A retrospective study at the 4th Military Clinical Hospital in Wroclaw, Poland, assessed PCR testing alongside blood cultures to guide antimicrobial therapy decisions in hospitalized patients, to determine how much time the results of the molecular tests preceded conventional methods. Among 118 patients, Staphylococcus aureus (37%) and Escherichia coli (21%) were the most common bloodstream infection agents. Blood cultures utilized the BacT/ALERT 3D system, and molecular diagnostics were conducted using the FilmArray platform with the BIOFIRE BCID2 panel. Methicillin susceptibility was observed in 66% of S. aureus strains, while 26% of Gram-negative bacilli exhibited an ESBL phenotype. Therapeutic decisions based on molecular test results were often incorrect for S. aureus infections, particularly MSSA (64.5%), but generally accurate for Gram-negative bacilli. The median times from positive blood culture to BCID2 and pathogen identification/susceptibility were 10 h and 52 h, respectively. Molecular diagnostics facilitated faster initiation of appropriate antibiotic therapy, highlighting the need to educate medical staff on proper interpretation. Consulting within an antimicrobial stewardship program (ASP) could enhance the benefits of implementing molecular methods in bloodstream infection diagnostics. Full article

Even though inhalation dosimetry is determined by three factors (i.e., breathing, aerosols, and the respiratory tract), the first two categories have been more widely studied than the last. Both breathing and aerosols are quantitative variables that can be easily changed, while respiratory airway morphologies are difficult to reconstruct, modify, and quantify. Although several methods are available for model reconstruction and modification, developing an anatomically accurate airway model and morphing it to various physiological conditions remains labor-intensive and technically challenging. The objective of this study is to explore the feasibility of using an adjoint–CFD model to understand airway shape effects on vapor deposition and control vapor flux into the lung. A mouth–throat model was used, with the shape of the mouth and tongue being automatically varied via adjoint morphing and the vapor transport being simulated using ANSYS Fluent coupled with a wall absorption model. Two chemicals with varying adsorption rates, Acetaldehyde and Benzene, were considered, which exhibited large differences in dosimetry sensitivity to airway shapes. For both chemicals, the maximal possible morphing was first identified and then morphology parametric studies were conducted. Results show that changing the mouth–tongue shape can alter the oral filtration by 3.2% for Acetaldehyde and 0.27% for Benzene under a given inhalation condition. The front tongue exerts a significant impact on all cases considered, while the impact of other regions varies among cases. This study demonstrates that the hybrid adjoint–CFD approach can be a practical and efficient method to investigate morphology-associated variability in the dosimetry of vapors and nanomedicines under steady inhalation. Full article

Phosphorus- and arsenic-containing cobalt clusters are an interesting class of compounds that continue to provide new structures with captivating bonding patterns. Although the first members of this family were reported 45 years ago, the number of such species is still limited within the broad family of transition metal complexes bearing pnictogen atoms. Herein, we present the reaction of Co₂(CO)₈ as a cobalt source with a number of phosphorus- and arsenic-containing compounds under variable reaction conditions. These reactions result in various known and novel cobalt phosphorus and cobalt arsenic clusters in which different nuclearity ratios between P/As and Co exist. All those clusters were characterized by X-ray structural analysis and partly by IR, ³¹P{¹H} NMR, EI-MS and elemental analysis. This comprehensive study is the first detailed study in this field that reveals the richness of compounds that could be obtained only by modifying the ratio of used reactants and the involved reaction conditions. Full article

Thrombosis is the pathological clot formation under abnormal hemodynamic conditions, which can result in vascular obstruction, causing ischemic strokes and myocardial infarction. Thrombus growth under moderate to low shear (<1000 s${}^{-1}$) relies on platelet activation and coagulation. Thrombosis at elevated high shear rates (>10,000 s${}^{-1}$) is predominantly driven by unactivated platelet binding and aggregating mediated by von Willebrand factor (VWF), while platelet activation and coagulation are secondary in supporting and reinforcing the thrombus. Given the molecular and cellular level information it can access, multiscale computational modeling informed by biology can provide new pathophysiological mechanisms that are otherwise not accessible experimentally, holding promise for novel first-principle-based therapeutics. In this review, we summarize the key aspects of platelet biorheology and mechanobiology, focusing on the molecular and cellular scale events and how they build up to thrombosis through platelet adhesion and aggregation in the presence or absence of platelet activation. In particular, we highlight recent advancements in multiscale modeling of platelet biorheology and mechanobiology and how they can lead to the better prediction and quantification of thrombus formation, exemplifying the exciting paradigm of digital medicine. Full article

This study employs copula functions to establish the dependency structure of the joint distribution among rainfall intensity, wind speed, and wind direction in Qatar. Based on a Vine Copula, the trivariate distribution between rainfall intensity, wind speed, and wind direction is found to exhibit a root-mean-square error (RMSE) of 0.0072 on the observed vs. modeled cumulative probabilities using ranked normalized observations. It is also found that the winter Shamal winds are most pronounced during rainfall. However, a secondary component of easterly winds known as the Kaus winds is also found to exert an important influence. This wind pattern is observable during rainfall at all the selected stations, albeit with minor variations. It is also found that rainfall stations where the rainfall is obstructed in any way from northwest to north and from east to southeast significantly influence the rainfall measurements. Specific rain gauges in Qatar are found to be situated in disrupted surroundings, such as meteorological stations close to passing traffic, where road spray could infiltrate the rain gauge funnel, impacting the accuracy of rainfall measurements. The study results necessitated the relocation of approximately half of these roadside gauges to mitigate wind-induced biases from road spray. An evaluation of operations is recommended for approximately 80 meteorological stations responsible for measuring rainfall in Qatar. The methodology devised in this study holds potential for application to other Middle Eastern countries and regions with similar climates. Full article

Background: Bimatoprost has emerged as a significant medication in the field of medicine over the past several decades, with diverse applications in ophthalmology, dermatology, and beyond. Originally developed as an ocular hypotensive agent, it has proven highly effective in treating glaucoma and ocular hypertension. Its ability to reduce intraocular pressure has established it as a first-line treatment option, improving management and preventing vision loss. In dermatology, bimatoprost has shown promising results in the promotion of hair growth, particularly in the treatment of alopecia and hypotrichosis. Its mechanism of action, stimulating the hair cycle and prolonging the growth phase, has led to the development of bimatoprost-containing solutions for enhancing eyelash growth. Aim: The aim of our review is to provide a brief description, overview, and studies in the current literature regarding the versatile clinical use of bimatoprost in recent years. This can help clinicians determine the most suitable individualized therapy to meet the needs of each patient. Methods: Our methods involve a comprehensive review of the latest advancements reported in the literature in bimatoprost formulations, which range from traditional eye drops to sustained-release implants. These innovations offer extended drug delivery, enhance patient compliance, and minimize side effects. Results: The vast literature published on PubMed has confirmed the clinical usefulness of bimatoprost in lowering intraocular pressure and in managing patients with glaucoma. Numerous studies have shown promising results in dermatology and esthetics in promoting hair growth, particularly in treating alopecia and hypotrichosis. Its mechanism of action involves stimulating the hair cycle and prolonging the growth phase, leading to the development of solutions that enhance eyelash growth. The global use of bimatoprost has expanded significantly, with applications growing beyond its initial indications. Ongoing research is exploring its potential in glaucoma surgery, neuroprotection, and cosmetic procedures. Conclusions: Bimatoprost has shown immense potential for addressing a wide range of therapeutic needs through various formulations and advancements. Promising future perspectives include the exploration of novel delivery systems such as contact lenses and microneedles to further enhance drug efficacy and patient comfort. Ongoing research and future perspectives continue to shape its role in medicine, promising further advancements and improved patient outcomes. Full article

Cotton is an important plant-based protein. Cottonseed cake, a byproduct of the biodiesel industry, offers potential in animal supplementation, although the presence of the antinutritional sesquiterpenoid gossypol limits utilization. The macrofungus Panus lecomtei offers potential in detoxification of antinutritional factors. Through an enzymatic and proteomic analysis of P. lecomtei strain BRM044603, grown on crushed whole cottonseed contrasting in the presence of free gossypol (FG), this study investigated FG biodegradation over a 15-day cultivation period. Fungal growth reduced FG to levels at 100 μg/g, with a complex adaptive response observed, involving primary metabolism and activation of oxidative enzymes for metabolism of xenobiotics. Increasing activity of secreted laccases correlated with a reduction in FG, with enzyme fractions degrading synthetic gossypol to trace levels. A total of 143 and 49 differentially abundant proteins were observed across the two contrasting growth conditions after 6 and 12 days of cultivation, respectively, revealing a dynamic protein profile during FG degradation, initially related to constitutive metabolism, then later associated with responses to oxidative stress. The findings advance our understanding of the mechanisms involved in gossypol degradation and highlight the potential of P. lecomtei BRM044603 in cotton waste biotreatment, relevant for animal supplementation, sustainable resource utilization, and bioremediation. Full article

The global scientific community is intensively promoting energy-plus buildings. Following the leading world trends, this paper presents a new energy-plus building concept—elevational earth-sheltered buildings with three different types of horizontal overhang photovoltaic-integrated panels: wooden support columns covered with clay tiles, steel pipes as support columns covered with sheet steel, and concrete support columns with concrete coverage. In this instance, the specific multi-numerical case study building model for the city of Kragujevac (located in central Serbia with favorable climatic conditions) was performed over 7 months (from 1 October to 30 April), taking into account the soil temperature, the effects of solar shading, the performance of the heating system—a ground source heat pump—and the characteristics of the artificial and automatic lighting control system. The simulation results show that the optimal depth of a horizontal overhang (energy-plus status) depends on the occupant’s habits, in addition to meteorological conditions. The presented methodology can be used for any other location, both in Europe and the world. Full article

Peptides with antimicrobial activity or protease inhibitory activity are potential candidates to supplement traditional antibiotics or cancer chemotherapies. However, the potential of many peptides are limited by drawbacks such as cytotoxicity or susceptibility to hydrolysis. Therefore, strategies to modify the structure of promising peptides may represent an effective approach for developing more promising clinical candidates. In this study, the mature peptide OSTI−1949, a Kunitz-type inhibitor from Odorrana schmackeri, and four designed analogues were successfully synthesised. In contrast to the parent peptide, the analogues showed impressive multi-functionality including antimicrobial, anticancer, and trypsin inhibitory activities. In terms of safety, there were no obvious changes observed in the haemolytic activity at the highest tested concentration, and the analogue OSTI−2461 showed an increase in activity against cancer cell lines without cytotoxicity to normal cells (HaCaT). In summary, through structural modification of a natural Kunitz-type peptide, the biological activity of analogues was improved whilst retaining low cytotoxicity. The strategy of helicity enhancement by forming an artificial α-helix and ß-sheet structure provides a promising way to develop original bioactive peptides for clinical therapeutics. Full article

To address the inherent challenges of deep space exploration, such as communication delays and the unpredictability of spacecraft environments, this study focuses on enhancing spacecraft adaptability and autonomy, which are essential for Autonomous Space Scientific Exploration. A pivotal aspect of this endeavor is the advancement of spacecraft task scheduling, which is integral to increasing spacecraft autonomy. Current research in this domain predominantly revolves around mission timing planning and is primarily executed from ground stations. However, these plans often lack the granularity required for direct implementation by spacecraft. In response, our study proposes an innovative approach to augment spacecraft autonomy, introducing a method that articulately describes mission objectives and resource information. We designed a novel hierarchical task network-timeline (HTN-T) algorithm, an amalgamation of the HTN scheduling method and the distinctive elements of existing research. This algorithm addresses time constraints through horizontal and vertical expansions, building upon the resolution of logical constraints found in conventional planning methods. Furthermore, it introduces a priority-based strategy for resolving resource conflicts in spacecraft tasks. This algorithm is substantiated through validation, including proof-of-principle demonstrations and assessments within a Space–ground Collaborative Management and Control System encompassing both ground and spacecraft operations. The findings indicate that our proposed algorithm achieves high rates of scheduling success and operational efficiency within a feasible timeframe, thus effectively navigating the complexities of autonomous spacecraft task scheduling. Full article

The characteristics of linear hydroelastic waves propagating in a channel covered with compressed ice are investigated. The channel has a rectangular cross-section and is assumed to be infinite in length. The fluid in the channel is non-viscous and incompressible; its flow is potential. The ice cover is modelled by an elastic plate of constant thickness frozen to the channel walls. Principal attention is paid to the investigation of the influence of ice compression on the parameters of hydroelastic waves. The problem is solved in a coupled hydroelastic formulation. The profiles of propagating waves in the channel are sought in the form of series on the normal modes of a dry plate. The modes are defined analytically through trigonometric and hyperbolic functions. It is shown that compression in the longitudinal and transverse directions has different effects on the dispersion relations of these hydroelastic waves, their shape and phase, as well as on the critical velocities and strains distribution. Full article

Thyroid Cancer (TC) is the most common endocrine malignancy, with increasing incidence globally. Papillary thyroid cancer (PTC), a differentiated form of TC, accounts for approximately 90% of TC and occurs predominantly in women of childbearing age. Although responsive to current treatments, recurrence of PTC by middle age is common and is much more refractive to treatment. Undifferentiated TC, particularly anaplastic thyroid cancer (ATC), is the most aggressive TC subtype, characterized by it being resistant and unresponsive to all therapeutic and surgical interventions. Further, ATC is one of the most aggressive and lethal malignancies across all cancer types. Despite the differences in therapeutic needs in differentiated vs. undifferentiated TC subtypes, there is a critical unmet need for the identification of molecular biomarkers that can aid in early diagnosis, prognosis, and actionable therapeutic targets for intervention. Advances in the field of cancer genomics have enabled for the elucidation of differential gene expression patterns between tumors and healthy tissue. A novel category of molecules, known as non-coding RNAs, can themselves be differentially expressed, and extensively contribute to the up- and downregulation of protein coding genes, serving as master orchestrators of regulated and dysregulated gene expression patterns. These non-coding RNAs have been identified for their roles in driving carcinogenic patterns at various stages of tumor development and have become attractive targets for study. The identification of specific genes that are differentially expressed can give insight into mechanisms that drive carcinogenic patterns, filling the gaps of deciphering molecular and cellular processes that modulate TC subtypes, outside of well-known driver mutations. Full article

The authors present an analysis of the correlation between demographic and territorial indicators and greenhouse gas (GHG) emissions, emphasizing the spatial aspect using statistical methods. Particular attention is given to the application of correlation techniques, considering the spatial correlation between the involved variables, such as demographic, territorial, and environmental indicators. The demographic data include factors such as population, demographic distribution, and population density; territorial indicators include land use, particularly settlements, and road soil occupancy. The aims of this study are as follows: (1) to identify the direct relationships between these variables and emissions; (2) to evaluate the spatial dependence between geographical entities; and (3) to contribute to generating a deeper understanding of the phenomena under examination. Using spatial autocorrelation analysis, our study aims to provide a comprehensive framework of the territorial dynamics that influence the quantity of emissions. This approach can contribute to formulating more targeted environmental policies, considering the spatial nuances that characterize the relationships between demographics, territory, and GHGs. The outcome of this research is the identification of a direct formula to obtain greenhouse gas emissions from data about land use starting from the case study of Pavia Province in Italy. In the paper, the authors highlight different methodologies to compare land use and GHG emissions to select the most feasible correlation formula. The proposed procedure has been tested and can be used to promote awareness of the spatial dimension in the analysis of complex interactions between anthropogenic factors and environmental impacts. Full article

IoT has seen remarkable growth, particularly in healthcare, leading to the rise of IoMT. IoMT integrates medical devices for real-time data analysis and transmission but faces challenges in data security and interoperability. This research identifies a significant gap in the existing literature regarding a comprehensive ontology for vulnerabilities in medical IoT devices. This paper proposes a fundamental domain ontology named MIoT (Medical Internet of Things) ontology, focusing on cybersecurity in IoMT (Internet of Medical Things), particularly in remote patient monitoring settings. This research will refer to similar-looking acronyms, IoMT and MIoT ontology. It is important to distinguish between the two. IoMT is a collection of various medical devices and their applications within the research domain. On the other hand, MIoT ontology refers to the proposed ontology that defines various concepts, roles, and individuals. MIoT ontology utilizes the knowledge engineering methodology outlined in Ontology Development 101, along with the structured life cycle, and establishes semantic interoperability among medical devices to secure IoMT assets from vulnerabilities and cyberattacks. By defining key concepts and relationships, it becomes easier to understand and analyze the complex network of information within the IoMT. The MIoT ontology captures essential key terms and security-related entities for future extensions. A conceptual model is derived from the MIoT ontology and validated through a case study. Furthermore, this paper outlines a roadmap for future research, highlighting potential impacts on security automation in healthcare applications. Full article

The three-pronged sliding universal coupling is a new kind of three-pronged coupling. The purpose of this study is to demonstrate that, compared with a traditional unequal angular velocity universal coupling (such as the Hooke universal coupling), the universal coupling has the superior characteristics of constant angular speed transmission, simple structure and strong transmission capacity by performing kinematic and dynamic analysis of the new three-pronged sliding constant angular velocity universal coupling. It provides a broad prospect for applications in automotive and other fields. To study its kinematic and dynamic characteristics, directional cosine matrices are utilized as tools to analyze the coordinate systems by establishing simplified geometric models and corresponding motions. Through the analysis of the motions of the input and output shafts and employing the method of single-force element, a set of equilibrium equations for the forces acting on the output shaft and the input shaft are formulated for solution analysis. The research indicates that during the rotation process, there exists a small angular difference between the input shaft and the intermediate shaft, demonstrating the quasi-constant angular velocity characteristics of the new tripod sliding universal coupling. The curves of the forces and force moment acting on each component of the coupling approximate sinusoidal curves. The optimal operating angle range for the new tripod universal coupling is at angle , during which the system exhibits good transmission and mechanical performance. It can be widely used in the automobile industry, tie steel industry and other occasions that require angular transmission. It is especially used in high-speed operation and large transmission capacity. Full article

Duplex stainless steels are materials with high performance under mechanical stress and stress corrosion in chloride ion environments. Despite being used in many new applications such as components for offshore drilling platforms as well as in the chemical and petrochemical industry, the automotive industry, etc., they face issues of wear and hardness that limit current applications and prevent the creation of new use opportunities. To address these shortcomings, it is proposed to develop a hardfacing process by a special welding technique using a universal TIG source adapted for manual welding with a pulsed current, and a manganese austenitic alloy electrode as filler material. The opportunity to deposit layers of manganese austenitic steel through welding creates advantages related to the possibility of achieving high mechanical characteristics of this steel exclusively in the working area of the part, while the substrate material will not undergo significant changes in chemical composition. As a result of the high strain hardening rate, assisted mainly by mechanical twinning, manganese austenitic alloys having a face-centered cubic crystal lattice (f.c.c) and low stacking fault energy (SFE = 20–40 mJ/m²) at room temperature, exhibit high wear resistance and exceptional toughness. Following cold deformation, the hardness of the deposited metal increases to 465 HV5–490 HV5. The microstructural characteristics were investigated through optical microscopy (OM), scanning electron microscopy (SEM), energy-dispersive X-ray analysis (EDX), X-ray diffraction (XRD), and Vickers hardness measurements (HV). The obtained results highlighted the feasibility of forming hard coatings on duplex stainless steel substrates. Full article

(1) Background: Home sleep apnea testing, known as polysomnography type 3 (PSG3), underestimates respiratory events in comparison with in-laboratory polysomnography type 1 (PSG1). Without head electrodes for scoring sleep and arousal, in a home environment, patients feel unfettered and move their bodies more naturally. Adopting a natural position may decrease obstructive sleep apnea (OSA) severity in PSG3, independently of missing hypopneas associated with arousals. (2) Methods: Patients with suspected OSA performed PSG1 and PSG3 in a randomized sequence. We performed an additional analysis, called reduced polysomnography, in which we blindly reassessed all PSG1 tests to remove electroencephalographic electrodes, electrooculogram, and surface electromyography data to estimate the impact of not scoring sleep and arousal-based hypopneas on the test results. A difference of 15 or more in the apnea–hypopnea index (AHI) between tests was deemed clinically relevant. We compared the group of patients with and without clinically relevant differences between lab and home tests (3) Results: As expected, by not scoring sleep, there was a decrease in OSA severity in the lab test, similar to the home test results. The group of patients with clinically relevant differences between lab and home tests presented more severe OSA in the lab compared to the other group (mean AHI, 42.5 vs. 20.2 events/h, p = 0.002), and this difference disappeared in the home test. There was no difference between groups in the shift of OSA severity by abolishing sleep scoring in the lab. However, by comparing lab and home tests, there were greater variations in supine AHI and time spent in the supine position in the group with a clinically relevant difference, either with or without scoring sleep, showing an impact of the site of the test on body position during sleep. These variations presented as a marked increase or decrease in supine outcomes according to the site of the test, with no particular trend. (4) Conclusions: In-lab polysomnography may artificially increase OSA severity in a subset of patients by inducing marked changes in body position compared to home tests. The location of the sleep test seems to interfere with the evaluation of patients with more severe OSA. Full article

Erythropoiesis is initiated with the transformation of multipotent hematopoietic stem cells into committed erythroid progenitor cells in the erythroblastic islands of the bone marrow in adults. These cells undergo several stages of differentiation, including erythroblast formation, normoblast formation, and finally, the expulsion of the nucleus to form mature red blood cells. The erythropoietin (EPO) pathway, which is activated by hypoxia, induces stimulation of the erythroid progenitor cells and the promotion of their proliferation and survival as well as maturation and hemoglobin synthesis. The regulation of erythropoiesis is a complex and dynamic interaction of a myriad of factors, such as transcription factors (GATA-1, STAT5), cytokines (IL-3, IL-6, IL-11), iron metabolism and cell cycle regulators. Multiple microRNAs are involved in erythropoiesis, mediating cell growth and development, regulating oxidative stress, erythrocyte maturation and differentiation, hemoglobin synthesis, transferrin function and iron homeostasis. This review aims to explore the physiology of steady-state erythropoiesis and to outline key mechanisms involved in ineffective erythropoiesis linked to anemia, chronic inflammation, stress, and hematological malignancies. Studying aberrations in erythropoiesis in various diseases allows a more in-depth understanding of the heterogeneity within erythroid populations and the development of gene therapies to treat hematological disorders. Full article

Thermal events in lead-acid batteries during their operation play an important role; they affect not only the reaction rate of ongoing electrochemical reactions, but also the rate of discharge and self-discharge, length of service life and, in critical cases, can even cause a fatal failure of the battery, known as “thermal runaway.” This contribution discusses the parameters affecting the thermal state of the lead-acid battery. It was found by calculations and measurements that there is a cooling component in the lead-acid battery system which is caused by the endothermic discharge reactions and electrolysis of water during charging, related to entropy change contribution. Thus, under certain circumstances, it is possible to lower the temperature of the lead-acid battery during its discharging. The Joule heat generated on the internal resistance of the cell due to current flow, the exothermic charging reaction, and above all, the gradual increase in polarization as the cell voltage increases during charging all contribute to the heating of the cell, overtaking the cooling effect. Of these three sources of thermal energy, Joule heating in polarization resistance contributes the most to the temperature rise in the lead-acid battery. Thus, the maximum voltage reached determines the slope of the temperature rise in the lead-acid battery cell, and by a suitably chosen limiting voltage, it is possible to limit the danger of the “thermal runaway” effect. The overall thermal conditions of the experimental cell are significantly affected by the ambient temperature of the external environment and the rate of heat transfer through the walls of the calorimeter. A series of experiments with direct temperature measurement of individual locations within a lead-acid battery uses a calorimeter made of expanded polystyrene to minimize external influences. A hitherto unpublished phenomenon is discussed whereby the temperature of the positive electrode was lower than that of the negative electrode throughout the discharge, while during charging, the order was reversed and the temperature of the positive electrode was higher than that of the negative electrode throughout the charge. The authors relate this phenomenon to the higher reaction entropy change of the active mass of the positive electrode than that of the negative electrode. Full article

This study investigated the main microbial groups characterizing the interior surface of oak barrels from different years (1890, 1895, 1920, 1975, 2008) used in the production of vino cotto. The yeasts were characterized for the following properties: γ-aminobutyric acid (GABA) production, antioxidant activity, air–liquid interfacial biofilm formation, and anthocyanin adsorption capacity. Community-level physiological profile analysis revealed that the microbial communities inside the barrels used the tested carbon sources in different manners. The following yeast species were identified: Millerozyma farinosa, Zygosaccharomyces bisporus, Wickerhamiella versatilis, Zygosaccharomyces bailii, Starmerella lactis-condensi, and Zygosaccharomyces rouxii. All the strains were able to produce GABA, and S. lactis-condensi, Z. bisporus and Z. rouxii were the highest producers (more than 600 mg/L). The Z. rouxii and Z. bailii strains showed the highest antioxidant activity. Only seven strains out of ten M. farinosa formed air–liquid interfacial biofilm. None of the M. farinosa strains adsorbed anthocyanins on their cell wall. The other strains adsorbed anthocyanins in a strain-dependent way, and the highest adsorption was observed for the W. versatilis strains. The yeasts isolated in this study could be used to increase the functional properties and the quality of fermented foods and beverages. Full article

This paper presents a new technique for estimating the two-dimensional direction of departure (2D-DOD) and direction of arrival (2D-DOA) in bistatic uniform planar array Multiple-Input Multiple-Output (MIMO) radar systems. The method is based on the reduced-dimension (RD) MUSIC algorithm, aiming to achieve improved precision and computational efficiency. Primarily, this pioneering approach efficiently transforms the four-dimensional (4D) estimation problem into two-dimensional (2D) searches, thus reducing the computational complexity typically associated with conventional MUSIC algorithms. Then, exploits the spatial diversity of array response vectors to construct a 4D spatial spectrum function, which is crucial in resolving the complex angular parameters of multiple simultaneous targets. Finally, the objective is to simplify the spatial spectrum to a 2D search within a 4D measurement space to achieve an optimal balance between efficiency and accuracy. Simulation results validate the effectiveness of our proposed algorithm compared to several existing approaches, demonstrating its robustness in accurately estimating 2D-DOD and 2D-DOA across various scenarios. The proposed technique shows significant computational savings and high-resolution estimations and maintains high precision, setting a new benchmark for future explorations in the field. Full article

Viscoelastic materials are applied in several fields, and their relaxation characteristics are intricately related to the failure mechanism of sealing components and the generation of indentation rolling resistance in belt conveyors. Therefore, it is imperative to explore the relaxation characteristics of viscoelastic materials using characterization models. This article focuses on exploring these characterization models and the indentation rolling resistance of viscoelastic materials. The research comprises the following aspects: (1) A 2N + 2 element generalized Maxwell constitutive model is proposed for the relaxation behavior of viscoelastic materials to address the limitations of conventional relaxation models. (2) We conducted numerical calculations based on the relaxation modulus to solve the relaxation spectrum using several relaxation spectrum models. The findings showed that the model parameters were dependent on the testing time range. (3) The relationship between the indentation rolling resistance and relaxation model parameters was evaluated based on the theoretical foundation of the indentation rolling resistance calculation. Full article