisms Underlying Chemoresistance of Hypoxic Cancer Cells
by Peter Wai Tik Lee, Lina Rochelle Koseki, Takao Haitani, Hiroshi Harada and Minoru Kobayashi
Cancers 2024, 16(9), 1729; https://doi.org/10.3390/cancers16091729 (registering DOI) - 29 Apr 2024
Abstract
In hypoxic regions of malignant solid tumors, cancer cells acquire resistance to conventional therapies, such as chemotherapy and radiotherapy, causing poor prognosis in patients with cancer. It is widely recognized that some of the key genes behind this are hypoxia-inducible transcription factors, e.g., [...] Read more.
In hypoxic regions of malignant solid tumors, cancer cells acquire resistance to conventional therapies, such as chemotherapy and radiotherapy, causing poor prognosis in patients with cancer. It is widely recognized that some of the key genes behind this are hypoxia-inducible transcription factors, e.g., hypoxia-inducible factor 1 (HIF-1). Since HIF-1 activity is suppressed by two representative 2-oxoglutarate-dependent dioxygenases (2-OGDDs), PHDs (prolyl-4-hydroxylases), and FIH-1 (factor inhibiting hypoxia-inducible factor 1), the inactivation of 2-OGDD has been associated with cancer therapy resistance by the activation of HIF-1. Recent studies have also revealed the importance of hypoxia-responsive mechanisms independent of HIF-1 and its isoforms (collectively, HIFs). In this article, we collate the accumulated knowledge of HIF-1-dependent and independent mechanisms responsible for resistance of hypoxic cancer cells to anticancer drugs and briefly discuss the interplay between hypoxia responses, like EMT and UPR, and chemoresistance. In addition, we introduce a novel HIF-independent mechanism, which is epigenetically mediated by an acetylated histone reader protein, ATAD2, which we recently clarified. Full article
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26 pages, 8121 KiB  
Article
Exploring Dynamic Spalling Behavior in Rock–Shotcrete Combinations: A Theoretical and Numerical Investigation
by Lin Luo, Yichao Rui, Jiadong Qiu, Chongjin Li, Xiong Liu and Cong Chen
Mathematics 2024, 12(9), 1346; https://doi.org/10.3390/math12091346 (registering DOI) - 29 Apr 2024
Abstract
Spalling is a widespread dynamic disaster during blasting excavation in underground engineering. To clarify the coupled dynamic response and spalling behavior of an underground tunnel with a spray anchor, an investigation based on the rock–shotcrete combination was conducted using theoretical and numerical methods. [...] Read more.
Spalling is a widespread dynamic disaster during blasting excavation in underground engineering. To clarify the coupled dynamic response and spalling behavior of an underground tunnel with a spray anchor, an investigation based on the rock–shotcrete combination was conducted using theoretical and numerical methods. The mathematical representation of stress wave propagation between rock and shotcrete was deduced based on the elastic stress wave theory. A novel method for predicting the location and time of initial spalling in a rock–shotcrete combination was proposed. A numerical simulation was conducted to verify the validity of the proposed theoretical method. In addition, the effect of the material’s tensile strength, the loading amplitude, and the thickness of shotcrete on the stress evolution and spalling characteristics was studied. The results demonstrate that the initial spalling locations are sensitive to the relationship between the normalized tensile strength of the rock, shotcrete, and interface. A high incident amplitude can cause the initial spalling in rock, and the shotcrete or rock–shotcrete interface can cause initial spalling due to a low incident amplitude. The stress evolution and spalling characteristics are sensitive to the thickness of shotcrete. The location of the initial spalling failure changes with the thickness of the shotcrete. An appropriate increment in thickness and normalized strength of the shotcrete is beneficial to the dynamic stability of underground engineering. Full article
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13 pages, 643 KiB  
Review
The Role of Tele-Exercise for People with Type 2 Diabetes: A Scoping Review
by Hani Fahad A. Albalawi
Healthcare 2024, 12(9), 917; https://doi.org/10.3390/healthcare12090917 (registering DOI) - 29 Apr 2024
Abstract
Background: Supervised exercise interventions tend to be more effective than unsupervised exercises or physical activity advice alone. However, people with type 2 diabetes may find it difficult to attend supervised exercise interventions due to several obstacles. Tele-exercise, or utilizing technology to deliver home-based [...] Read more.
Background: Supervised exercise interventions tend to be more effective than unsupervised exercises or physical activity advice alone. However, people with type 2 diabetes may find it difficult to attend supervised exercise interventions due to several obstacles. Tele-exercise, or utilizing technology to deliver home-based exercise, might be a solution. Objective: This scoping review aimed to explore clinical trials investigating the impact of tele-exercise interventions in individuals with type 2 diabetes Methods: Four electronic databases were searched for the period up to January 2024 for clinical trials investigating the impact of tele-exercise on health-related outcomes in adults with type 2 diabetes. Results: Seven trials involving 460 individuals with type 2 diabetes met the inclusion criteria. In these trials, combined aerobic and resistance exercise programs were the main types delivered remotely. To deliver such programs, both synchronous (n = 4) and asynchronous (n = 3) delivery modes were adopted. Regardless of the delivery mode, all tele-exercise interventions led to improvements in various factors related to type 2 diabetes and its complications, including glycemic control, blood lipids, body composition, functional capacity, muscle strength, and quality of life. The improvements were also found to be as effective as those of supervised exercise. Conclusions: Tele-exercise interventions seem to be feasible and as effective as supervised exercise interventions in terms of improving glycemic control, blood lipids, functional capacity, muscle strength, body composition, and quality of life for people with type 2 diabetes. Full article
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14 pages, 788 KiB  
Article
Analysis of Operated Ankle Fractures in Elderly Patients: Are They All Osteoporotic?
by Giuseppe Rinonapoli, Marco Donantoni, Paolo Ceccarini and Auro Caraffa
Appl. Sci. 2024, 14(9), 3787; https://doi.org/10.3390/app14093787 (registering DOI) - 29 Apr 2024
Abstract
Background: Osteoporosis represents a global problem, which involves high risks of disability and death due to the consequences of fragility fractures. The aim of our study is to verify what type of relationship there is between ankle fractures and osteoporosis. Specifically, we aim [...] Read more.
Background: Osteoporosis represents a global problem, which involves high risks of disability and death due to the consequences of fragility fractures. The aim of our study is to verify what type of relationship there is between ankle fractures and osteoporosis. Specifically, we aim to understand how the clinical and anamnestic characteristics of patients, along with the radiographic features of these fractures, may contribute to considering them as osteoporotic fractures. Methods: The study group includes 51 consecutive patients aged 60 years or older operated for ankle fracture from May to October 2022. The fractures were divided into uni-, bi-, or trimalleolar based on the plain X-rays. All patients underwent femoral and vertebral bone mineralometry by DXA associated with the FRAX questionnaire. Results: Ankle fractures in the elderly were associated with reduced BMD (76.5% of the total patients examined, 83.8% considering only women) and low-energy traumas (82%). Furthermore, these fractures present features of increased complexity as bone mass decreases. Conclusions: Ankle fractures in the elderly exhibit characteristics that suggest a relationship with bone fragility. For these reasons, it might be advisable to initiate a comprehensive fracture risk assessment in elderly patients who experience an ankle fracture. These fractures should not be underrated, and antiresorptive therapy must always be taken into consideration when selecting patients at risk. Full article
(This article belongs to the Section Applied Biosciences and Bioengineering)
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21 pages, 850 KiB  
Article
Reinventing Web Security: An Enhanced Cycle-Consistent Generative Adversarial Network Approach to Intrusion Detection
by Menghao Fang, Yixiang Wang, Liangbin Yang, Haorui Wu, Zilin Yin, Xiang Liu, Zexian Xie and Zixiao Kong
Electronics 2024, 13(9), 1711; https://doi.org/10.3390/electronics13091711 (registering DOI) - 29 Apr 2024
Abstract
Web3.0, as the link between the physical and digital domains, faces increasing security threats due to its inherent complexity and openness. Traditional intrusion detection systems (IDSs) encounter formidable challenges in grappling with the multidimensional and nonlinear traffic data characteristic of the Web3.0 environment. [...] Read more.
Web3.0, as the link between the physical and digital domains, faces increasing security threats due to its inherent complexity and openness. Traditional intrusion detection systems (IDSs) encounter formidable challenges in grappling with the multidimensional and nonlinear traffic data characteristic of the Web3.0 environment. Such challenges include insufficient samples of attack data, inadequate feature extraction, and resultant inaccuracies in model classification. Moreover, the scarcity of certain traffic data available for analysis by IDSs impedes the system’s capacity to document instances of malicious behavior. In response to these exigencies, this paper presents a novel approach to Web3.0 intrusion detection, predicated on the utilization of cycle-consistent generative adversarial networks (CycleGANs). Leveraging the data transformation capabilities of its generator, this method facilitates bidirectional conversion between normal Web3.0 behavioral data and potentially intrusive behavioral data. This transformative process not only augments the diversity and volume of recorded intrusive behaviors but also clandestinely simulates various attack scenarios. Furthermore, through fostering mutual competition and learning between the discriminator and generator, the approach enhances the ability to discern the defining characteristics of potential intrusive behaviors, thereby bolstering the accuracy of intrusion detection. To substantiate the efficacy of the CycleGAN-based intrusion detection method, simulation experiments were conducted utilizing public datasets, including KDD CUP 1999 (KDD), CIC-DDOS2019, CIC-IDS2018, and SR-BH 2020. The experimental findings evince the method’s remarkable accuracies across the four datasets, attaining rates of 99.81%, 97.79%, 89.25%, and 95.15%, respectively, while concurrently maintaining low false-positive rates. This research contributes novel insights and methodologies toward the advancement of Web3.0 intrusion detection through the application of CycleGAN technology, which is poised to play a pivotal role in fortifying the security landscape of Web3.0. Full article
(This article belongs to the Special Issue Applied Cryptography and Practical Cryptoanalysis for Web 3.0)
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17 pages, 4122 KiB  
Systematic Review
FDG-PET in Chimeric Antigen Receptor T-Cell (CAR T-Cell) Therapy Toxicity: A Systematic Review
by Akram Al-Ibraheem, Ahmed Saad Abdlkadir, Egesta Lopci, Sudqi Allouzi, Diana Paez, Maryam Alkuwari, Mohammad Makoseh, Fuad Novruzov, Sharjeel Usmani, Kamal Al-Rabi and Asem Mansour
Cancers 2024, 16(9), 1728; https://doi.org/10.3390/cancers16091728 (registering DOI) - 29 Apr 2024
Abstract
The utilization of chimeric antigen receptor (CAR) T-cell therapy to target cluster of differentiation (CD)19 in cancer immunotherapy has been a recent and significant advancement. Although this approach is highly specific and selective, it is not without complications. Therefore, a systematic review was [...] Read more.
The utilization of chimeric antigen receptor (CAR) T-cell therapy to target cluster of differentiation (CD)19 in cancer immunotherapy has been a recent and significant advancement. Although this approach is highly specific and selective, it is not without complications. Therefore, a systematic review was conducted to assess the current state of positron emission tomography (PET) in evaluating the adverse effects induced by CAR T-cell therapy. A thorough search of relevant articles was performed in databases such as PubMed, Scopus, and Web of Science up until March 2024. Two reviewers independently selected articles and extracted data, which was then organized and categorized using Microsoft Excel. The risk of bias and methodological quality was assessed. In total, 18 articles were examined, involving a total of 753 patients, in this study. A wide range of utilities were analyzed, including predictive, correlative, and diagnostic utilities. While positive outcomes were observed in all the mentioned areas, quantitative analysis of the included studies was hindered by their heterogeneity and use of varying PET-derived parameters. This study offers a pioneering exploration of this promising field, with the goal of encouraging further and more focused research in upcoming clinical trials. Full article
(This article belongs to the Special Issue PET/CT in Tumor Immunotherapy Assessment)
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25 pages, 2357 KiB  
Article
Effectiveness of Company Value Creation Based on Excess Market Value-Added Assessment
by Jarosław Kaczmarek
Sustainability 2024, 16(9), 3711; https://doi.org/10.3390/su16093711 (registering DOI) - 29 Apr 2024
Abstract
This article aims to assess the usefulness of excess market value added to equity as an external measure of company value creation from the perspective of meeting shareholder expectations. This measure compares the expected value as an increase in stock exchange capitalisation in [...] Read more.
This article aims to assess the usefulness of excess market value added to equity as an external measure of company value creation from the perspective of meeting shareholder expectations. This measure compares the expected value as an increase in stock exchange capitalisation in relation to return on equity, equivalent to its cost, decreased by this capital, in relation to the actually achieved level of capitalisation. This paper investigates relations with other external and internal measures. This research is based on measuring value creation in WIG30 Warsaw Stock Exchange companies in 2017–2023. The assessment of the research results was based on mathematical statistics tools, the density measure and the taxonomic measure of similarity. The study tested four hypotheses. The results of this research showed that the excess measure does not distort market information and can be used to assess the effectiveness of shareholder value creation, taking into account shareholder expectations. Secondly, the paper pointed to an unsatisfactory level of value creation in WSE WIG30 companies. The negative assessment of value creation management refers both to effectiveness and efficiency. Thirdly, shareholders continue to use classical financial measures despite the existence of a wide spectrum of value measures. Fourthly, the paper points to the lack of theoretical equality between the market value added (an external measure) and capitalised economic value added (an internal measure). The presented research contributes to unbiased assessments of whether or not shareholder value is simultaneously created and realised in increased share prices (capitalisation) to a higher degree than shareholder expectations. Up to now, no such research studies have been conducted for Polish and foreign capital markets. The research methodology has practical applications in expectations-based management. Full article
(This article belongs to the Special Issue Corporate Finance and Business Administration in Sustainability)
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29 pages, 3947 KiB  
Review
Exploring Immune Redox Modulation in Bacterial Infections: Insights into Thioredoxin-Mediated Interactions and Implications for Understanding Host–Pathogen Dynamics
by Omer M. A. Dagah, Billton Bryson Silaa, Minghui Zhu, Qiu Pan, Linlin Qi, Xinyu Liu, Yuqi Liu, Wenjing Peng, Zakir Ullah, Appolonia F. Yudas, Amir Muhammad, Xianquan Zhang and Jun Lu
Antioxidants 2024, 13(5), 545; https://doi.org/10.3390/antiox13050545 (registering DOI) - 29 Apr 2024
Abstract
Bacterial infections trigger a multifaceted interplay between inflammatory mediators and redox regulation. Recently, accumulating evidence has shown that redox signaling plays a significant role in immune initiation and subsequent immune cell functions. This review addresses the crucial role of the thioredoxin (Trx) system [...] Read more.
Bacterial infections trigger a multifaceted interplay between inflammatory mediators and redox regulation. Recently, accumulating evidence has shown that redox signaling plays a significant role in immune initiation and subsequent immune cell functions. This review addresses the crucial role of the thioredoxin (Trx) system in the initiation of immune reactions and regulation of inflammatory responses during bacterial infections. Downstream signaling pathways in various immune cells involve thiol-dependent redox regulation, highlighting the pivotal roles of thiol redox systems in defense mechanisms. Conversely, the survival and virulence of pathogenic bacteria are enhanced by their ability to counteract oxidative stress and immune attacks. This is achieved through the reduction of oxidized proteins and the modulation of redox-sensitive signaling pathways, which are functions of the Trx system, thereby fortifying bacterial resistance. Moreover, some selenium/sulfur-containing compounds could potentially be developed into targeted therapeutic interventions for pathogenic bacteria. Taken together, the Trx system is a key player in redox regulation during bacterial infection, and contributes to host–pathogen interactions, offering valuable insights for future research and therapeutic development. Full article
(This article belongs to the Section Antioxidant Enzyme Systems)
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27 pages, 8359 KiB  
Review
The Tumor Stroma of Squamous Cell Carcinoma: A Complex Environment That Fuels Cancer Progression
by Alexandra Buruiană, Bogdan-Alexandru Gheban, Ioana-Andreea Gheban-Roșca, Carmen Georgiu, Doința Crișan and Maria Crișan
Cancers 2024, 16(9), 1727; https://doi.org/10.3390/cancers16091727 (registering DOI) - 29 Apr 2024
Abstract
The tumor microenvironment (TME), a complex assembly of cellular and extracellular matrix (ECM) components, plays a crucial role in driving tumor progression, shaping treatment responses, and influencing metastasis. This narrative review focuses on the cutaneous squamous cell carcinoma (cSCC) tumor stroma, highlighting its [...] Read more.
The tumor microenvironment (TME), a complex assembly of cellular and extracellular matrix (ECM) components, plays a crucial role in driving tumor progression, shaping treatment responses, and influencing metastasis. This narrative review focuses on the cutaneous squamous cell carcinoma (cSCC) tumor stroma, highlighting its key constituents and their dynamic contributions. We examine how significant changes within the cSCC ECM—specifically, alterations in fibronectin, hyaluronic acid, laminins, proteoglycans, and collagens—promote cancer progression, metastasis, and drug resistance. The cellular composition of the cSCC TME is also explored, detailing the intricate interplay of cancer-associated fibroblasts (CAFs), mesenchymal stem cells (MSCs), endothelial cells, pericytes, adipocytes, and various immune cell populations. These diverse players modulate tumor development, angiogenesis, and immune responses. Finally, we emphasize the TME’s potential as a therapeutic target. Emerging strategies discussed in this review include harnessing the immune system (adoptive cell transfer, checkpoint blockade), hindering tumor angiogenesis, disrupting CAF activity, and manipulating ECM components. These approaches underscore the vital role that deciphering TME interactions plays in advancing cSCC therapy. Further research illuminating these complex relationships will uncover new avenues for developing more effective treatments for cSCC. Full article
(This article belongs to the Special Issue Tumor-Associated Microenvironments and Inflammation)
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16 pages, 2738 KiB  
Review
Oxidative Stress and Neurodegeneration: Insights and Therapeutic Strategies for Parkinson’s Disease
by Erjola Bej, Patrizia Cesare, Anna Rita Volpe, Michele d’Angelo and Vanessa Castelli
Neurol. Int. 2024, 16(3), 502-517; https://doi.org/10.3390/neurolint16030037 (registering DOI) - 29 Apr 2024
Abstract
Parkinson’s disease (PD) is a progressive neurodegenerative condition marked by the gradual deterioration of dopaminergic neurons in the substantia nigra. Oxidative stress has been identified as a key player in the development of PD in recent studies. In the first part, we [...] Read more.
Parkinson’s disease (PD) is a progressive neurodegenerative condition marked by the gradual deterioration of dopaminergic neurons in the substantia nigra. Oxidative stress has been identified as a key player in the development of PD in recent studies. In the first part, we discuss the sources of oxidative stress in PD, including mitochondrial dysfunction, dopamine metabolism, and neuroinflammation. This paper delves into the possibility of mitigating oxidative stress as a potential treatment approach for PD. In addition, we examine the hurdles and potential of antioxidant therapy, including the challenge of delivering antioxidants to the brain and the requirement for biomarkers to track oxidative stress in PD patients. However, even if antioxidant therapy holds promise, further investigation is needed to determine its efficacy and safety in PD treatment. Full article
(This article belongs to the Collection Advances in Neurodegenerative Diseases)
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14 pages, 2338 KiB  
Article
Development and Validation of a Novel Zero-Dimensional Heat Rejection Model for High-Efficiency Engines
by Francesca Furia, Vittorio Ravaglioli, Alberto Cerofolini and Carlo Bussi
Energies 2024, 17(9), 2116; https://doi.org/10.3390/en17092116 (registering DOI) - 29 Apr 2024
Abstract
In recent years, the trend towards the performance maximization of modern internal combustion engines has led to the creation of accurate simulation models to optimize the engine design and operating conditions. Temperature management is crucial to achieve the performance goals of an internal [...] Read more.
In recent years, the trend towards the performance maximization of modern internal combustion engines has led to the creation of accurate simulation models to optimize the engine design and operating conditions. Temperature management is crucial to achieve the performance goals of an internal combustion engine without affecting the component’s reliability. Formula 1 mandates that only a limited number of experimental tests can be performed, which leads to the necessity of simulators capable of substituting empirical tests. Furthermore, the requirement of adapting the vehicle setup before each race weekend to maximize the performance on each circuit layout necessitates short computational time. To address this, the development of a zero-dimensional model of the thermal flows within an engine is presented in this paper. This model allows to precisely compute the dynamic variations of all the heat flows inside the combustion engine, excluding only the radiative ones and the engine components’ temperatures. The new simulation approach has been developed and validated on a Formula 1 engine and shown to be precise and fast. The results demonstrate the value of the proposed model with an average engine fluid temperature error of less than 1 °C for a computational cost comparable with on-board applications. Full article
(This article belongs to the Special Issue Internal Combustion Engine: Research and Application—2nd Edition)
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16 pages, 2686 KiB  
Review
Ocular Drug Delivery into the Eyes Using Drug-Releasing Soft Contact Lens
by Toshihiko Tashima
Future Pharmacol. 2024, 4(2), 336-351; https://doi.org/10.3390/futurepharmacol4020019 (registering DOI) - 29 Apr 2024
Abstract
The impact of visual impairment, such as blindness, on quality of life is immeasurable. However, effective ocular drug delivery into the eyes has not yet been established, primarily due to the impermeability imposed by the blood–retinal barrier (BRB) based on the tight junctions [...] Read more.
The impact of visual impairment, such as blindness, on quality of life is immeasurable. However, effective ocular drug delivery into the eyes has not yet been established, primarily due to the impermeability imposed by the blood–retinal barrier (BRB) based on the tight junctions and efflux transporters at the endothelium or the epithelium in oral or intravenous administration, as well as the dilution with tear fluid and excretion through the nasolacrimal duct in eye drop administration. Furthermore, intravitreous injections induce pain and fear in patients. Unmet medical needs persist in ocular diseases such as age-related macular degeneration and diabetic retinopathy. Therefore, innovative non-invasive administration methods should be developed. Drug-releasing soft contact lenses (DR-SCLs) affixed to the eye’s surface can continuously and locally deliver their loaded drugs to the eyes. The use of DR-SCLs is expected to greatly enhance the bioavailability and patient adherence to the drug regimen. It is known that several solute carrier (SLC) transporters are expressed in various parts of the eyes, including the cornea, the ciliary body, and the bulbar conjunctiva. Carrier-mediated transport through SLC transporters may occur in addition to passive diffusion. Moreover, nanoparticles can be loaded into DR-SCLs, offering various intelligent approaches based on modifications to induce receptor-mediated endocytosis/transcytosis or to control the loaded drug release within this delivery system. In this perspective review, I discuss the implementation and potential of DR-SCL-mediated ocular drug delivery, particularly focusing on low-molecular-weight compounds because of their fine distribution in living body, ease of handling, and ease of manufacturing. Full article
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17 pages, 8091 KiB  
Article
Hot Corrosion Behavior of Plasma-Sprayed Gd2Zr2O7/YSZ Functionally Graded Thermal Barrier Coatings
by Rajasekaramoorthy Manogaran, Karthikeyan Alagu, Anderson Arul, Anandh Jesuraj, Dinesh Kumar Devarajan, Govindhasamy Murugadoss and Kamalan Kirubaharan Amirtharaj Mosas
Ceramics 2024, 7(2), 579-595; https://doi.org/10.3390/ceramics7020038 (registering DOI) - 29 Apr 2024
Abstract
The development of advanced thermal barrier coating (TBC) materials with better hot corrosion resistance, phase stability, and residual stresses is an emerging research area in the aerospace industry. In the present study, four kinds of TBCs, namely, single-layer yttria-stabilized zirconia (YSZ), single-layer gadolinium [...] Read more.
The development of advanced thermal barrier coating (TBC) materials with better hot corrosion resistance, phase stability, and residual stresses is an emerging research area in the aerospace industry. In the present study, four kinds of TBCs, namely, single-layer yttria-stabilized zirconia (YSZ), single-layer gadolinium zirconate (GZ), bilayer gadolinium zirconate/yttria-stabilized zirconia (YSZ/GZ), and a multilayer functionally graded coating (FGC) of YSZ and GZ, were deposited on NiCrAlY bond-coated nickel-based superalloy (Inconel 718) substrates using the atmospheric plasma spray technique. The hot corrosion behavior of the coatings was tested by applying a mixture of Na2SO4 and V2O5 onto the surface of TBC, followed by isothermal heat treatment at 1273 K for 50 h. The characterization of the corroded samples was performed by X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS) to identify physical and chemical changes in the coatings. GIXRD was used to analyze the residual stresses of the coatings. Residual stress in the FGC coating was found to be −15.2 ± 10.6 MPa. The wear resistance of TBCs is studied using a linear reciprocating tribometer, and the results indicate that gadolinium zirconate-based TBCs showed better performance when deposited in bilayer and multilayered functionally graded TBC systems. The wear rate of as-coated FGC coatings was determined to be 2.90 × 10−4 mm3/Nm, which is lower than the conventional YSZ coating. Full article
(This article belongs to the Special Issue Research Progress in Ceramic Coatings)
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21 pages, 1077 KiB  
Article
Pre-Service Teachers’ GenAI Anxiety, Technology Self-Efficacy, and TPACK: Their Structural Relations with Behavioral Intention to Design GenAI-Assisted Teaching
by Kai Wang, Qianqian Ruan, Xiaoxuan Zhang, Chunhua Fu and Boyuan Duan
Behav. Sci. 2024, 14(5), 373; https://doi.org/10.3390/bs14050373 (registering DOI) - 29 Apr 2024
Abstract
Generative artificial intelligence (GenAI) has taken educational settings by storm in the past year due to its transformative ability to impact school education. It is crucial to investigate pre-service teachers’ viewpoints to effectively incorporate GenAI tools into their instructional practices. Data gathered from [...] Read more.
Generative artificial intelligence (GenAI) has taken educational settings by storm in the past year due to its transformative ability to impact school education. It is crucial to investigate pre-service teachers’ viewpoints to effectively incorporate GenAI tools into their instructional practices. Data gathered from 606 pre-service teachers were analyzed to explore the predictors of behavioral intention to design Gen AI-assisted teaching. Based on the Unified Theory of Acceptance and Use of Technology (UTAUT) model, this research integrates multiple variables such as Technological Pedagogical Content Knowledge (TPACK), GenAI anxiety, and technology self-efficacy. Our findings revealed that GenAI anxiety, social influence, and performance expectancy significantly predicted pre-service teachers’ behavioral intention to design GenAI-assisted teaching. However, effort expectancy and facilitating conditions were not statistically associated with pre-service teachers’ behavioral intentions. These findings offer significant insights into the intricate relationships between predictors that influence pre-service teachers’ perspectives and intentions regarding GenAI technology. Full article
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