The 2023 MDPI Annual Report has
been released!
 
20 pages, 11156 KiB  
Article
Enhancing the Conductivity and Dielectric Characteristics of Bismuth Oxyiodide via Activated Carbon Doping
by Mohamed Khairy, Faisal K. Algethami, Abdullah N. Alotaibi, Rasmiah S. Almufarij and Babiker Y. Abdulkhair
Molecules 2024, 29(9), 2082; https://doi.org/10.3390/molecules29092082 (registering DOI) - 01 May 2024
Abstract
Activated carbon/BiOI nanocomposites were successfully synthesized through a simplistic method. The produced composites were then characterized using XRD, TEM, SEM-EDX, and XPS. The results showed that BiOI with a tetragonal crystal structure had been formed. The interaction between activated carbon and BiOI was [...] Read more.
Activated carbon/BiOI nanocomposites were successfully synthesized through a simplistic method. The produced composites were then characterized using XRD, TEM, SEM-EDX, and XPS. The results showed that BiOI with a tetragonal crystal structure had been formed. The interaction between activated carbon and BiOI was confirmed via all the mentioned tools. The obtained nanocomposites’ electrical conductivity, dielectric properties, and Ac impedance were studied at 59 KHz−1.29 MHz. AC and dc conductivities were studied at temperatures between 303 and 573 K within the frequency range of 59 KHz–1.29 MHz. The 10% activated carbon/BiOI nanocomposite possessed dc and AC conductivity values of 5.56 × 10−4 and 2.86 × 10−4 Ω−1.cm−1, respectively, which were higher than BiOI and the other nanocomposites. Every sample exhibited increased electrical conductivity values as the temperature and frequency rose, suggesting that all samples had semiconducting behavior. The loss and dielectric constants (ε′ and ε″) also dropped as the frequency increased, leading to higher dielectric loss. The Nyquist plot unraveled single semicircle arcs and a decreased bulk resistance, indicating decreased grain boundary resistance. Consequently, the electrical characteristics of BiOI, 1C/BiOI, 5C/BiOI, and 10C/BiOI implied their applicability as dielectric absorbers, charge-stored capacitors, and high-frequency microwave devices. Full article
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18 pages, 919 KiB  
Article
Intermediate Care for Patient-Centered Care, Shared Decision Making, and Hospital Discharge Support in a Japanese Acute Care Hospital: A Cross-Sectional Study
by Yuko Goto and Hisayuki Miura
Hospitals 2024, 1(1), 32-49; https://doi.org/10.3390/hospitals1010004 (registering DOI) - 01 May 2024
Abstract
[Background] Intermediate care is a limited-time service founded on patient-centered care (PCC) that ensures continuity and quality of care during the transition between home and acute care services, promotes recovery, and restores independence and confidence. In Japan, systematic education on intermediate care for [...] Read more.
[Background] Intermediate care is a limited-time service founded on patient-centered care (PCC) that ensures continuity and quality of care during the transition between home and acute care services, promotes recovery, and restores independence and confidence. In Japan, systematic education on intermediate care for care providers is lacking. [Method] The present study explored the relationship between a Japanese scale used to evaluate individualized discharge support skills, a Japanese version of a tool for evaluating intermediate care based on PCC, and a tool that measures the shared decision making of care providers, which is the pinnacle of PCC. [Results] Clear correlations were found between the concepts evaluated using these three tools. Some concepts were not correlated between the Japanese scale that evaluated individualized discharge support skills and intermediate care based on PCC. [Conclusions] Elucidating the perspectives that help expand discharge care to intermediate care based on PCC will contribute to future education on intermediate care for Japanese care providers and to enriching patient-centered intermediate care. Full article
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20 pages, 3266 KiB  
Article
A Framework for Upscaling of Emerging Chemical Processes Based on Thermodynamic Process Modeling and Simulation
by Hafiz Farooq Imtiaz
ChemEngineering 2024, 8(3), 46; https://doi.org/10.3390/chemengineering8030046 (registering DOI) - 01 May 2024
Abstract
Prospective environmental and technological assessment of emerging chemical processes is necessary to identify, analyze and evaluate the technologies that are highly imperative in the transition towards climate neutrality. The investigation of the environmental impacts and material and energy requirements of the processes at [...] Read more.
Prospective environmental and technological assessment of emerging chemical processes is necessary to identify, analyze and evaluate the technologies that are highly imperative in the transition towards climate neutrality. The investigation of the environmental impacts and material and energy requirements of the processes at the low technology readiness level (TRL) is important in making early decisions about the feasibility of adapting and upscaling the process to the industrial level. However, the upscaling of new chemical processes has always been a major challenge; and in this context, there is no general methodological guidance available in the literature. Hence, a new comprehensive methodological framework for upscaling of novel chemical processes is designed and presented based on thermodynamic process modeling and simulation. The practical implementation of the proposed methodology is extensively discussed by developing a scaled-up novel carbon capture and utilization (CCU) process comprised of sequestration of carbon dioxide (CO2) from blast furnace gas with a capacity of 1000 liter per hour (L/h) using methanol and its utilization as a precursor to produce methane (CH4). It was found that thermodynamic process modeling and simulations based on the perturbed-chain statistical associating (PC-SAFT) equation of state (EOS) can precisely estimate the CO2 solubility in methanol and conversion to CH4 at various temperature and pressure conditions. The achieved thermophysical property and kinetics parameters can be employed in process simulations to estimate scaled-up environmental flows and material and energy requirements of the process. Full article
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17 pages, 4478 KiB  
Article
Research on Damping Hole Optimization of Hydro-Pneumatic Suspension for Mining Trucks under Variable Load Conditions
by Wenfeng Zhu, Zenglu Zhao, Xingtong Zhou, Xuepeng Cao, Min Ye, Chuqing Cao and Mohammad Manjur Alam
Actuators 2024, 13(5), 163; https://doi.org/10.3390/act13050163 (registering DOI) - 01 May 2024
Abstract
The hydro-pneumatic suspension, known for enhancing vehicle ride comfort and stability, finds widespread use in engineering vehicles. Presently, the majority of mining trucks employ hydro-pneumatic suspension with a fixed damping hole, underscoring the critical importance of selecting appropriate damping hole parameters. Initially, an [...] Read more.
The hydro-pneumatic suspension, known for enhancing vehicle ride comfort and stability, finds widespread use in engineering vehicles. Presently, the majority of mining trucks employ hydro-pneumatic suspension with a fixed damping hole, underscoring the critical importance of selecting appropriate damping hole parameters. Initially, an equilibrium mathematical model of the ¼ hydro-pneumatic suspension is established, and the influencing factors of the damping characteristics are analyzed. Subsequently, the simulation model and experimental bench for the hydro-pneumatic suspension are constructed. Sinusoidal signals with different frequencies and amplitudes serve as the excitation signals to analyze the variation trend of the force on the rod with displacement changes. The simulation and experimental results demonstrate a high degree of consistency, validating the rationality and validity of the simulation model. Building upon this foundation, various damping apertures are then selected to study the damping characteristics of the hydro-pneumatic suspension. The research indicates that as the damping aperture increases, the setting time of the hydro-pneumatic suspension system after excitation extends, accompanied by a decrease in the acceleration overshoot. As a result, a comprehensive evaluation index is developed, considering various factors, such as different weight setting times and peak longitudinal accelerations to assess the ride comfort of the suspension. This approach is then employed to determine the optimal damping aperture under both full-load and no-load conditions. The findings of this research offer valuable insights for the development of adaptive variable damping hydraulic suspensions, especially under variable load conditions. Full article
(This article belongs to the Section Actuators for Land Transport)
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16 pages, 1073 KiB  
Article
Effect of Miscellaneous Meals Replacing Soybean Meal in Feed on Growth Performance, Serum Biochemical Parameters, and Microbiota Composition of 25–50 kg Growing Pigs
by Xianliang Zhan, Lei Hou, Zhentao He, Shuting Cao, Xiaolu Wen, Shuai Liu, Yaojie Li, Shaozhen Chen, Huayu Zheng, Dongyan Deng, Kaiguo Gao, Xuefen Yang, Zongyong Jiang and Li Wang
Animals 2024, 14(9), 1354; https://doi.org/10.3390/ani14091354 (registering DOI) - 30 Apr 2024
Abstract
The present study aims to determine the effect of miscellaneous meals (rapeseed meal, cottonseed meal, and sunflower meal) replacing soybean meal in feed on growth performance, apparent digestibility of nutrients, serum biochemical parameters, serum free amino acid content, microbiota composition and SCFAs content [...] Read more.
The present study aims to determine the effect of miscellaneous meals (rapeseed meal, cottonseed meal, and sunflower meal) replacing soybean meal in feed on growth performance, apparent digestibility of nutrients, serum biochemical parameters, serum free amino acid content, microbiota composition and SCFAs content in growing pigs (25–50 kg). A total of 72 (Duroc × Landrace × Yorkshire) growing pigs with initial weights of 25.79 ± 0.23 kg were randomly divided into three treatments. The pigs were fed corn–soybean meal (CON), corn–soybean–miscellaneous meals (CSM), and corn–miscellaneous meals (CMM). Each treatment included six replicates with four pigs per pen (n = 24, 12 barrows and 12 gilts). Soybean meal accounted for 22.10% of the basal diet in the CON group. In the CSM group, miscellaneous meals partially replaced soybean meal with a mixture of 4.50% rapeseed meal, 3.98% cottonseed meal, and 4.50% sunflower meal. In the CMM group, miscellaneous meals entirely replaced soybean meal with a mixture of 8.50% rapeseed meal, 8.62% cottonseed meal, and 8.5% sunflower. The results showed that compared with the CON, the CSM and CMM groups significantly improved the average daily gain (ADG) of growing pigs during the 25–50 kg stage (p < 0.05) but had no effects on average daily feed intake (ADFI) and average daily feed intake/average daily gain (F/G) (p > 0.05). Moreover, the CMM group significantly reduced nutrient apparent digestibility of gross energy compared with the CON group. The serum biochemical parameters results showed that the CSM group significantly improved the contents of total protein (TP) compared with the CON group (p < 0.05). The CMM group significantly improved the contents of total protein (TP), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) compared with the CON group in serum (p < 0.05). In comparison with the CON group, the CMM group also significantly improved lysine (Lys), threonine (Thr), valine (Val), isoleucine (Ile), leucine (Leu), phenylalanine (Phe), arginine (Arg), and citrulline (Cit) levels in serum (p < 0.05). However, the CMM group significantly decreased non-essential amino acid content glycine (Gly) in serum compared with CON (p < 0.05), while compared with the CON group, the CSM and CMM groups had no significant effects on the relative abundance, the alpha-diversity, or the beta-diversity of fecal microbiota. Moreover, compared with the CON group, the CSM group significantly increased butyric acid and valeric acid contents of short-chain fatty acids (SCFAs) in feces (p < 0.05). In contrast to the CON group, the CMM group significantly reduced the contents of SCFAs in feces, including acetic acid, propionic acid, and isobutyric acid (p < 0.05). Collectively, the results of the present study indicate that miscellaneous meals (rapeseed meal, cottonseed meal, and sunflower meal) can partially replace the soybean meal and significantly improve the growth performance of growing pigs during the 25–50 kg stage. Thus, miscellaneous meals are a suitable protein source as basal diets to replace soybean meals for 25–50 kg growing pigs. These results can be helpful to further develop miscellaneous meals as a functional alternative feed ingredient to soybean meal. Full article
(This article belongs to the Special Issue Exploration of Sustainable Feed Resources and Pig Dietary Strategies)
21 pages, 24631 KiB  
Article
The Effect of Ultrafine-Grained (UFG) Structure Formed by Equal-Channel Angular Pressing in AA7075 on Wear and Friction in Sliding against Steel and Ceramic Counterbodies
by Andrey V. Filippov, Sergei Y. Tarasov and Ekaterina O. Filippova
Metals 2024, 14(5), 527; https://doi.org/10.3390/met14050527 (registering DOI) - 30 Apr 2024
Abstract
The mechanical characteristics and sliding friction behaviors of AA7075 samples were studied in regard to structural states formed in them by ECAP and depending on the ECAP pass number. In addition, the effect of a counterbody’s material on the tribological characteristics of the [...] Read more.
The mechanical characteristics and sliding friction behaviors of AA7075 samples were studied in regard to structural states formed in them by ECAP and depending on the ECAP pass number. In addition, the effect of a counterbody’s material on the tribological characteristics of the samples was investigated by the examples of AISI 52100 steel, alumina Al2O3 and silicon nitride Si3N4. Vibration acceleration and acoustic emission signals with parameters such as acoustic emission energy and median frequency were used for characterizing the sliding regimes. The structural state and mechanical properties of the ECAPed AA7075 samples significantly affected their wear behaviors in dry sliding. The counterbody material had a significant influence on the formation of a transfer layer and the subsurface deformation of samples. The dynamic behavior of the tribosystem was studied and the relationship between the sliding parameters, vibrometry and acoustic emission signals was established. Full article
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12 pages, 369 KiB  
Article
Montelukast Influence on Lung in Experimental Diabetes
by Cristina Gales, Bogdan Stoica, Gabriela Rusu-Zota and Mihai Nechifor
Medicina 2024, 60(5), 749; https://doi.org/10.3390/medicina60050749 (registering DOI) - 30 Apr 2024
Abstract
Background and Objectives: The influence of montelukast (MK), an antagonist of cysLT1 leukotriene receptors, on lung lesions caused by experimental diabetes was studied. Materials and Methods: The study was conducted on four groups of six adult male Wistar rats. Diabetes was produced by [...] Read more.
Background and Objectives: The influence of montelukast (MK), an antagonist of cysLT1 leukotriene receptors, on lung lesions caused by experimental diabetes was studied. Materials and Methods: The study was conducted on four groups of six adult male Wistar rats. Diabetes was produced by administration of streptozotocin 65 mg/kg ip. in a single dose. Before the administration of streptozotocin, after 72 h, and after 8 weeks, the serum values of glucose, SOD, MDA, and total antioxidant capacity (TAS) were determined. After 8 weeks, the animals were anesthetized and sacrificed, and the lungs were harvested and examined by optical microscopy. Pulmonary fibrosis, the extent of lung lesions, and the lung wet-weight/dry-weight ratio were evaluated. Results: The obtained results showed that MK significantly reduced pulmonary fibrosis (3.34 ± 0.41 in the STZ group vs. 1.73 ± 0.24 in the STZ+MK group p < 0.01) and lung lesion scores and also decreased the lung wet-weight/dry-weight (W/D) ratio. SOD and TAS values increased significantly when MK was administered to animals with diabetes (77.2 ± 11 U/mL in the STZ group vs. 95.7 ± 13.3 U/mL in the STZ+MK group, p < 0.05, and 25.52 ± 2.09 Trolox units in the STZ group vs. 33.29 ± 1.64 Trolox units in the STZ+MK group, respectively, p < 0.01), and MDA values decreased. MK administered alone did not significantly alter any of these parameters in normal animals. Conclusions: The obtained data showed that by blocking the action of peptide leukotrienes on cysLT1 receptors, montelukast significantly reduced the lung lesions caused by diabetes. The involvement of these leukotrienes in the pathogenesis of fibrosis and other lung diabetic lesions was also demonstrated. Full article
(This article belongs to the Section Pharmacology)
22 pages, 6265 KiB  
Article
Hydrologic Sensitivity of a Critical Turkish Watershed to Inform Water Resource Management in an Altered Climate
by Furkan Yunus Emre Cevahir, Jennifer C. Adam, Mingliang Liu and Justin Sheffield
Hydrology 2024, 11(5), 64; https://doi.org/10.3390/hydrology11050064 (registering DOI) - 30 Apr 2024
Abstract
This study introduces a novel sensitivity analysis approach to assess the resilience and susceptibility of hydrologic systems to the stresses of climate change, moving away from conventional top-down methodologies. By exploring the hydrological sensitivity of the upper Kızılırmak River basin using the Variable [...] Read more.
This study introduces a novel sensitivity analysis approach to assess the resilience and susceptibility of hydrologic systems to the stresses of climate change, moving away from conventional top-down methodologies. By exploring the hydrological sensitivity of the upper Kızılırmak River basin using the Variable Infiltration Capacity (VIC) hydrologic model, we employed a sensitivity-based approach as an alternative to the traditional Global Climate Model (GCM)-based methods, providing more insightful information for water managers. Considering the consistent projections of increasing temperature over this region in GCMs, the hydrologic system was perturbed to examine gradients of a more challenging climate characterized by warming and drying conditions. The sensitivity of streamflow, snow water equivalent, and evapotranspiration to temperature (T) and precipitation (P) variations under each perturbation or “reference” climate was quantified. Results indicate that streamflow responds to T negatively under all warming scenarios. As the reference climates become drier, streamflow sensitivity to P increases, indicating that meteorological drought impacts on water availability could be exacerbated. These results suggest that there will be heightened difficulty in managing water resources in the region if it undergoes both warming and drying due to the following setbacks: (1) water availability will shift away from the summer season of peak water demand due to the warming effects on the snowpack, (2) annual water availability will likely decrease due to a combination of warming and lower precipitation, and (3) streamflow sensitivity to hydroclimatic variability will increase, meaning that there will be more extreme impacts to water availability. Water managers will need to plan for a larger set of extreme conditions. Full article
(This article belongs to the Special Issue Runoff Modelling under Climate Change)
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21 pages, 1479 KiB  
Article
Unlock Happy Interactions: Voice Assistants Enable Autonomy and Timeliness
by Linlin Mo, Liangbo Zhang, Xiaohui Sun and Zhimin Zhou
J. Theor. Appl. Electron. Commer. Res. 2024, 19(2), 1013-1033; https://doi.org/10.3390/jtaer19020053 (registering DOI) - 30 Apr 2024
Abstract
This study examines the effects of three interactive voice assistant (VA) features (responsiveness, ubiquitous connectivity, and personalization) on consumer happiness. An online survey was administered to 316 VA consumers, and the data were analyzed using structural equation modeling with SmartPLS 4 software. The [...] Read more.
This study examines the effects of three interactive voice assistant (VA) features (responsiveness, ubiquitous connectivity, and personalization) on consumer happiness. An online survey was administered to 316 VA consumers, and the data were analyzed using structural equation modeling with SmartPLS 4 software. The results indicate that VA responsiveness, ubiquitous connectivity, and personalization have significant effects on consumer happiness. This study also provides evidence that consumer happiness is influenced by VA features through the mediating roles of autonomy and timeliness. Notably, perceived privacy risk has a dual effect, negatively affecting happiness but positively moderating the relationship between autonomy and happiness, suggesting a complex interplay between benefits and concerns in user interactions with VAs. This study highlights the need for VA businesses to consider both the enhancing and mitigating factors of technology for user experiences. Furthermore, our findings have significant implications for VA businesses and executives, suggesting that improved interactions through these VA features can better serve consumers and enhance their experiences. Full article
(This article belongs to the Topic Consumer Psychology and Business Applications)
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21 pages, 384 KiB  
Article
Corporate Risk-Taking, Innovation Efficiency, and High-Quality Development: Evidence from Chinese Firms
by Yongxia Wu, Haiqing Hu and Meng Xue
Systems 2024, 12(5), 154; https://doi.org/10.3390/systems12050154 - 30 Apr 2024
Abstract
Facing the increasingly complex and uncertain external environment, the reasonable control of investment risk is the key to realizing the sound operation and high-quality development of enterprises. Based on the innovation perspective, this paper takes A-share non-financial listed companies from 2007 to 2021 [...] Read more.
Facing the increasingly complex and uncertain external environment, the reasonable control of investment risk is the key to realizing the sound operation and high-quality development of enterprises. Based on the innovation perspective, this paper takes A-share non-financial listed companies from 2007 to 2021 as the research sample to explore the impact of the corporate risk-taking level on the high-quality development of enterprises and examines the transmission mechanism of the relationship between the two from the perspectives of innovation efficiency, innovation input, and innovation output. It is found that enterprise risk-taking significantly inhibits the high-quality development of enterprises, by reducing innovation efficiency; innovation efficiency plays a mediating role in the influence of the relationship between the two, which is mainly due to the fact that enterprise risk-taking increases the innovation inputs of enterprises but reduces the innovation outputs of enterprises, and then reduces the innovation efficiency of enterprises and inhibits the high-quality development of enterprises. This heterogeneity study finds that the inhibitory effect of corporate risk-taking on the high-quality development of firms is more pronounced among manufacturing firms, small-scale firms, and firms with higher capital intensity. The findings of this study provide both guidance to help enterprises to reduce risky investment decision-making behaviors and experience for regulators to effectively promote the formulation of policies related to the high-quality development of the real economy. Full article
19 pages, 554 KiB  
Article
A Simplified Method for the Evaluation of Floating-Body Motion Responses over a Sloping Bottom
by Xiaolei Liu, Kun Gu, Zhijia Qian, Sheng Ding, Kan Wang, Hao Wang and Chen Sun
J. Mar. Sci. Eng. 2024, 12(5), 756; https://doi.org/10.3390/jmse12050756 (registering DOI) - 30 Apr 2024
Abstract
Recently, many floating renewable energy platforms have been deployed in coastal regions, where sloping bottoms are an important factor when evaluating their safety. In this article, a simplified method coupling an eigenfunction matching method (EMM) and a finite-depth Green’s function (FDGF) is developed [...] Read more.
Recently, many floating renewable energy platforms have been deployed in coastal regions, where sloping bottoms are an important factor when evaluating their safety. In this article, a simplified method coupling an eigenfunction matching method (EMM) and a finite-depth Green’s function (FDGF) is developed to evaluate floating-body motion responses over a sloping bottom for which bathymetry is homogeneous in the longshore direction. We propose an extended EMM to create an incident wave model over the sloping bottom, thereby obtaining the Froude–Krylov (F–K) force and Neumann data on the wet surfaces of the floating body for the diffraction problem. An equivalent depth is introduced to account for the interaction between the sloping bottom and floating bodies when dealing with the diffraction and radiation problems. The accuracy of the present method is validated through a comprehensive comparison with numerical and/or experiment results for a liquefied natural gas (LNG) ship and a floating hemisphere from the literature. Generally, the present, simplified method can give predictions with sufficient accuracy. Full article
(This article belongs to the Section Ocean Engineering)
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9 pages, 2586 KiB  
Communication
TiO2-Coated Meltblown Nonwoven Fabrics Prepared via Atomic Layer Deposition for the Inactivation of E. coli as a Model Photocatalytic Drinking Water Treatment System
by Alexander G. Aragon, Jaime A. Cárdenas Sánchez, Carlos Zimeri, Eunkyoung Shim, Xiaomeng Fang and Kyana R. L. Young
Environments 2024, 11(5), 92; https://doi.org/10.3390/environments11050092 (registering DOI) - 30 Apr 2024
Abstract
The controlled manufacturing of semiconductor photocatalysts is crucial to their development for drinking water treatment. In this study, TiO2-coated meltblown nonwoven fabrics prepared via Atomic Layer Deposition (ALD) are applied for the inactivation of Escherichia coli (E. coli). It [...] Read more.
The controlled manufacturing of semiconductor photocatalysts is crucial to their development for drinking water treatment. In this study, TiO2-coated meltblown nonwoven fabrics prepared via Atomic Layer Deposition (ALD) are applied for the inactivation of Escherichia coli (E. coli). It is observed that in the presence of an ultraviolet light-emitting diode (UV-LED) light source (255 nm), 1.35 log E. coli inactivation is achieved. However, exposure to catalyst-coated fabrics in addition to the light source resulted in >4 log E. coli inactivation, suggesting a much higher rate of hydroxyl radical formation on the surface, leading to cell death. Full article
(This article belongs to the Special Issue Advanced Technologies of Water and Wastewater Treatment)
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22 pages, 954 KiB  
Review
Mechanisms of Pulmonary Vasculopathy in Acute and Long-Term COVID-19: A Review
by Marianne Riou, Florence Coste, Alain Meyer, Irina Enache, Samy Talha, Anne Charloux, Cyril Reboul and Bernard Geny
Int. J. Mol. Sci. 2024, 25(9), 4941; https://doi.org/10.3390/ijms25094941 (registering DOI) - 30 Apr 2024
Abstract
Despite the end of the pandemic, coronavirus disease 2019 (COVID-19) remains a major public health concern. The first waves of the virus led to a better understanding of its pathogenesis, highlighting the fact that there is a specific pulmonary vascular disorder. Indeed, COVID-19 [...] Read more.
Despite the end of the pandemic, coronavirus disease 2019 (COVID-19) remains a major public health concern. The first waves of the virus led to a better understanding of its pathogenesis, highlighting the fact that there is a specific pulmonary vascular disorder. Indeed, COVID-19 may predispose patients to thrombotic disease in both venous and arterial circulation, and many cases of severe acute pulmonary embolism have been reported. The demonstrated presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) within the endothelial cells suggests that direct viral effects, in addition to indirect effects of perivascular inflammation and coagulopathy, may contribute to pulmonary vasculopathy in COVID-19. In this review, we discuss the pathological mechanisms leading to pulmonary vascular damage during acute infection, which appear to be mainly related to thromboembolic events, an impaired coagulation cascade, micro- and macrovascular thrombosis, endotheliitis and hypoxic pulmonary vasoconstriction. As many patients develop post-COVID symptoms, including dyspnea, we also discuss the hypothesis of pulmonary vascular damage and pulmonary hypertension as a sequela of the infection, which may be involved in the pathophysiology of long COVID. Full article
(This article belongs to the Special Issue Current Research for Heart Disease Biology and Therapeutics 2.0)
18 pages, 2079 KiB  
Article
Direct Numerical Modeling as a Tool for Optical Coherence Tomography Development: SNR (Sensitivity) and Lateral Resolution Test Target Interpretation
by Samuel Lawman and Yao-Chun Shen
Photonics 2024, 11(5), 419; https://doi.org/10.3390/photonics11050419 (registering DOI) - 30 Apr 2024
Abstract
Optical Coherence Tomography (OCT) is a growing family of biophotonic imaging techniques, but in the literature there is a lack of easy-to-use tools to universally directly evaluate a device’s theoretical performance for a given metric. Modern computing tools mean that direct numerical modeling [...] Read more.
Optical Coherence Tomography (OCT) is a growing family of biophotonic imaging techniques, but in the literature there is a lack of easy-to-use tools to universally directly evaluate a device’s theoretical performance for a given metric. Modern computing tools mean that direct numerical modeling can, from first principles, simulate the performance metrics of a specific device directly without relying on analytical approximations and/or complexities. Here, we present two different direct numerical models, along with the example MATLAB code for the reader to adapt to their own systems. The first model is of photo-electron shot noise at the detector, the primary noise source for OCT. We use this firstly to evaluate the amount of additional noise present (1.5 dB) for an experimental setup. Secondly, we demonstrate how to use it to precisely quantify the expected shot noise SNR limit difference between time-domain and Fourier-domain OCT systems in a given hypothetical experiment. The second model is used to demonstrate how USAF 1951 test chart images should be interpreted for a given lateral PSF shape. Direct numerical modeling is an easy and powerful basic tool for researchers and developers, the wider use of which may improve the rigor of the OCT literature. Full article
(This article belongs to the Special Issue Recent Progress in Biophotonics)
23 pages, 5702 KiB  
Article
DS-Trans: A 3D Object Detection Method Based on a Deformable Spatiotemporal Transformer for Autonomous Vehicles
by Yuan Zhu, Ruidong Xu, Chongben Tao, Hao An, Huaide Wang, Zhipeng Sun and Ke Lu
Remote Sens. 2024, 16(9), 1621; https://doi.org/10.3390/rs16091621 (registering DOI) - 30 Apr 2024
Abstract
Facing the significant challenge of 3D object detection in complex weather conditions and road environments, existing algorithms based on single-frame point cloud data struggle to achieve desirable results. These methods typically focus on spatial relationships within a single frame, overlooking the semantic correlations [...] Read more.
Facing the significant challenge of 3D object detection in complex weather conditions and road environments, existing algorithms based on single-frame point cloud data struggle to achieve desirable results. These methods typically focus on spatial relationships within a single frame, overlooking the semantic correlations and spatiotemporal continuity between consecutive frames. This leads to discontinuities and abrupt changes in the detection outcomes. To address this issue, this paper proposes a multi-frame 3D object detection algorithm based on a deformable spatiotemporal Transformer. Specifically, a deformable cross-scale Transformer module is devised, incorporating a multi-scale offset mechanism that non-uniformly samples features at different scales, enhancing the spatial information aggregation capability of the output features. Simultaneously, to address the issue of feature misalignment during multi-frame feature fusion, a deformable cross-frame Transformer module is proposed. This module incorporates independently learnable offset parameters for different frame features, enabling the model to adaptively correlate dynamic features across multiple frames and improve the temporal information utilization of the model. A proposal-aware sampling algorithm is introduced to significantly increase the foreground point recall, further optimizing the efficiency of feature extraction. The obtained multi-scale and multi-frame voxel features are subjected to an adaptive fusion weight extraction module, referred to as the proposed mixed voxel set extraction module. This module allows the model to adaptively obtain mixed features containing both spatial and temporal information. The effectiveness of the proposed algorithm is validated on the KITTI, nuScenes, and self-collected urban datasets. The proposed algorithm achieves an average precision improvement of 2.1% over the latest multi-frame-based algorithms. Full article
11 pages, 407 KiB  
Communication
Availability of Receptors for Advanced Glycation End-Products (RAGE) Influences Differential Transcriptome Expression in Lungs from Mice Exposed to Chronic Secondhand Smoke (SHS)
by Katrina L. Curtis, Ashley Chang, Ryan Van Slooten, Christian Cooper, Madison N. Kirkham, Thomas Armond, Zack deBernardi, Brett E. Pickett, Juan A. Arroyo and Paul R. Reynolds
Int. J. Mol. Sci. 2024, 25(9), 4940; https://doi.org/10.3390/ijms25094940 (registering DOI) - 30 Apr 2024
Abstract
The receptor for advanced glycation end-products (RAGE) has a central function in orchestrating inflammatory responses in multiple disease states including chronic obstructive pulmonary disease (COPD). RAGE is a transmembrane pattern recognition receptor with particular interest in lung disease due to its naturally abundant [...] Read more.
The receptor for advanced glycation end-products (RAGE) has a central function in orchestrating inflammatory responses in multiple disease states including chronic obstructive pulmonary disease (COPD). RAGE is a transmembrane pattern recognition receptor with particular interest in lung disease due to its naturally abundant pulmonary expression. Our previous research demonstrated an inflammatory role for RAGE following acute exposure to secondhand smoke (SHS). However, chronic inflammatory mechanisms associated with RAGE remain ambiguous. In this study, we assessed transcriptional outcomes in mice exposed to chronic SHS in the context of RAGE expression. RAGE knockout (RKO) and wild-type (WT) mice were delivered nose-only SHS via an exposure system for six months and compared to control mice exposed to room air (RA). We specifically compared WT + RA, WT + SHS, RKO + RA, and RKO + SHS. Analysis of gene expression data from WT + RA vs. WT + SHS showed FEZ1, Slpi, and Msln as significant at the three-month time point; while RKO + SHS vs. WT + SHS identified cytochrome p450 1a1 and Slc26a4 as significant at multiple time points; and the RKO + SHS vs. WT + RA revealed Tmem151A as significant at the three-month time point as well as Gprc5a and Dynlt1b as significant at the three- and six-month time points. Notable gene clusters were functionally analyzed and discovered to be specific to cytoskeletal elements, inflammatory signaling, lipogenesis, and ciliogenesis. We found gene ontologies (GO) demonstrated significant biological pathways differentially impacted by the presence of RAGE. We also observed evidence that the PI3K-Akt and NF-κB signaling pathways were significantly enriched in DEGs across multiple comparisons. These data collectively identify several opportunities to further dissect RAGE signaling in the context of SHS exposure and foreshadow possible therapeutic modalities. Full article
(This article belongs to the Special Issue Advanced Glycation End Products (AGEs) and Their Receptor RAGE)
25 pages, 1353 KiB  
Review
Review of Fuel-Cell Electric Vehicles
by Tingke Fang, Coleman Vairin, Annette von Jouanne, Emmanuel Agamloh and Alex Yokochi
Energies 2024, 17(9), 2160; https://doi.org/10.3390/en17092160 (registering DOI) - 30 Apr 2024
Abstract
This paper presents an overview of the status and future prospects of fuel-cell electric vehicles (FC-EVs). As global concerns about emissions escalate, FC-EVs have emerged as a promising substitute for traditional internal combustion engine vehicles. This paper discusses the fundamentals of fuel-cell technology [...] Read more.
This paper presents an overview of the status and future prospects of fuel-cell electric vehicles (FC-EVs). As global concerns about emissions escalate, FC-EVs have emerged as a promising substitute for traditional internal combustion engine vehicles. This paper discusses the fundamentals of fuel-cell technology considering the major types of fuel cells that have been researched and delves into the most suitable fuel cells for FC-EV applications, including comparisons with mainstream vehicle technologies. The present state of FC-EVs, ongoing research, and the challenges and opportunities that need to be accounted for are discussed. Furthermore, the comparison between promising proton-exchange membrane fuel cell (PEMFC) and solid oxide fuel cell (SOFC) technologies used in EVs provides valuable insights into their respective strengths and challenges. By synthesizing these aspects, the paper aims to provide a comprehensive understanding and facilitate decision-making for future advancements in sustainable FC-EV transportation, thereby contributing to the realization of a cleaner, greener, and more environmentally friendly future. Full article
(This article belongs to the Section E: Electric Vehicles)
12 pages, 7132 KiB  
Communication
Deterministic Global 3D Fractal Cloud Model for Synthetic Scene Generation
by Aaron M. Schinder, Shannon R. Young, Bryan J. Steward, Michael Dexter, Andrew Kondrath, Stephen Hinton and Ricardo Davila
Remote Sens. 2024, 16(9), 1622; https://doi.org/10.3390/rs16091622 (registering DOI) - 30 Apr 2024
Abstract
This paper describes the creation of a fast, deterministic, 3D fractal cloud renderer for the AFIT Sensor and Scene Emulation Tool (ASSET). The renderer generates 3D clouds by ray marching through a volume and sampling the level-set of a fractal function. The fractal [...] Read more.
This paper describes the creation of a fast, deterministic, 3D fractal cloud renderer for the AFIT Sensor and Scene Emulation Tool (ASSET). The renderer generates 3D clouds by ray marching through a volume and sampling the level-set of a fractal function. The fractal function is distorted by a displacement map, which is generated using horizontal wind data from a Global Forecast System (GFS) weather file. The vertical windspeed and relative humidity are used to mask the creation of clouds to match realistic large-scale weather patterns over the Earth. Small-scale detail is provided by the fractal functions which are tuned to match natural cloud shapes. This model is intended to run quickly, and it can run in about 700 ms per cloud type. This model generates clouds that appear to match large-scale satellite imagery, and it reproduces natural small-scale shapes. This should enable future versions of ASSET to generate scenarios where the same scene is consistently viewed from both GEO and LEO satellites from multiple perspectives. Full article
(This article belongs to the Section Atmospheric Remote Sensing)
20 pages, 1556 KiB  
Article
Particle Swarm-Optimized Fuzzy Logic Energy Management of Hybrid Energy Storage in Electric Vehicles
by Joseph Omakor, Mohamad Alzayed and Hicham Chaoui
Energies 2024, 17(9), 2163; https://doi.org/10.3390/en17092163 (registering DOI) - 30 Apr 2024
Abstract
A lithium-ion battery–ultracapacitor hybrid energy storage system (HESS) has been recognized as a viable solution to address the limitations of single battery energy sources in electric vehicles (EVs), especially in urban driving conditions, owing to its complementary energy features. However, an energy management [...] Read more.
A lithium-ion battery–ultracapacitor hybrid energy storage system (HESS) has been recognized as a viable solution to address the limitations of single battery energy sources in electric vehicles (EVs), especially in urban driving conditions, owing to its complementary energy features. However, an energy management strategy (EMS) is required for the optimal performance of the HESS. In this paper, an EMS based on the particle swarm optimization (PSO) of the fuzzy logic controller (FLC) is proposed. It aims to minimize battery current and power peak fluctuations, thereby enhancing its capacity and lifespan, by optimizing the weights of formulated FLC rules using the PSO algorithm. This paper utilizes the battery temperature as the cost function in the optimization problem of the PSO due to the sensitivity of lithium-ion batteries (LIBs) to operating temperature variations compared to ultracapacitors (UCs). An evaluation of optimized FLC using PSO and a developed EV model is conducted under the Urban Dynamometer Driving Schedule (UDDS) and compared with the unoptimized FLC. The result shows that 5.4% of the battery’s capacity was conserved at 25.5 C, which is the highest operating temperature attained under the proposed strategy. Full article
25 pages, 21352 KiB  
Article
Parametric Optimization of Friction Stir Welding of AA6061-T6 Samples Using the Copper Donor Stir-Assisted Material Method
by Aiman H. Al-Allaq, Joseph Maniscalco, Srinivasa Naik Bhukya, Zhenhua Wu and Abdelmageed Elmustafa
Metals 2024, 14(5), 536; https://doi.org/10.3390/met14050536 (registering DOI) - 30 Apr 2024
Abstract
This study presents an optimization of the process parameters for the effect of copper (Cu) donor material percentage on the friction stir welding (FSW) of AA6061-T6 alloy. Extensive factorial experiments were conducted to determine the significance of the rotational speed (ω), the transverse [...] Read more.
This study presents an optimization of the process parameters for the effect of copper (Cu) donor material percentage on the friction stir welding (FSW) of AA6061-T6 alloy. Extensive factorial experiments were conducted to determine the significance of the rotational speed (ω), the transverse speed (v), the interface coefficient of friction (μ), and the Cu donor material percentage in the plunge, left, right, and downstream zones. Design Expert 13 software was used to identify the number of simulation experiments to be conducted using the Abaqus simulation software. From Design Expert 13, which is a thorough multi-objective optimization analysis software, we were able to identify ideal welding parameters such as a rotational speed of 1222 rpm, transverse speed of 1.1 mm/s, the coefficient of friction of 0.9, and a 19% donor material percentage for the plunge zone. Significant findings demonstrate that increasing the Cu donor material substantially reduced the temperature from 502 °C to 134 °C when the Cu content is increased from 0% to 50%. This integrated modeling and optimization approach provides a practical procedure to identify the best experimental parameters for the process and a new understanding to guide advances for high-quality FSW of aluminum alloys. This work offers a methodology for optimizing the FSW parameters aligned with multifaceted thermomechanical physics. Full article
(This article belongs to the Special Issue Advances in Friction Stir Welding of Alloys and Metals)
22 pages, 2330 KiB  
Article
Modes of Weather System-Induced Flows through an Arctic Lagoon
by Chunyan Li, Wei Huang, Changsheng Chen, Kevin M. Boswell and Renhao Wu
J. Mar. Sci. Eng. 2024, 12(5), 767; https://doi.org/10.3390/jmse12050767 (registering DOI) - 30 Apr 2024
Abstract
With the increasing warming of the Arctic, the summertime ice-free period in the coastal Arctic becomes longer and the water exchange between arctic lagoons and coastal Beaufort Sea becomes more important for land–ocean interaction. This study examined the dynamics of water exchange between [...] Read more.
With the increasing warming of the Arctic, the summertime ice-free period in the coastal Arctic becomes longer and the water exchange between arctic lagoons and coastal Beaufort Sea becomes more important for land–ocean interaction. This study examined the dynamics of water exchange between the arctic lagoons and the Arctic Ocean under the influence of weather systems (the transient arctic cyclones and hovering Beaufort High pressure system). We implemented rare observations, numerical modeling with the Finite Volume Community Ocean Model (FVCOM), and a forcing-response Empirical Orthogonal Function (fr-EOF) analysis to determine the weather-driven flow patterns and characteristics in the micro-tidal arctic lagoon (Elson Lagoon) with little freshwater discharge. The results were validated for both tidal and subtidal currents with in situ data. The inlets of the lagoon were significantly impacted by wind associated with the weather systems and the flows through the inlets were highly correlated with each other. The fr-EOF analysis for the 1.5-month FVCOM output indicated three significant modes of wind-driven flow. In the deepest (~16 m) northwestern-most inlet, a counter-wind flow occurred more than 96% of the time due to setup and set down of water level inside the lagoon and the vorticity balance related to the wind stress and water depth. For about 60–80% of the time, the exchange flow was out of the lagoon through the northwestern-most and deepest inlet due to the strong easterly winds dictated by the Beaufort High; this dominant flow is mainly caused by the persistent easterly wind as a limb of the Beaufort High pressure system, modified by the transient arctic cyclones with a westerly wind and inward flows at the westernmost inlet of Elson Lagoon. This study shows that the alternating influence from the cyclone-anticyclone weather systems produces a meteorological tide in the subtidal spectrum which dominates the water exchange in the region through the multiple inlets. With the observed increase in cyclone strength and frequency under the warming trend, this may imply a greater contribution from the westerly wind because of the increased cyclonic activities. If this is the case, the inward flow might increase and have an effect on sediment, larval, and nutrient transports through this system. Full article
(This article belongs to the Special Issue Hydrodynamic Circulation Modelling in the Marine Environment)
25 pages, 2346 KiB  
Article
The Significance of Tree Height as a Predictor of Tree Mortality during Bark Beetle Outbreaks in a Small Catchment
by Susanne I. Schmidt, Hana Fluksová, Stanislav Grill and Jiří Kopáček
Forests 2024, 15(5), 803; https://doi.org/10.3390/f15050803 (registering DOI) - 30 Apr 2024
Abstract
Bark beetle outbreaks damage forests and kill trees worldwide, but many aspects of their dynamics remain unexplained. Our aim was to identify predictors for individual tree deaths within the small (0.7 km2) Plešné Lake catchment in the Šumava National Park in [...] Read more.
Bark beetle outbreaks damage forests and kill trees worldwide, but many aspects of their dynamics remain unexplained. Our aim was to identify predictors for individual tree deaths within the small (0.7 km2) Plešné Lake catchment in the Šumava National Park in southwestern Czechia. Within this area, >60,000 trees were geo-referenced and categorized from ten aerial images (20 cm spatial resolution) between 2000 and 2015. For each year for which aerial images were available, we calculated tree densities of different categories and diameters. Tree height was evaluated by means of LiDAR in two terrestrial campaigns (2010 and 2011). A machine learning technique was then used to evaluate the most important variables. The resulting relationships were largely nonlinear and differed among years; however, individual trait tree height proved to be the most influential variable in each year. Higher trees were more likely to have died during either the undisturbed phase (2000 and 2003), the disturbed phase (2005–2011), or the recovery phase (2013). Our results indicate that salvage logging may not be the most effective measure for protecting trees in small catchments. Full article
(This article belongs to the Section Natural Hazards and Risk Management)
23 pages, 1791 KiB  
Article
Fast and Fault-Tolerant Passive Hyperbolic Localization Using Sensor Consensus
by Gyula Simon and Gergely Zachár
Sensors 2024, 24(9), 2891; https://doi.org/10.3390/s24092891 (registering DOI) - 30 Apr 2024
Abstract
The accuracy of passive hyperbolic localization applications using Time Difference of Arrival (TDOA) measurements can be severely compromised in non-line-of-sight (NLOS) situations. Consensus functions have been successfully used to provide robust and accurate location estimates in such challenging situations. In this paper, a [...] Read more.
The accuracy of passive hyperbolic localization applications using Time Difference of Arrival (TDOA) measurements can be severely compromised in non-line-of-sight (NLOS) situations. Consensus functions have been successfully used to provide robust and accurate location estimates in such challenging situations. In this paper, a fast branch-and-bound computational method for finding the global maximum of consensus functions is proposed and the global convergence property of the algorithm is mathematically proven. The performance of the method is illustrated by simulation experiments and real measurements. Full article
(This article belongs to the Section Navigation and Positioning)

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