We review the role of the spectral condition as a characteristic of Minkowski, de Sitter, and anti-de Sitter quantum field theories. We also discuss the role of plane waves that are compatible with the relevant analyticity domains linked to the spectral condition(s) and discuss harmonic analysis in terms of them. Full article

The spatiotemporal expression patterns of genes are crucial for maintaining normal physiological functions in animals. Conditional gene knockout using the cyclization recombination enzyme (Cre)/locus of crossover of P1 (Cre/LoxP) strategy has been extensively employed for functional assays at specific tissue or developmental stages. This approach aids in uncovering the associations between phenotypes and gene regulation while minimizing interference among distinct tissues. Various Cre-engineered mouse models have been utilized in the male reproductive system, including Dppa3-MERCre for primordial germ cells, Ddx4-Cre and Stra8-Cre for spermatogonia, Prm1-Cre and Acrv1-iCre for haploid spermatids, Cyp17a1-iCre for the Leydig cell, Sox9-Cre for the Sertoli cell, and Lcn5/8/9-Cre for differentiated segments of the epididymis. Notably, the specificity and functioning stage of Cre recombinases vary, and the efficiency of recombination driven by Cre depends on endogenous promoters with different sequences as well as the constructed Cre vectors, even when controlled by an identical promoter. Cre mouse models generated via traditional recombination or CRISPR/Cas9 also exhibit distinct knockout properties. This review focuses on Cre-engineered mouse models applied to the male reproductive system, including Cre-targeting strategies, mouse model screening, and practical challenges encountered, particularly with novel mouse strains over the past decade. It aims to provide valuable references for studies conducted on the male reproductive system. Full article

The aim of this study was to determine the associations between the front and back squat, countermovement jump (CMJ) and deep squat jump (DSJ) force–time metrics, and weightlifting performance in top-level weightlifters. Thirteen top-level weightlifters who classified for the World Championship 2023 participated. The heaviest successful snatch and clean and jerk were recorded within a preparation session as performance indicators. The front and back squat one-repetition maximums (1RMs) were evaluated in separate training sessions. The average of three maximum CMJs and DSJs were recorded using a force plate, and jump height, propulsive net impulse, and peak power were calculated for further analysis. Pearson’s correlation coefficients were used to determine the associations between variables. Statistical significance was set at p ≤ 0.05. The front and back squat 1RMs were significant and nearly perfectly associated with weightlifting performance (p < 0.001, r = 0.98–0.99). CMJ and DSJ propulsive net impulse displayed nearly perfect associations with weightlifting performance (p < 0.001, r = 0.96–0.99), while jump height is a less promising metric to assess the weightlifters’ ballistic capabilities. This study reinforces that lower body maximum strength and ballistic capabilities are closely associated with top-level weightlifters’ performance and are of practical importance to monitor their neuromuscular function. Full article

Spillways are essential control structures in hydroelectric dams for evacuating excess water during periods of high-water flow. These structures are generally excavated within a rock mass, without lining, and they take the form of a flow channel or a plunge pool. Rock mass erosion is an important issue facing engineers when designing unlined spillways. Methods commonly used to analyze this phenomenon are based on the threshold line concept, i.e., the correlation between rock mass resistance and its destruction against the erosive force of water. Multiple indices have been proposed for both rock mass quality and water energy (or erosive force) to assess rock mass erosion. The selection of appropriate indices is critical when evaluating hydraulic erosion. The erosive force of water is often represented by energy dissipation; however, other parameters, including average flow velocity and shear stress at the bottom of the flow channel, may also be relevant. Thus, a critical question is framed: which index best represents the erosive force of water? Here, we develop an approach to assess the applicability of the various indices used to represent the erosive force of water by relying on erosional events at more than 100 study sites. We determine that the most relevant parameters are linked to water pressure, as pressure head and flow velocity better explain the erosive force of the water than shear stress and water dissipation energy. Full article

Puerto de Cajas serves as a vital high-altitude passage in Ecuador, connecting the coastal region to the city of Cuenca. The stability of this rocky massif is carefully managed through the assessment of blocks and discontinuities, ensuring safe travel. This study presents a novel approach, employing rapid and cost-effective methods to evaluate an unexplored area within the protected expanse of Cajas. Using terrestrial photogrammetry and strategically positioned geomechanical stations along the slopes, we generated a detailed point cloud capturing elusive terrain features. We have used terrestrial photogrammetry for digitalization of the slope. Validation of the collected data was achieved by comparing directional data from Cloud Compare software with manual readings using a digital compass integrated in a phone at control points. The analysis encompasses three slopes, employing the SMR, Q-slope, and kinematic methodologies. Results from the SMR system closely align with kinematic analysis, indicating satisfactory slope quality. Nonetheless, continued vigilance in stability control remains imperative for ensuring road safety and preserving the site’s integrity. Moreover, this research lays the groundwork for the creation of a publicly accessible 3D repository, enhancing visualization capabilities through Google Virtual Reality. This initiative not only aids in replicating the findings but also facilitates access to an augmented reality environment, thereby fostering collaborative research endeavors. Full article

Meat quality and shelf life are important parameters affecting consumer perception and safety. Several factors contribute to the deterioration and spoilage of meat products, including microbial growth, chemical reactions in the food’s constituents, protein denaturation, lipid oxidation, and discoloration. This study reviewed the development of functional packaging biomaterials that interact with food and the environment to improve food’s sensory properties and consumer safety. Bioactive packaging incorporates additive compounds such as essential oils, natural extracts, and chemical substances to produce composite polymers and polymer blends. The findings showed that the incorporation of additive compounds enhanced the packaging’s functionality and improved the compatibility of the polymer–polymer matrices and that between the polymers and active compounds. Food preservatives are alternative substances for food packaging that prevent food spoilage and preserve quality. The safety of food contact materials, especially the flavor/odor contamination from the packaging to the food and the mass transfer from the food to the packaging, was also assessed. Flavor is a key factor in consumer purchasing decisions and also determines the quality and safety of meat products. Novel functional packaging can be used to preserve the quality and safety of packaged meat products. Full article

The COVID-19 pandemic significantly impacted global development. Through bioaerosols emitted by human respiration, respiratory infectious diseases, including COVID-19, are transmitted. The bioaerosol concentrations can be affected by the urban climate and morphology. However, the effects of urban green spaces on bioaerosol concentrations remain unclear. Focusing on the dormitory area of Beijing Forestry University, this study first investigated the influence of different green space ratios on the average bioaerosol concentrations using the ENVI-met software. Moreover, both overall and local green space layouts were analyzed for their impact on bioaerosol concentrations. The results indicated that ventilation conditions were the primary factor influencing bioaerosol concentrations. During peak congestion, a 10% increase in the green space ratio resulted in a 2% rise in the average bioaerosol concentration. Furthermore, a distributed layout resulted in a 1.3% higher average bioaerosol concentration than a concentrated layout with an equivalent green space ratio. Enacting strategies such as Roadside Green Spaces Retreat, Road Spaces Expansion, and Intersection Green Spaces Chamfering led to reductions in local bioaerosol concentrations by up to 17.7%, 18.44%, and 12.69%, respectively. This study highlights the importance of adjusting green space layouts in urban high-density areas after the pandemic, reducing the risk of population exposure to bioaerosol concentrations. Full article

This paper examines the effects of collapsible soil structure on shear wave velocity. The study attempts to simulate hydraulic fill sand deposits, which represent a natural soil deposition process that can result in a collapsible soil structure. A series of resonant column tests and bender element tests on Ottawa sand was conducted on sand specimens and prepared by dry pluviation and simulated hydraulic fill methods subjected to various confining pressures. Shear wave velocities measured from both methods of deposition are compared and discussed. Results from this study show that for soil specimens with the same void ratio, samples prepared by simulated hydraulic fill have a lower shear modulus and shear wave velocity than the specimens prepared by dry pluviation, and the differences are more pronounced at higher confining pressures. The resonant column test results performed in this study were consistent with results from the discrete element analysis, full-scale testing, and centrifuge testing. The discrete element analysis suggests that soil fabric and number of particle contacts are the key factors affecting the shear wave velocity. These factors are dependent on the methods of deposition. Results from this study examining hydraulic fill collapsible structure shear wave velocity provide a step forward toward a better correlation between soil dynamic properties measured in field and laboratory tests. Full article

This article proposes a new deadbeat predictive current control (DPCC) method based on a sliding-mode observer (SMO), which is applied in the field of permanent magnet motor control. A novel DPCC control method based on SMO is proposed according to the inherent issues of DPCC, which can effectively suppress internal parameter mismatch disturbances and external disturbances in the current loop. The mathematical model and derivation process of the proposed method are introduced. A simulation model is built and the effectiveness of the proposed method is verified. An experimental platform is built and the superiority of the proposed method is verified based on comparative experiments. Experimental results show that the proposed algorithm has strong robustness to the motor parameter mismatch. Compared with extended state observer (ESO) and adaptive observer (AO), the proposed algorithm has faster response speed and higher steady-state accuracy. Full article

The condition of a catenary is significant to ensure a high current collection quality. Owing to the dynamic interaction between the pantograph and the catenary system, the vibration of the pantograph can be used to analyze the condition of the catenary system. Therefore, we developed a novel diagnosis system based on the correlation between catenary defects and pantograph vibration. The proposed system is capable of detecting the type and location of commonly encountered defects in rigid support catenary systems. Catenary positioning coefficient and enhanced sample entropy methods were proposed for the extraction of defect features, and subsequently, linear discriminate analysis was used to diagnose the type and location of the catenary defects. Finally, the proposed defect detection and diagnosis system was applied to a commercial metro line, and the results verified the reliability and effectiveness of this diagnosis system. Full article

The lower limits of petrophysical properties for an effective reservoir are among the key parameters for assessing hydrocarbon reserves and are therefore directly related to hydrocarbon exploration and development strategies. However, the lower limits for marine sandstone gas reservoirs are still not clear and the impact factors also remain to be discussed. This study analysed the lower petrophysical property limits of an effective sandstone reservoir in the Qiongdongnan Basin using porosity, permeability and gas testing. The results showed that the lower porosity and permeability limits of effective reservoirs developed in the deltas are 8.9% and 1.2 × 10⁻³ μm², respectively, and 11.3% and 4.0 × 10⁻³ μm² in the submarine canyons and fans, respectively. Sedimentary facies, sediment transport distance, grain size and burial depth of sandstone significantly influence the lower physical property limits. The lower porosity and permeability limits increase with the increase in sediment transport distance as well as the decrease in sandstone grain size and burial depth. Sediment sources and sedimentary facies determine whether sandstone can become an effective reservoir in the Qiongdongnan Basin. Specifically, the sediment source dramatically influences the petrophysical properties of sandstone. The sandstone sourced from the Red River has higher porosity and permeability, followed by the sandstone sourced from the Hainan Uplift, and the sandstone sourced from the palaeo-uplift within the basin has the lowest porosity and permeability. The feldspar dissolution by CO₂ and organic acid is the primary formation mechanism of the effective reservoir in the Lingshui Formation, whereas the dissolution of glauconite is more common in the sandstone reservoirs of the Sanya and Meishan formations. Full article

In order to ascertain the mechanical properties and fracture performance of AA6016 aluminum sheets after cold forming and heat treatment processes, uniaxial tensile tests and fracture tests were conducted under various pre-strain conditions and heat treatment parameters. The experimental outcomes demonstrated that pre-strain and heat treatment had significant impacts on both stress–strain curves and fracture properties. Pre-strain plays a predominant role in influencing the mechanical and fracture properties. The behavior of precipitation hardening under different pre-strains was investigated using Differential Scanning Calorimetry (DSC). The results indicated that pre-strain accelerates the precipitation of the β″ strengthening phase, but excessive pre-strain can inhibit the heat treatment strengthening effect. To consider the influences of pre-strain and heat treatment, a constitutive model, as well as a predictive model for load–displacement curves, was established using a backpropagation (BP) neural network. An analysis of the number of hidden layers and neuron nodes in the network revealed that the accuracy of the model does not necessarily improve with an increase in the number of hidden layers and neuron nodes, and an excessive number might actually decrease the efficiency of the machine learning process. Full article

Tunnel–interchange connecting sections pose significant safety challenges on mountainous expressways due to their high incidence of accidents. Improving road safety necessitates a comprehensive understanding of driver behavior in such areas. This study explores the influences of road characteristics, signage information volume, and traffic conditions on drivers’ car-following and lane-changing behavior in tunnel–interchange diverging areas. Utilizing driving data from 25 subjects of 72 simulated road models, driving performance is assessed using the Friedman rank test and multivariate variance analysis. The results highlight the significant influence of both connection distance and signage information load on driving behavior. In tunnel–interchange scenarios, the reduction in velocity increased by 62.61%, and speed variability surged by 61.11%, indicating potential adverse effects on driving stability due to the environmental transitions. Decreased connection distances are associated with reduced lane-changing durations, larger steering angles, and increased failure rates. Furthermore, every two units of increase in signage information leads to a 13.16% rise in maximum deceleration and a 5% increase in time headway. Notably, the signage information volume shows a significant interaction with connection distance (F > 1.60, p < 0.045) for most car-following indicators. Hence, the study recommends a maximum connection distance of 700 m and signage information not exceeding nine units for optimal safety and stability. Full article

The incidence of gastric cancer (GC) is expected to increase to 1.77 million cases by 2040. To improve treatment outcomes, GC patients are increasingly treated with neoadjuvant chemotherapy (NAC) prior to curative-intent resection. Although NAC enhances locoregional control and comprehensive patient care, survival rates remain poor, and further investigations should establish outcomes assessment of current clinical pathways. Individually assessed parameters have served as benchmarks for treatment quality in the past decades. The Outcome4Medicine Consensus Conference underscores the inadequacy of isolated metrics, leading to increased recognition and adoption of composite measures. One of the most simple and comprehensive is the “All or None” method, which refers to an approach where a specific set of criteria must be fulfilled for an individual to achieve the overall measure. This narrative review aims to present the rationale for the implementation of a novel composite measure, Textbook Neoadjuvant Outcome (TNO). TNO integrates five objective and well-established components: Treatment Toxicity, Laboratory Tests, Imaging, Time to Surgery, and Nutrition. It represents a desired, multidisciplinary care and hospitalization of GC patients undergoing NAC to identify the treatment- and patient-related data required to establish high-quality oncological care further. A key strength of this narrative review is the clinical feasibility and research background supporting the implementation of the first and novel composite measure representing the “ideal” and holistic care among patients with locally advanced esophago-gastric junction (EGJ) and GC in the preoperative period after NAC. Further analysis will correlate clinical outcomes with the prognostic factors evaluated within the TNO framework. Full article

Li₂CO₃ is the most tenacious parasitic solid-state product in lithium–air batteries (LABs). Developing suitable redox mediators (RMs) is an efficient way to address the Li₂CO₃ issue, but only a few RMs have been investigated to date, and their mechanism of action also remains elusive. Herein, we investigate the effects of the central metal ion in binuclear metal phthalocyanines on the catalysis of Li₂CO₃ decomposition, namely binuclear cobalt phthalocyanine (bi-CoPc) and binuclear cobalt manganese phthalocyanine (bi-CoMnPc). Density functional theory (DFT) calculations indicate that the key intermediate peroxydicarbonate (*C₂O₆²⁻) is stabilized by bi-CoPc²⁺ and bi-CoMnPc³⁺, which is accountable for their excellent catalytic effects. With one central metal ion substituted by manganese for cobalt, the bi-CoMnPc’s second active redox couple shifts from the second Co(II)/Co(III) couple in the central metal ion to the Pc(-2)/Pc(-1) couple in the phthalocyanine ring. In artificial dry air (N₂-O₂, 78:22, v/v), the LAB cell with bi-CoMnPc in electrolyte exhibited 261 cycles under a fixed capacity of 500 mAh g⁻¹_carbon and current density of 100 mA g⁻¹_carbon, significantly better than the RM-free cell (62 cycles) and the cell with bi-CoPc (193 cycles). Full article

Information on long-term effects of postovulatory oocyte aging (POA) on offspring is limited. Whether POA affects offspring by causing oxidative stress (OS) and mitochondrial damage is unknown. Here, in vivo-aged (IVA) mouse oocytes were collected 9 h after ovulation, while in vitro-aged (ITA) oocytes were obtained by culturing freshly ovulated oocytes for 9 h in media with low, moderate, or high antioxidant potential. Oocytes were fertilized in vitro and blastocysts transferred to produce F1 offspring. F1 mice were mated with naturally bred mice to generate F2 offspring. Both IVA and the ITA groups in low antioxidant medium showed significantly increased anxiety-like behavior and impaired spatial and fear learning/memory and hippocampal expression of anxiolytic and learning/memory-beneficial genes in both male and female F1 offspring. Furthermore, the aging in both groups increased OS and impaired mitochondrial function in oocytes, blastocysts, and hippocampus of F1 offspring; however, it did not affect the behavior of F2 offspring. It is concluded that POA caused OS and damaged mitochondria in aged oocytes, leading to defects in anxiety-like behavior and learning/memory of F1 offspring. Thus, POA is a crucial factor that causes psychological problems in offspring, and antioxidant measures may be taken to ameliorate the detrimental effects of POA on offspring. Full article

The separation of rare earth ions (RE³⁺) from aqueous solutions poses a significant challenge due to their similar chemical and physical characteristics. This study presents a method for synthesizing hematite nanoparticles (Fe₂O₃ NPs) through the high-temperature phase transition of natural pyrite for adsorbing RE³⁺ from mine wastewater. The characteristics of Fe₂O₃ NPs were studied using XRD, SEM, BET, XPS, FTIR, and Zeta potential. The optimal condition for RE³⁺ adsorption by Fe₂O₃ NPs was determined to be at pH 6.0 with an adsorption time of 60 min. The maximum adsorption capacities of Fe₂O₃ NPs for La³⁺, Ce³⁺, Pr³⁺, Nd³⁺, Sm³⁺, Gd³⁺, Dy³⁺, and Y³⁺ were 12.80, 14.02, 14.67, 15.52, 17.66, 19.16, 19.94, and 11.82 mg·g⁻¹, respectively. The experimental data fitted well with the Langmuir isotherm and pseudo-second-order models, suggesting that the adsorption process was dominated by monolayer chemisorption. Thermodynamic analysis revealed the endothermic nature of the adsorption process. At room temperature, the adsorption of RE³⁺ in most cases (La³⁺, Ce³⁺, Pr³⁺, Nd³⁺, Sm³⁺, and Y³⁺) onto Fe₂O₃ NPs was non-spontaneous, except for the adsorption of Gd³⁺ and Dy³⁺, which was spontaneous. The higher separation selectivity of Fe₂O₃ NPs for Gd³⁺ and Dy³⁺ was confirmed by the separation factor. Moreover, Fe₂O₃ NPs exhibited excellent stability, with an RE³⁺ removal efficiency exceeding 94.70% after five adsorption–desorption cycles, demonstrating its potential for the recovery of RE³⁺ from mine wastewater. Full article

Background: Despite multimodality therapies, the prognosis of patients with malignant brain tumors remains extremely poor. One of the major obstacles that hinders development of effective therapies is the limited availability of clinically relevant and biologically accurate (CRBA) mouse models. Methods: We have developed a freehand surgical technique that allows for rapid and safe injection of fresh human brain tumor specimens directly into the matching locations (cerebrum, cerebellum, or brainstem) in the brains of SCID mice. Results: Using this technique, we successfully developed 188 PDOX models from 408 brain tumor patient samples (both high-and low-grade) with a success rate of 72.3% in high-grade glioma, 64.2% in medulloblastoma, 50% in ATRT, 33.8% in ependymoma, and 11.6% in low-grade gliomas. Detailed characterization confirmed their replication of the histopathological and genetic abnormalities of the original patient tumors. Conclusions: The protocol is easy to follow, without a sterotactic frame, in order to generate large cohorts of tumor-bearing mice to meet the needs of biological studies and preclinical drug testing. Full article

In this paper, we constructed a new and robust fixed point iterative scheme called the UO iterative scheme for the approximation of a contraction mapping. The scheme converges strongly to the fixed point of a contraction mapping. A rate of convergence result is shown with an example, and our scheme, when compared, converges faster than some existing iterative schemes in the literature. Furthermore, the stability and data dependence results are shown. Our new scheme is applied in the approximation of the solution to the oxygen diffusion model. Finally, our results are applied in the approximation of the solution to the boundary value problems using Green’s functions with an example. Full article

Alzheimer’s disease (AD) is characterized by amyloid beta (Aβ) buildup and neuronal degeneration. An association between low serum vitamin D levels and an increased risk of AD has been reported in several epidemiological studies. Calcitriol (1,25-dihydroxycholecalciferol) is the active form of vitamin D, and is generated in the kidney and many other tissues/organs, including the brain. It is a steroid hormone that regulates important functions like calcium/phosphorous levels, bone mineralization, and immunomodulation, indicating its broader systemic significance. In addition, calcitriol confers neuroprotection by mitigating oxidative stress and neuroinflammation, promoting the clearance of Aβ, myelin formation, neurogenesis, neurotransmission, and autophagy. The receptors to which calcitriol binds (vitamin D receptors; VDRs) to exert its effects are distributed over many organs and tissues, representing other significant roles of calcitriol beyond sustaining bone health. The biological effects of calcitriol are manifested through genomic (classical) and non-genomic actions through different pathways. The first is a slow genomic effect involving nuclear VDR directly affecting gene transcription. The association of AD with VDR gene polymorphisms relies on the changes in vitamin D consumption, which lowers VDR expression, protein stability, and binding affinity. It leads to the altered expression of genes involved in the neuroprotective effects of calcitriol. This review summarizes the neuroprotective mechanism of calcitriol and the role of VDR polymorphisms in AD, and might help develop potential therapeutic strategies and markers for AD in the future. Full article

Food systems are complex and multifaceted, comprising a diverse range of actors, processes, and interactions. Participatory system mapping can be employed to help understand this complexity and support the development of sustainable and resilient food systems. This article shares a participatory mapping approach that has been developed as part of the Climate–Biodiversity–Health (CBH) Nexus project in the Comox Valley, British Columbia, Canada. This research pursues two main aims: (1) to ground truth in the CBH system map of food systems, developed with the participation of stakeholders; and (2) to explain how participatory system mapping can be employed to clarify the complexity of food systems in a clear and concise manner for all stakeholders. This research contributes to the literature on participatory system mapping, including critiques of its practical utility, by employing participatory approaches to visualize multi-dimensional and multi-level system maps with an emphasis on verifying that they are clear, understandable/useful, and reliable for diverse stakeholder audiences. Full article

When cultivating on wheat bran or deactivated fungal mycelium as a model of “natural growth”, the ability of Trichoderma to synthesize extracellular L-lysine-α-oxidase (LysO) simultaneously with cell-wall-degrading enzymes (proteases, xylanase, glucanases, chitinases, etc.), responsible for mycoparasitism, was shown. LysO, in turn, causes the formation of H₂O₂ and pipecolic acid. These compounds are known to be signaling molecules and play an important role in the induction and development of systemic acquired resistance in plants. Antagonistic effects of LysO have been demonstrated against phytopathogenic fungi and Gram-positive or Gram-negative bacteria with dose-dependent cell death. The antimicrobial effect of LysO decreased in the presence of catalase. The generating intracellular ROS in the presence of LysO was also shown in both bacteria and fungi, which led to a decrease in viable cells. These results suggest that the antimicrobial activity of LysO is due to two factors: the formation of exogenous hydrogen peroxide as a product of the enzymatic oxidative deamination of L-lysine and the direct interaction of LysO with the cell wall of the micro-organisms. Thus, LysO on its own enhances the potential of the producer in the environment; namely, the enzyme complements the strategy of the fungus in biocontrol and indirectly participates in inducing SAR and regulating the relationship between pathogens and plants. Full article